Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

Hepatitis C Virus Infection

2001 • 2,979 citations

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

2001 • 1,183 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

CD8⁺T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection

2002 • 913 citations

Analysis of a Successful Immune Response against Hepatitis C Virus

1999 • 823 citations

Lack of Protective Immunity Against Reinfection with Hepatitis C Virus

1992 • 760 citations

Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

2000 • 747 citations

Recurrence of hepatitis C virus after loss of virus-specific CD4+ T-cell response in acute hepatitis C

1999 • 716 citations

Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection

1995 • 702 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection

2002 • 644 citations

Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease

2002 • 636 citations

Sustained Dysfunction of Antiviral CD8⁺T Lymphocytes after Infection with Hepatitis C Virus

2001 • 496 citations

No one is naive: the significance of heterologous T-cell immunity

2002 • 465 citations

Protection against persistence of hepatitis C

2002 • 439 citations

The Outcome of Hepatitis C Virus Infection Is Predicted by Escape Mutations in Epitopes Targeted by Cytotoxic T Lymphocytes

2001 • 415 citations

Activated Antigen-Specific CD8+ T Cells Persist in the Lungs Following Recovery from Respiratory Virus Infections

2001 • 403 citations

Association of Hepatitis C Virus–Specific CD8⁺T Cells with Viral Clearance in Acute Hepatitis C

2000 • 362 citations

Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.

1995 • 344 citations

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.

1997 • 333 citations

Interferon-γ inhibits replication of subgenomic and genomic hepatitis C virus RNAs

2002 • 315 citations

CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained

2000 • 313 citations

Protection from Respiratory Virus Infections Can Be Mediated by Antigen-Specific Cd4+ T Cells That Persist in the Lungs

2001 • 285 citations

Immunity in Hepatitis C Infection

1992 • 233 citations

Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection

2001 • 230 citations

Antiviral Effect and Virus-Host Interactions in Response to Alpha Interferon, Gamma Interferon, Poly(I)-Poly(C), Tumor Necrosis Factor Alpha, and Ribavirin in Hepatitis C Virus Subgenomic Replicons

2002 • 215 citations

Previously Infected and Recovered Chimpanzees Exhibit Rapid Responses That Control Hepatitis C Virus Replication upon Rechallenge

2002 • 181 citations

Virus-Specific CD8⁺Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and C

2002 • 174 citations

The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?

2002 • 126 citations

Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C.

1993 • 124 citations

Diagnosis of hepatitis C virus (HCV) infection using an immunodominant chimeric polyprotein to capture circulating antibodies: reevaluation of the role of HCV in liver disease.

1992 • 115 citations

Intrahepatic Genetic Inoculation of Hepatitis C Virus RNA Confers Cross-Protective Immunity

2001 • 95 citations

The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity

2002 • 93 citations

Mutations in Immunodominant T Cell Epitopes Derived from the Nonstructural 3 Protein of Hepatitis C Virus Have the Potential for Generating Escape Variants That May Have Important Consequences for T Cell Recognition

1999 • 91 citations

Use of recombinant HCV antigen in the serodiagnosis of hepatitis C virus infection: Significant improvement in HCV antibody detection as compared with the first generation HCV C100‐3 ELISA and the synthetic peptide EIA tests

1993 • 8 citations