Evidence for tissue‐ and cell‐type selective activation of the vitamin D receptor by Ro‐26‐9228, a noncalcemic analog of vitamin D₃

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Molecular Determinants for the Tissue Specificity of SERMs

2002 • 1,114 citations

Development and characterization of a conditionally immortalized human fetal osteoblastic cell line

1995 • 485 citations

Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression.

1990 • 467 citations

Mechanisms of gene regulation by vitamin D3 receptor: a network of coactivator interactions

2000 • 321 citations

Structure-function relationships in the vitamin D endocrine system

1995 • 268 citations

Treatment of Established Postmenopausal Osteoporosis with Raloxifene: A Randomized Trial

1998 • 243 citations

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

2001 • 223 citations

A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer

1998 • 163 citations

Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486

2002 • 157 citations

A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer

2002 • 138 citations

Oophorectomy and Tamoxifen Adjuvant Therapy in Premenopausal Vietnamese and Chinese Women With Operable Breast Cancer

2002 • 131 citations

Transcriptional and post-transcriptional regulation of vitamin D-dependent calcium-binding protein gene expression in the rat duodenum by 1,25-dihydroxycholecalciferol.

1987 • 109 citations

Antagonistic Action of Novel 1α,25-Dihydroxyvitamin D3-26,23-lactone Analogs on Differentiation of Human Leukemia Cells (HL-60) Induced by 1α,25-Dihydroxyvitamin D3

1999 • 108 citations

Androgen receptor agonist activity of the synthetic progestin, medroxyprogesterone acetate, in human breast cancer cells

1999 • 108 citations

A novel synthetic vitamin D analogue, 2?-(3-hydroxypropoxy)1?, 25-dihydroxyvitamin D3 (ED-71), increases bone mass by stimulating the bone formation in normal and ovariectomized rats

1994 • 89 citations

Effect of 1,25(OH)2D3 on its receptor mRNA levels and osteocalcin synthesis in human osteosarcoma cells

1990 • 84 citations

Effect of 22-oxacalcitriol on bone histology of hemodialyzed patients with severe secondary hyperparathyroidism

2000 • 82 citations

Specific 1,25(OH)₂D₃-mediated regulation of transcellular calcium transport in Caco-2 cells

1999 • 80 citations

Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein

2001 • 77 citations

Analysis of the Molecular Mechanism for the Antagonistic Action of a Novel 1α,25-Dihydroxyvitamin D3 Analogue toward Vitamin D Receptor Function

1999 • 68 citations

Effects of 1,25-dihydroxyvitamin D3 and phorbol ester on 25-hydroxyvitamin D3 24-hydroxylase cytochrome P450 messenger ribonucleic acid levels in primary cultures of rat renal cells.

1993 • 68 citations

Calcipotriol Solution for the Treatment of Scalp Psoriasis: Evaluation of Efficacy, Safety and Acceptance in 3,396 Patients

2001 • 68 citations

The Novel Progesterone Receptor Antagonists RTI 3021–012 and RTI3021–022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins*

1999 • 66 citations

The effect of vitamin D on rat intestinal plasma membrane Ca-pump mRNA

1991 • 63 citations

A comparison of the effects of alfacalcidol treatment and vitamin D2 supplementation on calcium absorption in elderly women with vertebral fractures

1996 • 63 citations

19-nor-26,27-bishomo-vitamin D3 analogs: a unique class of potent inhibitors of proliferation of prostate, breast, and hematopoietic cancer cells.

1998 • 50 citations

Identification of Calbindin D-9k mRNA and Its Regulation by 1,25-Dihydroxyvitamin D3 in Caco-2 Cells

1994 • 46 citations

Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells

2001 • 42 citations

Cellular and Molecular Events Associated with the Bone-Protecting Activity of the Noncalcemic Vitamin D Analog Ro-26-9228 in Osteopenic Rats

2002 • 41 citations

Syntheses and preventive effects of analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats

1998 • 34 citations

Treatment with Active Vitamin D Metabolites and Concurrent Treatments in the Prevention of Hip Fractures: A Retrospective Study

1999 • 34 citations

Antagonistic Actionsin Vivoof (23S)-25-Dehydro-1α-Hydroxyvitamin D_3-26,23-Lactone on Calcium Metabolism Induced by 1α,25-Dihydroxyvitamin D₃

2001 • 30 citations

The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI 3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins

1999 • 29 citations

Photoaffinity labeling of the rat plasma vitamin D binding protein with [26,27-3H]-25-hydroxyvitamin D3-3.beta.-[N-(4-azido-2-nitrophenyl)glycinate]

1986 • 20 citations

Vitamin D, its metabolites and analogs: a review of the structural requirements for biological activity

1976 • 17 citations

Estrogen and Tamoxifen Interplay with T3 in Male Rats: Pharmacologically Distinct Classes of Estrogen Responses Affecting Growth, Bone, and Lipid Metabolism, and Their Relation to Serum GH and IGF-I

2001 • 13 citations

4-Hydroxytamoxifen binds to estrogen receptors and inhibits the growth of human endometrial cancer cells in vitro

1988 • 8 citations

Parathyroid hormone suppression by 22-oxacalcitriol in the severe parathyroid hyperplasia

1998 • 8 citations

Effects of the selective oestrogen receptor modulator—raloxifene—on calcium and PTH secretory dynamics in women with osteoporosis

2001 • 5 citations