Molecular Determinants for the Tissue Specificity of SERMs

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

2000 • 1,658 citations

Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression

2000 • 1,414 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

1994 • 649 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen

1997 • 640 citations

The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT

1997 • 468 citations

Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1

1999 • 460 citations

Tissue microarrays for gene amplification surveys in many different tumor types.

1999 • 440 citations

Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer.

1994 • 390 citations

Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins

1998 • 366 citations

Mechanism of estrogen activation of c-myc oncogene expression.

1992 • 300 citations

Transcriptional Repression by Nuclear Hormone Receptors

2000 • 291 citations

HATs on and beyond chromatin

2001 • 174 citations

Selective Estrogen Receptor Modulation and Reduction in Risk of Breast Cancer, Osteoporosis, and Coronary Heart Disease

2001 • 172 citations

Isolation of Estrogen-Responsive Genes with a CpG Island Library

1998 • 135 citations

Characterization of the proximal estrogen-responsive element of human cathepsin D gene.

1994 • 127 citations

Making decisions through Myc

2001 • 121 citations

Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.

1992 • 116 citations

Nuclear receptor cofactors as chromatin remodelers

1999 • 104 citations

Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast

1992 • 103 citations

Molecular Cloning and Characterization of Mouse EBAG9, Homolog of a Human Cancer Associated Surface Antigen: Expression and Regulation by Estrogen

2001 • 54 citations

Fluorescence in Situ Hybridization Analysis of HER-2/neu, c-myc, and p53 in Endometrial Cancer

1999 • 32 citations