Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

Binding of Hepatitis C Virus to CD81

1998 • 2,042 citations

Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent

1996 • 1,390 citations

The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice

1998 • 1,200 citations

Isolation of novel virus-like sequences associated with human hepatitis

1995 • 1,155 citations

Mutations in the Nonstructural Protein 5a Gene and Response to Interferon in Patients with Chronic Hepatitis C Virus 1b Infection

1996 • 1,016 citations

Internal ribosome entry site within hepatitis C virus RNA

1992 • 914 citations

Expression and identification of hepatitis C virus polyprotein cleavage products

1993 • 890 citations

Genetic Heterogeneity of Hepatitis C Virus: Quasispecies and Genotypes

1995 • 855 citations

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

1997 • 824 citations

Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA

1997 • 718 citations

Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections.

1992 • 712 citations

Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide

1996 • 707 citations

A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initation of hepatitis C and classical swine fever virus RNAs

1998 • 706 citations

Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus.

1996 • 694 citations

Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

1997 • 649 citations

Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups.

1990 • 640 citations

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.

1995 • 638 citations

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.

1991 • 636 citations

Hepatitis C virus core protein induces hepatic steatosis in transgenic mice.

1997 • 628 citations

Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

1998 • 613 citations

Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins

1991 • 611 citations

Nucleotide sequence and mutation rate of the H strain of hepatitis C virus.

1991 • 609 citations

Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

1996 • 607 citations

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

1998 • 603 citations

Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites

1993 • 601 citations

Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: Comparative study of four distinct genotypes

1992 • 578 citations

Identification of two flavivirus-like genomes in the GB hepatitis agent.

1995 • 561 citations

Sequence and genomic organization of GBV-C: A novel member of the flaviviridae associated with human non-A-E hepatitis

1996 • 531 citations

Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee

1997 • 525 citations

Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity

1997 • 518 citations

The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site

1996 • 504 citations

Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization.

1994 • 496 citations

Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions

1991 • 476 citations

Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus

1993 • 476 citations

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions

1993 • 464 citations

NS3 is a serine protease required for processing of hepatitis C virus polyprotein

1993 • 454 citations

Classification and nomenclature of viruses. Fifth report of the International Committee on Taxonomy of Viruses.

1991 • 453 citations

Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA

1996 • 450 citations

A Plan for Tanganyika

1964 • 445 citations

Structure of the hepatitis C virus RNA helicase domain

1997 • 444 citations

Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism

1993 • 435 citations

Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.

1991 • 426 citations

Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses

1994 • 423 citations

A second hepatitis C virus-encoded proteinase.

1993 • 416 citations

LONG-INCUBATION POST-TRANSFUSION HEPATITIS WITHOUT SEROLOGICAL EVIDENCE OF EXPOSURE TO HEPATITIS-B VIRUS

1974 • 414 citations

Biosynthesis and biochemical properties of the hepatitis C virus core protein

1994 • 413 citations

Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype

1996 • 412 citations

Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins

1994 • 411 citations

Sequence analysis of the 5' noncoding region of hepatitis C virus.

1992 • 410 citations

TRANSMISSIBLE AGENT IN NON-A, NON-B HEPATITIS

1978 • 408 citations

Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs

1992 • 402 citations

Hepatitis C Virus Core Protein Binds to the Cytoplasmic Domain of Tumor Necrosis Factor (TNF) Receptor 1 and Enhances TNF-Induced Apoptosis

1998 • 393 citations

Hepatitis C Virus Structural Proteins Assemble into Viruslike Particles in Insect Cells

1998 • 382 citations

Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus

1993 • 374 citations

CLINICAL AND SEROLOGICAL ANALYSIS OF TRANSFUSION-ASSOCIATED HEPATITIS

1975 • 359 citations

Association of hepatitis C virus in human sera with ?-lipoprotein

1992 • 358 citations

Hypervariable regions in the putative glycoprotein of hepatitis C virus

1991 • 353 citations

Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini

1994 • 347 citations

Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus.

1993 • 342 citations

Unique features of internal initiation of hepatitis C virus RNA translation.

1995 • 340 citations

Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells

1993 • 333 citations

Kinetic and structural analyses of hepatitis C virus polyprotein processing

1994 • 331 citations

Formation of native hepatitis C virus glycoprotein complexes

1997 • 322 citations

Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells

1995 • 311 citations

Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes

1993 • 310 citations

Association between NS3 and NS5 Proteins of Dengue Virus Type 2 in the Putative RNA Replicase Is Linked to Differential Phosphorylation of NS5

1995 • 306 citations

TRANSMISSION OF NON-A, NON-B HEPATITIS FROM MAN TO CHIMPANZEE

1978 • 305 citations

C-Terminal Domain of the Hepatitis C Virus NS3 Protein Contains an RNA Helicase Activity

1995 • 299 citations

Structure of the 3' terminus of the hepatitis C virus genome

1996 • 286 citations

A Novel Sequence Found at the 3′-Terminus of Hepatitis C Virus Genome

1995 • 283 citations

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A

1995 • 281 citations

Specific Interaction of Eukaryotic Translation Initiation Factor 3 with the 5′ Nontranslated Regions of Hepatitis C Virus and Classical Swine Fever Virus RNAs

1998 • 279 citations

Transcriptional Repression of p53 Promoter by Hepatitis C Virus Core Protein

1997 • 274 citations

The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)

1996 • 273 citations

Suppression of Apoptotic Cell Death by Hepatitis C Virus Core Protein

1996 • 268 citations

The La antigen binds 5′ noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation

1997 • 267 citations

Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein

1995 • 256 citations

Genomic organization of GB viruses A and B: two new members of the Flaviviridae associated with GB agent hepatitis

1995 • 256 citations

Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA.

1996 • 255 citations

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

1998 • 253 citations

Structural Requirements for Initiation of Translation by Internal Ribosome Entry within Genome-Length Hepatitis C Virus RNA

1996 • 253 citations

Sensitization to Fas-Mediated Apoptosis by Hepatitis C Virus Core Protein

1997 • 252 citations

A Retention Signal Necessary and Sufficient for Endoplasmic Reticulum Localization Maps to the Transmembrane Domain of Hepatitis C Virus Glycoprotein E2

1998 • 252 citations

The Native Form and Maturation Process of Hepatitis C Virus Core Protein

1998 • 251 citations

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing

1995 • 247 citations

RNA-dependent RNA Polymerase Activity of the Soluble Recombinant Hepatitis C Virus NS5B Protein Truncated at the C-terminal Region

1998 • 243 citations

BECLOMETHASONE AEROSOL IN CHRONIC BRONCHIAL ASTHMA

1974 • 235 citations

Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation

1995 • 234 citations

Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation

1995 • 233 citations

Inhibition of Tumor Necrosis Factor (TNF-α)-mediated Apoptosis by Hepatitis C Virus Core Protein

1998 • 232 citations

Density heterogeneities of hepatitis C virus in human sera due to the binding of ?-lipoproteins and immunoglobulins

1993 • 228 citations

ZINC DEFICIENCY IN MAN

1974 • 226 citations

A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro

1995 • 221 citations

Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses

1993 • 220 citations

Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor

1997 • 219 citations

Characterization of Cell Lines Allowing Tightly Regulated Expression of Hepatitis C Virus Core Protein

1996 • 218 citations

Production of Two Phosphoproteins from the NS5A Region of the Hepatitis C Viral Genome

1994 • 217 citations

Posttransfusion Non-A, Non-B Hepatitis: Physicochemical Properties of Two Distinct Agents

1983 • 211 citations

Hepatitis C virus glycoprotein folding: disulfide bond formation and association with calnexin

1996 • 208 citations

Transcripts of a Chimeric cDNA Clone of Hepatitis C Virus Genotype 1b Are Infectiousin Vivo

1998 • 208 citations

Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics

1994 • 206 citations

Crystal Structure of RNA Helicase from Genotype 1b Hepatitis C Virus

1998 • 202 citations

Pretreatment Virus Load and Multiple Amino Acid Substitutions in the Interferon Sensitivity-Determining Region Predict the Outcome of Interferon Treatment in Patients With Chronic Genotype 1B Hepatitis C Virus Infection

1997 • 199 citations

Interferon Resistance of Hepatitis C Virus Genotype 1b: Relationship to Nonstructural 5A Gene Quasispecies Mutations

1998 • 199 citations

The 3′-Untranslated Region of Hepatitis C Virus RNA Enhances Translation from an Internal Ribosomal Entry Site

1998 • 195 citations

Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa

1997 • 194 citations

Multiple Enzymatic Activities Associated with Recombinant NS3 Protein of Hepatitis C Virus

1998 • 194 citations

Secondary structure determination of the conserved 98-base sequence at the 3' terminus of hepatitis C virus genome RNA

1997 • 193 citations

A Hyperimmune Serum against a Synthetic Peptide Corresponding to the Hypervariable Region 1 of Hepatitis C Virus Can Prevent Viral Infection in Cell Cultures

1996 • 190 citations

The Taiwanese hepatitis C virus genome: Sequence determination and mapping the 5′ termini of viral genomic and antigenomic RNA

1992 • 189 citations

Pestivirus translation initiation occurs by internal ribosome entry

1995 • 189 citations

Characterization of truncated forms of hepatitis C virus glycoproteins.

1997 • 185 citations

The Hepatitis C Virus Encodes a Serine Protease Involved in Processing of the Putative Nonstructural Proteins from the Viral Polyprotein Precursor

1993 • 183 citations

Characterization of an Autonomous Subgenomic Pestivirus RNA Replicon

1998 • 179 citations

Studies on virus-specific nucleic acids synthesized in vertebrate and mosquito cells infected with flaviviruses

1978 • 177 citations

Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome

1997 • 177 citations

Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase

1997 • 177 citations

Determining the Size of Non-A, Non-B Hepatitis Virus by Filtration

1987 • 172 citations

Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-? therapy

1997 • 166 citations

Sequence analysis of the 5' nincoding region of hepatitis C virus

1992 • 165 citations

Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus.

1996 • 162 citations

An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A

1995 • 161 citations

Heterogeneous Nuclear Ribonucleoprotein L Interacts with the 3′ Border of the Internal Ribosomal Entry Site of Hepatitis C Virus

1998 • 160 citations

Almost the entire 5′ non‐translated region of hepatitis C virus is required for cap‐independent translation

1995 • 159 citations

Differential Subcellular Localization of Hepatitis C Virus Core Gene Products

1995 • 159 citations

Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation

1995 • 157 citations

Two hepatitis C virus glycoprotein E2 products with different C termini

1994 • 152 citations

Hepatitis C Virus Core Protein: Carboxy-Terminal Boundaries of Two Processed Species Suggest Cleavage by a Signal Peptide Peptidase

1996 • 151 citations

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

1997 • 150 citations

Inactivation of hepatitis B virus and non-A, non-B hepatitis by chloroform

1983 • 149 citations

Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor

1997 • 148 citations

Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity

1998 • 147 citations

Expression of processed core protein of hepatitis C virus in mammalian cells

1991 • 147 citations

Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted

1995 • 146 citations

Characterization of RNA Binding Activity and RNA Helicase Activity of the Hepatitis C Virus NS3 Protein

1996 • 146 citations

Homotypic Interaction and Multimerization of Hepatitis C Virus Core Protein

1996 • 145 citations

The NS5A/NS5 Proteins of Viruses from Three Genera of the Family Flaviviridae Are Phosphorylated by Associated Serine/Threonine Kinases

1998 • 145 citations

Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity.

1998 • 145 citations

Biochemical and Kinetic Analyses of NS5B RNA-Dependent RNA Polymerase of the Hepatitis C Virus

1998 • 143 citations

Characterization of hypervariable regions in the putative envelope protein of hepatitis C virus

1992 • 142 citations

The NS2 protein of hepatitis C virus is a transmembrane polypeptide

1995 • 142 citations

Predictors of Long-Term Response to High-Dose Interferon Therapy in Type II Cryoglobulinemia Associated With Hepatitis C Virus Infection

1997 • 142 citations

Complex Formation of NS5B with NS3 and NS4A Proteins of Hepatitis C Virus

1998 • 142 citations

A Steady-state and Pre-steady-state Kinetic Analysis of the NTPase Activity Associated with the Hepatitis C Virus NS3 Helicase Domain

1996 • 140 citations

Posttransfusion non-A, non-B hepatitis in chimpanzees. Physicochemical evidence that the tubule-forming agent is a small, enveloped virus.

1985 • 139 citations

Methylation status of intracellular dengue type 2 40 S RNA

1979 • 139 citations

Rapid sequence variation of the hypervariable region of hepatitis C virus during the course of chronic infection

1993 • 138 citations

Hepatitis C virus core and E2 protein expression in transgenic mice

1997 • 138 citations

Hepatitis C Virus Core from Two Different Genotypes Has an Oncogenic Potential but Is Not Sufficient for Transforming Primary Rat Embryo Fibroblasts in Cooperation with the H-rasOncogene

1998 • 136 citations

Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa

1997 • 136 citations

Evolution of Hepatitis C Virus Quasispecies in Hypervariable Region 1 and the Putative Interferon Sensitivity-Determining Region during Interferon Therapy and Natural Infection

1998 • 135 citations

Internal initiation of translation of hepatitis C virus RNA: the ribosome entry site is at the authentic initiation codon.

1996 • 135 citations

CYTO-TOXIC CHEMOTHERAPY IN BREAST-CANCER - REPLY

1985 • 134 citations

Complex Processing and Protein:Protein Interactions in the E2:NS2 Region of HCV

1994 • 133 citations

Transgenic expression of hepatitis C virus structural proteins in the mouse

1997 • 130 citations

Production of Nonstructural Proteins of Hepatitis C Virus Requires a Putative Viral Protease Encoded by NS3

1994 • 128 citations

Posttransfusion non-A, non-B hepatitis in chimpanzees

1985 • 127 citations

Genetic Organization and Diversity of the 3′ Noncoding Region of the Hepatitis C Virus Genome

1996 • 126 citations

Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing

1994 • 124 citations

Regulated processing of hepatitis C virus core protein is linked to subcellular localization

1997 • 124 citations

Mutations of hepatitis C virus 1b NS5A 2209–2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients

1997 • 124 citations

Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells

1992 • 124 citations

Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b

1997 • 119 citations

Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super‐families of helicases

1998 • 117 citations

Specific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X

1997 • 117 citations

Non-A, Non-B Hepatitis Transmission in Chimpanzees: A Project of the Transfusion-Transmitted Viruses Study Group

1978 • 115 citations

The N-terminal region of hepatitis C virus-encoded NS5A is important for NS4A-dependent phosphorylation

1997 • 115 citations

Processing of E1 and E2 Glycoproteins of Hepatitis C Virus Expressed in Mammalian and Insect Cells

1994 • 114 citations

Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase

1995 • 113 citations

Viral cysteine proteinases

1996 • 113 citations

Analysis of Hepatitis C Virus Capsid, E1, and E2/NS1 Proteins Expressed in Insect Cells

1993 • 113 citations

Expression, Isolation, and Characterization of the Hepatitis C Virus ATPase/RNA Helicase

1995 • 110 citations

The Prognostic Relevance of the Nonstructural 5A Gene Interferon Sensitivity Determining Region Is Different in Infections with Genotype 1b and 3a Isolates of Hepatitis C Virus

1998 • 108 citations

Hepatitis C Virus NS5B Protein Is a Membrane-Associated Phosphoprotein with a Predominantly Perinuclear Localization

1997 • 106 citations

Interaction between hepatitis C virus core protein and E1 envelope protein

1996 • 105 citations

The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins

1997 • 105 citations

Antibody to hepatitis C virus second envelope (HCV‐E2) glycoprotein: A new marker of HCV infection closely associated with viremia

1995 • 104 citations

Efficient Conditional Transgene Expression in Hepatitis C Virus cDNA Transgenic Mice Mediated by the Cre/loxP System

1998 • 104 citations

Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV

1995 • 103 citations

The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A

1995 • 100 citations

Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A

1996 • 99 citations

Expression of processed envelope protein of hepatitis C virus in mammalian and insect cells

1992 • 99 citations

Hepatitis C virus-encoded NS2-3 protease: cleavage-site mutagenesis and requirements for bimolecular cleavage

1995 • 98 citations

Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.

1994 • 94 citations

A Zinc Binding Site in Viral Serine Proteinases

1996 • 89 citations

Hepatitis C virus polyprotein processing: kinetics and mutagenic analysis of serine proteinase-dependent cleavage

1994 • 88 citations

Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system

1996 • 88 citations

Five New or Recently Discovered (GBV-A) Virus Species Are Indigenous to New World Monkeys and May Constitute a Separate Genus of theFlaviviridae

1997 • 87 citations

Analysis of hepatitis C virus core protein interaction domains.

1997 • 87 citations

Suppression of Actinomycin D-Induced Apoptosis by the NS3 Protein of Hepatitis C Virus

1996 • 85 citations

Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells

1997 • 84 citations

Complete 5′ Noncoding Region Is Necessary for the Efficient Internal Initiation of Hepatitis C Virus RNA

1994 • 81 citations

In vitro study of the NS2-3 protease of hepatitis C virus

1997 • 81 citations

Transfection of HepG2 cells with infectious hepatitis C virus genome.

1997 • 81 citations

Comparative Studies of the Core Gene Products of Two Different Hepatitis C Virus Isolates: Two Alternative Forms Determined by a Single Amino Acid Substitution

1994 • 79 citations

The Amino Terminal Deletion Mutants of Hepatitis C Virus Nonstructural Protein NS5A Function as Transcriptional Activators in Yeast

1997 • 77 citations

Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2

1994 • 74 citations

Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization

1997 • 74 citations

cis-acting RNA elements required for replication of bovine viral diarrhea virus–hepatitis C virus 5′ nontranslated region chimeras

1998 • 73 citations

Nuclear Localization Signals in the Core Protein of Hepatitis C Virus

1994 • 72 citations

Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase

1995 • 72 citations

DNA Helicase Activity of the Hepatitis C Virus Nonstructural Protein 3

1997 • 72 citations

The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme

1997 • 72 citations

Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-α catalytic subunit

1997 • 69 citations

TRANS-SUPPRESSION OF GENE EXPRESSION BY HEPATITIS C VIRAL CORE PROTEIN

1994 • 69 citations

The Influence of AUG Codons in the Hepatitis C Virus 5′ Nontranslated Region on Translation and Mapping of the Translation Initiation Window

1996 • 69 citations

Expression, Purification, and Partial Characterization of HCV RNA Polymerase

1997 • 68 citations

A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein

1997 • 63 citations

Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein

1998 • 62 citations

The sequence element of the internal ribosome entry site and a 25-kilodalton cellular protein contribute to efficient internal initiation of translation of hepatitis C virus RNA

1997 • 60 citations

Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable region 1

1994 • 60 citations

Molecular cloning and heterogeneity of the human hepatitis C virus (HCV) genome

1993 • 59 citations

Variability of the Hepatitis C Virus Genome

1998 • 54 citations

Non‐Structural Protein 3 of Hepatitis C Virus Inhibits Phosphorylation Mediated by cAMP‐Dependent Protein Kinase

1996 • 53 citations

Intracellular localization of full-length and truncated hepatitis C virus core protein expressed in mammalian cells

1994 • 53 citations

Virion-like structures in HeLa G cells transfected with the full-length sequence of the hepatitis C virus genome

1995 • 53 citations

Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli

1998 • 51 citations

Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase

1997 • 51 citations

Characterization of hepatitis C virus structural proteins with a recombinant baculovirus expression system

1993 • 50 citations

Two proteinase activities in HCV polypeptide expressed in insect cells using baculovirus vector

1993 • 47 citations

Delineation of Regions Important for Heteromeric Association of Hepatitis C Virus E1 and E2

1997 • 45 citations

Molecular structure of the Japanese hepatitis C viral genome

1991 • 45 citations

Expression and characterization of glycoprotein gp35 of hepatitis C virus using recombinant vaccinia virus

1992 • 43 citations

Cellular Proteins Specifically Bind to the 5′-Noncoding Region of Hepatitis C Virus RNA

1995 • 42 citations

Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein

1997 • 41 citations

Detection of Hepatitis C Virus Helicase Activity Using the Scintillation Proximity Assay System

1998 • 41 citations

Nucleotide sequence of hepatitis C virus (type 3b) isolated from a Japanese patient with chronic hepatitis C

1994 • 40 citations

Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains.

1997 • 39 citations

Identification of the domain required for trans-cleavage activity of hepatitis C viral serine proteinase

1994 • 38 citations

Hepatitis C virus core protein inhibits human immunodeficiency virus type 1 replication

1996 • 38 citations

Wild-Type, but Not Mutant-Type, p53 Enhances Nuclear Accumulation of the NS3 Protein of Hepatitis C Virus

1997 • 36 citations

Hepatitis C Virus Nonstructural Protein 5A Contains Potential Transcriptional Activator Domains

1997 • 35 citations

Variation in the hepatitis C virus NS5a region in relation to hypervariable region 1 heterogeneity during interferon treatment

1998 • 35 citations

Tightly Regulated Expression of the Entire Hepatitis C Virus Structural Region in Continuous Human Cell Lines

1998 • 34 citations

Substrate Specificity of the NS3 Serine Proteinase of Hepatitis C Virus as Determined by Mutagenesis at the NS3/NS4A Junction

1994 • 31 citations

Phosphorylation of tick-borne encephalitis virus NS5 protein

1997 • 31 citations

Secretion and purification of hepatitis C virus NS1 glycoprotein produced by recombinant baculovirus-infected insect cells

1993 • 30 citations

Detection of cellular proteins and viral core protein interacting with the 5′ untranslated region of hepatitis C virus RNA

1995 • 29 citations

Mutations in the nonstructural protein 5A gene and response to interferon therapy in young patients with chronic hepatitis C virus 1b infection

1997 • 28 citations

Purification and characterization of the NS3 serine protease domain of hepatitis C virus expressed in Saccharomyces cerevisiae.

1997 • 25 citations

Variability of Hepatitis C Virus Genome

2015 • 25 citations

Purification and in vitro-phospholabeling of secretory envelope proteins E1 and E2 of hepatitis C virus expressed in insect cells

1996 • 24 citations

Characterization of truncated forms of hepatitis C virus glycoproteins. J Gen Virol

1997 • 23 citations

Identification of novel sequences at the 5′ terminus of the hepatitis C virus genome

1998 • 14 citations

Antigenicity of hepatitis C virus envelope proteins expressed in Chinese hamster ovary cells

1996 • 13 citations

Localization of the different hepatitis C virus core gene products expressed in COS-1 cells.

1998 • 6 citations

Characterization of the Putative E2 Envelope Glycoprotein of Hepatitis C Virus Expressed in Stably Transformed Chinese Hamster Ovary Cells

1995 • 4 citations