Peginterferon alone or with ribavirin enhances HCV-specific CD4+ T-helper 1 responses in patients with chronic hepatitis C

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

2001 • 6,133 citations

Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C

1998 • 3,550 citations

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

1981 • 3,549 citations

Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus

1998 • 2,374 citations

Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

1998 • 2,112 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

Peginterferon Alfa-2a in Patients with Chronic Hepatitis C

2000 • 1,246 citations

Epidemiology of hepatitis C

1997 • 1,112 citations

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.

1993 • 945 citations

Peginterferon Alfa-2a in Patients with Chronic Hepatitis C and Cirrhosis

2000 • 893 citations

Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C

2000 • 885 citations

Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

2000 • 747 citations

Recurrence of hepatitis C virus after loss of virus-specific CD4+ T-cell response in acute hepatitis C

1999 • 716 citations

A Randomized, Double–Blind Trial Comparing Pegylated Interferon Alfa–2B to Interferon Alfa–2B As Initial Treatment for Chronic Hepatitis C

2001 • 683 citations

Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: Effects of dose and duration

1996 • 675 citations

Rational Design of a Potent, Long-Lasting Form of Interferon: A 40 kDa Branched Polyethylene Glycol-Conjugated Interferon α-2a for the Treatment of Hepatitis C

2001 • 605 citations

EPIDEMIOLOGY OF HEPATITIS

1965 • 438 citations

Quantitative analysis of hepatitis C virus-specific CD8⁺T cells in peripheral blood and liver using peptide-MHC tetramers

1999 • 421 citations

Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence

1999 • 419 citations

Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity

1997 • 413 citations

Efficacy and safety of pegylated (40-kd) interferon α-2a compared with interferon α-2a in noncirrhotic patients with chronic hepatitis C

2001 • 370 citations

Differential CD4+ and CD8+ T-cell responsiveness in hepatitis C virus infection

2001 • 345 citations

Hepatitis C virus–specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C

2000 • 318 citations

Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile

1999 • 315 citations

Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections

1997 • 306 citations

Racial differences in responses to therapy with interferon in chronic hepatitis C

1999 • 305 citations

The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses.

1998 • 288 citations

Viral kinetics in patients with chronic hepatitis C treated with standard or peginterferon α2a

2001 • 276 citations

Clinical Pharmacokinetics of Interferons

1990 • 245 citations

Cytokines in Viral Hepatitis

1999 • 217 citations

Liver-Derived CTL in Hepatitis C Virus Infection: Breadth and Specificity of Responses in a Cohort of Persons with Chronic Infection

1998 • 186 citations

Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: Correlation with clinical disease stages

2002 • 170 citations

Abnormal Priming of CD4⁺T Cells by Dendritic Cells Expressing Hepatitis C Virus Core and E1 Proteins

2002 • 164 citations

Relationship between biochemical, virological, and histological response during interferon treatment of chronic hepatitis C

1997 • 156 citations

Association of multispecific CD4+ response to hepatitis C and severity of recurrence after liver transplantation

1999 • 152 citations

Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection

1995 • 149 citations

Acute hepatitis C without and with schistosomiasis: Correlation with hepatitis C–Specific CD4+ T-cell and cytokine response

2001 • 141 citations

Prediction of response during interferon alfa 2b therapy in chronic hepatitis C patients using viral and biochemical characteristics: A comparison

1997 • 129 citations

Predictors of sustained response to alpha interferon therapy in chronic hepatitis C

1998 • 120 citations

Genetic complexity of the hypervariable region 1 (HVR1) of hepatitis C virus (HCV): Influence on the characteristics of the infection and responses to interferon alfa therapy in patients with chronic hepatitis C

1998 • 101 citations

The role of hepatitis C virus specific CD4+ T lymphocytes in acute and chronic hepatitis C

1996 • 100 citations

Number of interleukin‐4‐ and interferon‐γ‐secreting human T cells reactive with tetanus toxoid and the mycobacterial antigen PPD or phytohemagglutinin: distinct response profiles depending on the type of antigen used for activation

1993 • 97 citations

Factors Affecting Treatment Responses to Interferon- in Chronic Hepatitis C

1996 • 96 citations

Liver-Derived Hepatitis C Virus(HCV)-Specific CD4+ T Cells Recognize Multiple HCV Epitopes and Produce Interferon Gamma

2000 • 96 citations

Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C in naive patients: 1999 Update

2001 • 93 citations

Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C

1999 • 81 citations

The interferons: a biological system with therapeutic potential in viral infections

1994 • 79 citations

Viral, host and interferon-related factors modulating the effect of interferon therapy for hepatitis C virus infection

2001 • 76 citations

Detection of hepatitis C virus in paraffin-embedded liver biopsies of patients negative for viral RNA in serum

1999 • 73 citations

Mapping of immunodominant CD4+T lymphocyte epitopes of Hepatitis C virus antigens and their relevance during the course of chronic infection*1

1995 • 48 citations

Interferon‐α Treatment Induces Delayed CD4 Proliferative Responses to the Hepatitis C Virus Nonstructural Protein 3 Regardless of the Outcome of Therapy

1997 • 42 citations

[Treatment and prevention of hepatitis C].

2000 • 42 citations

The cellular immune responses induced in the follow-up of interferon-α treated patients with chronic hepatitis C may determine the therapy outcome

1998 • 41 citations

Indirect IL-4 Pathway in Type 1 Immunity

2002 • 38 citations

Triple immunofluorescence flow cytometry, using whole blood, of CD4+ and CD8+ lymphocytes expressing CD45RO and CD45RA

1993 • 33 citations

Quantitative analysis of specific Th1/Th2 helper cell responses and IgG subtype antibodies in interferon‐α‐treated patients with chronic hepatitis C

2001 • 25 citations

Immunological response to interferon‐γ priming prior to interferon‐α treatment in refractory chronic hepatitis C in relation to viral clearance

2001 • 18 citations