Molecular Basis for Differential Action of Vitamin D Analogs

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

1997 • 1,149 citations

Molecular Determinants for the Tissue Specificity of SERMs

2002 • 1,114 citations

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

1990 • 1,028 citations

Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.

1981 • 1,025 citations

The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand

2000 • 802 citations

Osteoclast-Like Cell Formation and its Regulation by Osteotropic Hormones in Mouse Bone Marrow Cultures*

1988 • 745 citations

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

1999 • 733 citations

Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects

2001 • 579 citations

Newly Identified Actions of the Vitamin D Endocrine System*

1992 • 563 citations

Identification of 1,25-Dihydroxycholecalciferol, a New Kidney Hormone controlling Calcium Metabolism

1971 • 496 citations

Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression.

1990 • 467 citations

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells.

1984 • 461 citations

Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3.

1983 • 424 citations

Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3.

1989 • 409 citations

A novel protein complex that interacts with the vitamin D₃ receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

1998 • 391 citations

Disorders of bone and mineral metabolism

1993 • 353 citations

Regulation of the metabolism of vitamin D.

1980 • 341 citations

20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses

1991 • 320 citations

Suppression of in vivo growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3.

1987 • 312 citations

Vitamin D, Calcium, and Epidermal Differentiation*

1993 • 287 citations

1,25-Dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow.

1985 • 280 citations

Identification of 1,25-Dihydroxycholecalciferol, a Form of Vitamin D ₃ Metabolically Active in the Intestine

1971 • 272 citations

Inhibition of human cancer cell growth by 1,25-dihydroxyvitamin D3 metabolites.

1983 • 264 citations

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

2001 • 223 citations

Effect of Calcium or 25OH Vitamin D3 Dietary Supplementation on Bone Loss at the Hip in Men and Women over the Age of 60*

2000 • 218 citations

1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D ₃ in the Intestine

1971 • 216 citations

Binding of Ligands and Activation of Transcription by Nuclear Receptors

2001 • 204 citations

Selective Interaction of Vitamin D Receptor with Transcriptional Coactivators by a Vitamin D Analog

1999 • 201 citations

Distinct Conformational Changes Induced by 20-epi Analogues of 1α,25-Dihydroxyvitamin D3 Are Associated with Enhanced Activation of the Vitamin D Receptor

1995 • 201 citations

Vitamin D3 receptor ablation sensitizes skin to chemically induced tumorigenesis

2002 • 195 citations

Two Vitamin D Response Elements Function in the Rat 1,25-Dihydroxyvitamin D 24-Hydroxylase Promoter

1995 • 190 citations

20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines.

1995 • 188 citations

Ligand Modulates the Conversion of DNA-Bound Vitamin D₃ Receptor (VDR) Homodimers into VDR-Retinoid X Receptor Heterodimers

1994 • 182 citations

Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage

2001 • 179 citations

Newly identified actions of the vitamin D endocrine system

1992 • 179 citations

Topical preparations for the treatment of psoriasis: a systematic review

2002 • 178 citations

Induction of Calcitonin Receptors by lα, 25- Dihydroxyvitamin D₃in Osteoclast-Like Multinucleated Cells Formed from Mouse Bone Marrow Cells*

1988 • 169 citations

Molecular Biology of the Vitamin D Hormone

1988 • 167 citations

A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer

1998 • 163 citations

Antiproliferative Effects of 1α,25-Dihydroxyvitamin D3 and Vitamin D Analogs on Tumor-Derived Endothelial Cells

2002 • 161 citations

Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486

2002 • 157 citations

Evidence for Ligand-Dependent Intramolecular Folding of the AF-2 Domain in Vitamin D Receptor-Activated Transcription and Coactivator Interaction

1997 • 154 citations

Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3.

1993 • 152 citations

Vitamin D₃ supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter

2003 • 144 citations

Impact of the Vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer

2002 • 140 citations

On the Mechanisms for the Selective Action of Vitamin D Analogs*

1991 • 139 citations

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

2000 • 139 citations

A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer

2002 • 138 citations

Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers.

1994 • 137 citations

Crystal Structure of a Mutant hERα Ligand-binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism

2001 • 131 citations

Paricalcitol in dialysis patients with calcitriol-resistant secondary hyperparathyroidism

2001 • 129 citations

ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis

2002 • 121 citations

Definition of the Molecular and Cellular Mechanisms Underlying the Tissue-selective Agonist/Antagonist Activities of Selective Estrogen Receptor Modulators

2002 • 120 citations

Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia

2001 • 116 citations

DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element.

1993 • 110 citations

Antagonistic Action of Novel 1α,25-Dihydroxyvitamin D3-26,23-lactone Analogs on Differentiation of Human Leukemia Cells (HL-60) Induced by 1α,25-Dihydroxyvitamin D3

1999 • 108 citations

Differential Interaction of α,25-Dihydroxyvitamin D3 Analogues and Their 20-epi Homologues with the Vitamin D Receptor

1997 • 103 citations

The mechanism for the disparate actions of calcitriol and 22-oxacalcitriol in the intestine.

1993 • 98 citations

20-Epi Analogues of 1,25-Dihydroxyvitamin D3 Are Highly Potent Inducers of DRIP Coactivator Complex Binding to the Vitamin D3 Receptor

1999 • 94 citations

1,25-Dihydroxyvitamin D3 Hypersensitivity of Osteoclast Precursors from Patients with Paget's Disease

2000 • 94 citations

Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism

1991 • 92 citations

Sensitive induction of apoptosis in breast cancer cells by a novel 1,25-dihydroxyvitamin D3 analogue shows relation to promoter selectivity

1997 • 90 citations

2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 Potently Stimulates Gene-specific DNA Binding of the Vitamin D Receptor in Osteoblasts

2003 • 90 citations

A highly conserved region in the hormone-binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid X receptor and for transcriptional activation.

1995 • 89 citations

Efficacy and safety of topical calcitriol (1,25-dihydroxyvitamin D³ ) for the treatment of psoriasis

1996 • 89 citations

1α,25(OH)2Vitamin D3-Regulated Expression of the Eukaryotic Genome

2009 • 89 citations

Structure-function studies of 1,25-dihydroxyvitamin D3 and the vitamin D endocrine system. 1,25-dihydroxy-pentadeuterio-previtamin D3 (as a 6-s-cis analog) stimulates nongenomic but not genomic biological responses

1993 • 89 citations

Comparative effects of calcipotriol (MC903) solution and placebo (vehicle of MC903) in the treatment of psoriasis of the scalp

1994 • 85 citations

Chemistry and conformation of vitamin D molecules

1995 • 84 citations

Increased biological activity of 20-EPI-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding

1994 • 74 citations

Different Molecular Mechanisms of Vitamin D₃ Receptor Antagonists

2001 • 74 citations

Vitamin D and the immune system

1987 • 74 citations

The vitamin D3 analog EB 1089 enhances the antiproliferative and apoptotic effects of adriamycin in MCF-7 breast tumor cells

2000 • 73 citations

Combined effect of vitamin D3 analogs and paclitaxel on the growth of MCF-7 breast cancer cells in vivo

1999 • 72 citations

Vitamin D3 analog, EB1089, inhibits growth of subcutaneous xenografts of the human colon cancer cell line, LoVo, in a nude mouse model

1997 • 71 citations

Antagonistic Action of a 25-Carboxylic Ester Analogue of 1α,25-Dihydroxyvitamin D3 Is Mediated by a Lack of Ligand-induced Vitamin D Receptor Interaction with Coactivators

2000 • 69 citations

Analysis of the Molecular Mechanism for the Antagonistic Action of a Novel 1α,25-Dihydroxyvitamin D3 Analogue toward Vitamin D Receptor Function

1999 • 68 citations

Conformationally Restricted Analogs of 1α,25-Dihydroxyvitamin D₃ and Its 20-Epimer: Compounds for Study of the Three-Dimensional Structure of Vitamin D Responsible for Binding to the Receptor

1996 • 65 citations

Conformation−Function Relationship of Vitamin D: Conformational Analysis Predicts Potential Side-Chain Structure

1998 • 62 citations

Highly potent transcriptional activation by 16-ene derivatives of 1,25-dihydroxyvitamin D3. Lack of modulation by 9-cis-retinoic acid of response to 1,25-dihydroxyvitamin D3 or its derivatives.

1994 • 61 citations

Defective binding and function of 1,25-dihydroxyvitamin D3 receptors in peripheral mononuclear cells of patients with end-organ resistance to 1,25-dihydroxyvitamin D.

1985 • 60 citations

Intestinal synthesis of 24-keto-1,25-dihydroxyvitamin D3. A metabolite formed in vivo with high affinity for the vitamin D cytosolic receptor.

1983 • 60 citations

Structure Activity Relationship of Carboxylic Ester Antagonists of the Vitamin D₃ Receptor

2000 • 59 citations

Vitamin D3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogs of 1,25-dihydroxyvitamin D3.

1995 • 57 citations

Critical role of helix 12 of the vitamin D 3 receptor for the partial agonism of carboxylic ester antagonists 1 1Edited by R. Huber

2002 • 57 citations

Vitamin D receptor‐dependent antitumour effects of 1,25‐dihydroxyvitamin D₃ and two synthetic analogues in three in vivo models of prostate cancer

2002 • 55 citations

Selective Recognition of Vitamin D Receptor Conformations Mediates Promoter Selectivity of Vitamin D Analogs

1999 • 55 citations

Differential Use of Transcription Activation Function 2 Domain of the Vitamin D Receptor by 1,25-Dihydroxyvitamin D3 and Its A Ring-Modified Analogs

1998 • 55 citations

A Rationale for Treatment of Hereditary Vitamin D-resistant Rickets with Analogs of 1α,25-Dihydroxyvitamin D3

2001 • 52 citations

Long-term treatment of postmenopausal osteoporosis with active vitamin D3, 1-alpha-hydroxycholecalciferol (1.ALPHA.-OHD3) and 1,24 dihydroxycholecalciferol (1,24(OH)2D3).

1985 • 52 citations

Comparative efficacy of calcipotriol (MC903) cream and betamethasone 17-valerate cream in the treatment of chronic plaque psoriasis. A randomized, double-blind, parallel group multicentre study

1997 • 49 citations

1,25(OH)2D3 modulation of mammary tumor cell growth in vitro and in vivo

1993 • 48 citations

Comparative efficacy of calcipotriol (MC903) cream and betamethasone 17-valerate cream in the treatment of chronic plaque psoriasis. A randomized, double-blind, parallel group multicentre study

1997 • 47 citations

Human vitamin D receptor-dependent transactivation in Saccharomyces cerevisiae requires retinoid X receptor.

1996 • 46 citations

Functional Characterization of a Novel Type of 1α,25-Dihydroxyvitamin D3Response Element Identified in the Mouse c-fosPromoter

1997 • 45 citations

Cellular and Molecular Events Associated with the Bone-Protecting Activity of the Noncalcemic Vitamin D Analog Ro-26-9228 in Osteopenic Rats

2002 • 41 citations

Novel nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium

2001 • 40 citations

Analysis of Vitamin D Analog-Induced Heterodimerization of Vitamin D Receptor with Retinoid X Receptor Using the Yeast Two-Hybrid System

1997 • 40 citations

Evidence for tissue‐ and cell‐type selective activation of the vitamin D receptor by Ro‐26‐9228, a noncalcemic analog of vitamin D₃

2003 • 40 citations

Clinical effects of maxacalcitol on secondary hyperparathyroidism of uremic patients

2001 • 40 citations

Retinoid X receptor isotype identity directs human vitamin D receptor heterodimer transactivation from the 24-hydroxylase vitamin D response elements in yeast.

1996 • 38 citations

Long Term 25-Hydroxyvitamin D₃Therapy in Postmenopausal Osteoporosis: Demonstration of Responsive and Nonresponsive Subgroups*

1983 • 38 citations

A 20-epi side chain restores growth-regulatory and transcriptional activities of an A ring-modified hybrid analog of 1α,25-dihydroxyvitamin D3 without increasing its affinity to the vitamin D receptor

1996 • 38 citations

Regulation of Ligand-Induced Heterodimerization and Coactivator Interaction by the Activation Function-2 Domain of the Vitamin D Receptor

2000 • 37 citations

The 16-ene vitamin D analogs.

1997 • 36 citations

1,25-Dihydroxyvitamin D3 and the Skin: A Unique Application for the Treatment of Psoriasis

1989 • 31 citations

The Role of Receptors in Biology and Medicine

1987 • 30 citations

Antagonistic Actionsin Vivoof (23S)-25-Dehydro-1α-Hydroxyvitamin D_3-26,23-Lactone on Calcium Metabolism Induced by 1α,25-Dihydroxyvitamin D₃

2001 • 30 citations

Selective Estrogen Receptor Modulators as a New Therapeutic Drug Group: Concept to Reality in a Decade

2002 • 30 citations

Enhanced biological activity of 1α,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1α,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity

1999 • 27 citations

Paricalcitol, a new agent for the management of secondary hyperparathyroidism in patients undergoing chronic renal dialysis

1999 • 27 citations

DIFFERENTIAL TIME COURSE OF INDUCTION OF 1α,25-DIHYDROXYVITAMIN D3-24-HYDROXYLASE mRNA EXPRESSION IN RATS BY 1α,25-DIHYDROXYVITAMIN D3 AND ITS ANALOGS

1997 • 27 citations

Metabolism of 1,25(OH)216-ene D3 in kidney: influence of structural modification of d-ring on side chain metabolism

1993 • 25 citations

"A highly conserved region in the hormone-binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid X receptor and for transcriptional activation".

1995 • 22 citations

Differential regulation of heterodimerization by 1α,25-dihydroxyvitamin D3 and its 20-epi analog

2001 • 20 citations

Potent vitamin D3 analogs: Their abilities to enhance transactivation and to bind to the vitamin D3 response element

1995 • 18 citations

From molecular biology to therapeutics

1994 • 18 citations

Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on mouse renal and intestinal 25-hydroxyvitamin D3-24-hydroxylase

1995 • 18 citations

Tissue specific metabolism of 1α,25‐dihydroxy‐20‐epi‐vitamin D₃ into new metabolites with significant biological activity: Studies in rat osteosarcoma cells (UMR 106 and ROS 17/2.8)

2001 • 17 citations

Studies on two new vitamin D analogs, EB 1089 and KH 1060: Effects on bone resorption and osteoclast recruitment in vitro

1995 • 17 citations

The Special Role of ``Hormonal'' Forms of Vitamin D in the Treatment of Osteoporosis

1999 • 17 citations

Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D3 Analogs

2003 • 16 citations

Characterization of the activation function-2 domain of the human 1,25-dihydroxyvitamin D3 receptor

1998 • 16 citations

A Central Dinucleotide within Vitamin D Response Elements Modulates DNA Binding and Transactivation by the Vitamin D Receptor in Cellular Response to Natural and Synthetic Ligands

2002 • 15 citations

Management of Secondary Hyperparathyroidism: The Gap between Diagnosis and Treatment

2000 • 11 citations

ChemInform Abstract: The 16‐Ene Vitamin D Analogues

1997 • 9 citations

Vitamin D Therapy in Patients Receiving Dialysis

1995 • 4 citations

[Drugs in development for the treatment of osteoporosis: Active vitamin D analog(ED-71)].

2002 • 1 citations