Biology of Erythropoiesis, Erythroid Differentiation, and Maturation

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

2005 • 3,482 citations

A Gain-of-Function Mutation ofJAK2in Myeloproliferative Disorders

2005 • 3,402 citations

Osteoblastic cells regulate the haematopoietic stem cell niche

2003 • 3,370 citations

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

2005 • 3,358 citations

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

2010 • 3,169 citations

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

2005 • 2,958 citations

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches

2006 • 2,228 citations

Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

1996 • 2,160 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche

2004 • 1,929 citations

Frequent pathway mutations of splicing machinery in myelodysplasia

2011 • 1,906 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

2003 • 1,851 citations

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

2013 • 1,831 citations

Endothelial and perivascular cells maintain haematopoietic stem cells

2012 • 1,791 citations

The Human Hematopoietic Colony-Stimulating Factors

1987 • 1,728 citations

Balancing Acts

2004 • 1,663 citations

SomaticCALRMutations in Myeloproliferative Neoplasms with NonmutatedJAK2

2013 • 1,629 citations

Regulation of Phosphoinositide-Specific Phospholipase C

2001 • 1,604 citations

Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region

1996 • 1,548 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial

2003 • 1,243 citations

Cytokine receptor signalling

1995 • 1,242 citations

JAK2Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis

2007 • 1,232 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential

2005 • 1,169 citations

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

2011 • 1,148 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Regulatory Mechanisms in Stem Cell Biology

1997 • 1,060 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse Embryo*

1970 • 1,031 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

2006 • 994 citations

Identification of erythroferrone as an erythroid regulator of iron metabolism

2014 • 980 citations

Red cell membrane: past, present, and future

2008 • 960 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

The Kinetics of Cellular Proliferation

1960 • 948 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

Development of hematopoietic stem cell activity in the mouse embryo

1994 • 914 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A

2008 • 816 citations

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

2000 • 816 citations

Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic

2004 • 785 citations

The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia

1999 • 783 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.

1996 • 763 citations

Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

2007 • 760 citations

Multilineage gene expression precedes commitment in the hemopoietic system.

1997 • 757 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Nuclear reprogramming to a pluripotent state by three approaches

2010 • 751 citations

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

2002 • 751 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

The Biology and Clinical Uses of Blood Stem Cells

1997 • 729 citations

FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

1997 • 723 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts

2001 • 691 citations

CD34: structure, biology, and clinical utility [see comments]

1996 • 690 citations

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development

1997 • 683 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

A newly discovered class of human hematopoietic cells with SCID-repopulating activity

1998 • 640 citations

Molecular Cloning of Transferrin Receptor 2

1999 • 638 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development

1994 • 616 citations

The transcriptional control of hematopoiesis [see comments]

1996 • 608 citations

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

2011 • 603 citations

A common precursor for primitive erythropoiesis and definitive haematopoiesis

1997 • 601 citations

Krüppel-like Factors: Three Fingers in Many Pies

2001 • 600 citations

Transcriptional regulation of erythropoiesis: an affair involving multiple partners

2002 • 594 citations

Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å

1996 • 589 citations

The physiology of transferrin and transferrin receptors.

1987 • 586 citations

Erythropoietin receptor mRNA expression in human endothelial cells.

1994 • 584 citations

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

1995 • 582 citations

Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo

2002 • 581 citations

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

1995 • 572 citations

Regulation of Hemopoiesis by Bone Marrow Stromal Cells and Their Products

1990 • 546 citations

Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells

1997 • 539 citations

HFE gene knockout produces mouse model of hereditary hemochromatosis

1998 • 535 citations

Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity

1999 • 534 citations

Identification of a Hierarchy of Multipotent Hematopoietic Progenitors in Human Cord Blood

2007 • 532 citations

The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen.

1995 • 529 citations

Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells

2007 • 521 citations

Prospective isolation of human clonogenic common myeloid progenitors

2002 • 518 citations

Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1

2000 • 505 citations

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

2002 • 491 citations

Lineage-Specific Hematopoietic Growth Factors

2006 • 485 citations

Expression of Jak2V617F causes a polycythemia vera–like disease with associated myelofibrosis in a murine bone marrow transplant model

2006 • 484 citations

Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis

2009 • 481 citations

Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor

1990 • 468 citations

Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization

1988 • 464 citations

Aorta-associated CD34+ hematopoietic cells in the early human embryo

1996 • 461 citations

Erythroblastic islands: niches for erythropoiesis

2008 • 460 citations

The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone

2005 • 459 citations

Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin.

1993 • 455 citations

Biosynthesis of heme in mammals

2006 • 449 citations

Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference

2008 • 448 citations

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

1993 • 443 citations

Characterization of Definitive Lymphohematopoietic Stem Cells in the Day 9 Murine Yolk Sac

1997 • 438 citations

The relationship between blood groups and disease

2010 • 429 citations

Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment

2002 • 428 citations

Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells

1993 • 424 citations

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

2009 • 420 citations

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency

2011 • 412 citations

Reversible Expression of CD34 by Murine Hematopoietic Stem Cells

1999 • 408 citations

Sox17 Dependence Distinguishes the Transcriptional Regulation of Fetal from Adult Hematopoietic Stem Cells

2007 • 403 citations

From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

2011 • 403 citations

Reactivation of Developmentally Silenced Globin Genes by Forced Chromatin Looping

2014 • 402 citations

Nuclear lipid signalling

2003 • 399 citations

Thalassaemia

2011 • 390 citations

New mutations and pathogenesis of myeloproliferative neoplasms

2011 • 390 citations

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

1996 • 382 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

2003 • 378 citations

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

2010 • 375 citations

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

2010 • 369 citations

CXCR4 is required for the quiescence of primitive hematopoietic cells

2008 • 368 citations

Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus.

1995 • 367 citations

The human glucocorticoid receptor: One gene, multiple proteins and diverse responses

2005 • 366 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

A mouse model of juvenile hemochromatosis

2005 • 363 citations

Structure, function, and activation of the erythropoietin receptor

1993 • 360 citations

Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug

2013 • 359 citations

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo

2002 • 356 citations

Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

1996 • 348 citations

Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

1981 • 344 citations

The potential for isoenzyme‐selective modulation of protein kinase C

1997 • 343 citations

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

2010 • 342 citations

The molecular basis of blood diseases

1988 • 341 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

Host origin of marrow stromal cells following allogeneic bone marrow transplantation

1987 • 323 citations

Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression

2006 • 319 citations

Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia

2012 • 319 citations

Proof of principle for transfusion of in vitro–generated red blood cells

2011 • 312 citations

Regulation of the Erythropoietin Gene

1999 • 311 citations

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

2011 • 310 citations

Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

2005 • 310 citations

Interaction of the erythropoietin and stem-cell-factor receptors

1995 • 309 citations

The ultrastructure of the hemopoietic environment of the marrow: a review.

1981 • 308 citations

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults

2007 • 308 citations

The Emergence of Hematopoietic Stem Cells Is Initiated in the Placental Vasculature in the Absence of Circulation

2008 • 306 citations

Deletion of α4 Integrins from Adult Hematopoietic Cells Reveals Roles in Homeostasis, Regeneration, and Homing

2003 • 303 citations

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

1991 • 297 citations

The N-Terminal Domain of Janus Kinase 2 Is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor

2001 • 295 citations

Developmental stage–selective effect of somatically mutated leukemogenic transcription factor GATA1

2005 • 293 citations

Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition.

1986 • 293 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Biologic properties and enucleation of red blood cells from human embryonic stem cells

2008 • 292 citations

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

1995 • 291 citations

The glucocorticoid receptor is required for stress erythropoiesis

1999 • 291 citations

The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis

2006 • 290 citations

Discovering erythropoietin's extra-hematopoietic functions: Biology and clinical promise

2006 • 289 citations

A Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter

2006 • 286 citations

Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.

1989 • 285 citations

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

2010 • 285 citations

The multifunctional role of EKLF/KLF1 during erythropoiesis

2011 • 283 citations

Proliferation and maturation of human erythroid progenitors in liquid culture

1989 • 280 citations

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

1998 • 275 citations

Of macrophages and red blood cells; a complex love story

2014 • 274 citations

Ribosomal Protein S24 Gene Is Mutated in Diamond-Blackfan Anemia

2006 • 274 citations

The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation

2006 • 273 citations

Altered translation of GATA1 in Diamond-Blackfan anemia

2014 • 269 citations

Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1

2006 • 267 citations

An abundant erythroid protein that stabilizes free α-haemoglobin

2002 • 266 citations

Mouse embryonic hematopoiesis

1995 • 266 citations

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation

2010 • 261 citations

Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.

1990 • 259 citations

Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow

1996 • 258 citations

GATA Switches as Developmental Drivers

2010 • 256 citations

Hepcidin and Its Role in Regulating Systemic Iron Metabolism

2006 • 254 citations

Complete replacement of serum in primary cultures of erythropoietin-dependent red cell precursors (CFU-E) by albumin, transferrin, iron, unsaturated fatty acid, lecithin and cholesterol

1980 • 253 citations

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

2006 • 252 citations

THE ROLE OF ERYTHROPOIETIN IN REGULATION OF POPULATION SIZE AND CELL CYCLING OF EARLY AND LATE ERYTHROID PRECURSORS IN MOUSE BONE MARROW

1977 • 251 citations

New mutations inactivating transferrin receptor 2 in hemochromatosis type 3

2001 • 250 citations

Friend virus-induced erythroleukemia and the multistage nature of cancer

1991 • 249 citations

Erythropoietin receptor characteristics on primary human erythroid cells

1991 • 249 citations

Rapid reprogramming of globin gene expression in transient heterokaryons

1986 • 246 citations

Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.

1990 • 244 citations

Natural history of GATA1 mutations in Down syndrome

2003 • 244 citations

Yolk sac–derived primitive erythroblasts enucleate during mammalian embryogenesis

2004 • 243 citations

Human erythropoietin receptor: cloning, expression, and biologic characterization

1990 • 242 citations

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

2002 • 241 citations

Brain Capillary Endothelial Cells Express two forms of Erythropoietin Receptor mRNA

1996 • 241 citations

Purification of human blood burst‐forming units‐erythroid and demonstration of the evolution of erythropoietin receptors

1990 • 241 citations

Bone and the hematopoietic niche: a tale of two stem cells

2011 • 240 citations

The Glucocorticoid Receptor Cooperates With the Erythropoietin Receptor and c-Kit to Enhance and Sustain Proliferation of Erythroid Progenitors In Vitro

1999 • 240 citations

Dynamics of GATA transcription factor expression during erythroid differentiation

1993 • 238 citations

Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness

1989 • 236 citations

Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1mutation

2001 • 236 citations

Expression of cell-surface HLA-DR, HLA-ABC and glycophorin during erythroid differentiation

1981 • 234 citations

Hematopoietic defects in mice lacking the sialomucin CD34

1996 • 229 citations

Anti–VLA4/VCAM-1—Induced Mobilization Requires Cooperative Signaling Through the kit/mkit Ligand Pathway

1998 • 228 citations

A “knockdown” mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1

1997 • 228 citations

Hemoglobin F synthesis in vitro: evidence for control at the level of primitive erythroid stem cells.

1977 • 227 citations

Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin.

1987 • 225 citations

Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1low mice)

2002 • 224 citations

Antibodies to VLA4 Integrin Mobilize Long-Term Repopulating Cells and Augment Cytokine-Induced Mobilization in Primates and Mice

1997 • 224 citations

Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines.

1988 • 222 citations

A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia–reperfusion injury

2005 • 222 citations

Liver as the primary site of erythropoietin formation in the fetus.

1977 • 219 citations

Current mechanistic scenarios in hematopoietic stem/progenitor cell mobilization

2003 • 217 citations

Transcription factor networks in erythroid cell and megakaryocyte development

2011 • 215 citations

GATA-1 as a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1low Mouse Mutant

2003 • 214 citations

X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction

2002 • 213 citations

Stress erythropoiesis: new signals and new stress progenitor cells

2011 • 213 citations

Impaired ribosome biogenesis in Diamond-Blackfan anemia

2006 • 212 citations

Increased Glucocorticoid Receptor β Alters Steroid Response in Glucocorticoid-insensitive Asthma

2005 • 210 citations

Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.

1995 • 210 citations

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S ₁₂

2003 • 209 citations

Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome

2003 • 206 citations

Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality

2002 • 206 citations

Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.

1996 • 206 citations

Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

1996 • 204 citations

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

2011 • 204 citations

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

1993 • 203 citations

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia

2010 • 202 citations

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

2011 • 200 citations

Ruxolitinib: The First FDA Approved Therapy for the Treatment of Myelofibrosis

2012 • 200 citations

Regulation of transferrin receptor 2 protein levels by transferrin

2004 • 198 citations

X-linked thrombocytopenia caused by a novel mutation ofGATA-1

2001 • 195 citations

Renewal and commitment to differentiation of hemopoietic stem cells (an interpretive review)

1983 • 190 citations

An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis

2006 • 189 citations

Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway

2005 • 189 citations

Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits

2006 • 189 citations

Loops, Lineage, and Leukemia

1998 • 189 citations

Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors

2004 • 187 citations

A Dominant Mutation in the Gene Encoding the Erythroid Transcription Factor KLF1 Causes a Congenital Dyserythropoietic Anemia

2010 • 186 citations

The mechanism of action of erythropoietin

1986 • 185 citations

Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34+ hemopoietic progenitors

1996 • 184 citations

Sustained Activation of the Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway Is Required for Megakaryocytic Differentiation of K562 Cells

1997 • 184 citations

Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis

2011 • 183 citations

Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor.

1996 • 181 citations

Delay in the Fetal Globin Switch in Infants of Diabetic Mothers

1985 • 181 citations

Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation

2007 • 180 citations

Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia

2008 • 178 citations

The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny

2012 • 178 citations

Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation

2013 • 177 citations

Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts

2011 • 175 citations

Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway

1998 • 174 citations

Ontogeny of erythropoiesis

2008 • 174 citations

Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation

1997 • 174 citations

The embryonic origins of erythropoiesis in mammals

2012 • 172 citations

Extended Therapy with Intravenous Arginine Butyrate in Patients with β-Hemoglobinopathies

1995 • 171 citations

The Erythroid Phenotype of EKLF-Null Mice: Defects in Hemoglobin Metabolism and Membrane Stability

2005 • 171 citations

Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability

2005 • 170 citations

Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms

2010 • 170 citations

TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis

2000 • 170 citations

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

1996 • 170 citations

A Deletion Mutation in the SH2-N Domain of Shp-2 Severely Suppresses Hematopoietic Cell Development

1997 • 167 citations

A simple microassay for erythropoietin based on 3H-thymidine incorporation into spleen cells from phenylhydrazine treated mice.

1983 • 167 citations

Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS

2014 • 167 citations

GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis

2002 • 166 citations

Erythropoietin receptor. Subunit structure and activation.

1990 • 166 citations

Transferrin receptors and iron uptake during erythroid cell development

1982 • 164 citations

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders

2012 • 163 citations

The extracellular matrix of the hematopoietic microenvironment

1995 • 162 citations

Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression

2006 • 162 citations

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis

1997 • 162 citations

Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin

1995 • 161 citations

Adhesion of committed human hematopoietic progenitors to synthetic peptides from the C-terminal heparin-binding domain of fibronectin: cooperation between the integrin alpha 4 beta 1 and the CD44 adhesion receptor

1994 • 161 citations

JAK1 and Tyk2 Activation by the Homologous Polycythemia Vera JAK2 V617F Mutation

2005 • 161 citations

Very late activation antigen 4-vascular cell adhesion molecule 1 interaction is involved in the formation of erythroblastic islands.

1995 • 160 citations

Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development

2014 • 159 citations

Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria

2006 • 158 citations

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice

2010 • 157 citations

The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors

1997 • 157 citations

Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype

2008 • 156 citations

A Truncated Erythropoietin Receptor That Fails to Prevent Programmed Cell Death of Erythroid Cells

1992 • 156 citations

The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation

1997 • 155 citations

Loss of α-hemoglobin–stabilizing protein impairs erythropoiesis and exacerbates β-thalassemia

2004 • 155 citations

The C-Terminal Zinc Finger of GATA-1 or GATA-2 Is Sufficient To Induce Megakaryocytic Differentiation of an Early Myeloid Cell Line

1995 • 153 citations

Circulating erythropoietic precursors assessed in culture: characterization in normal men and patients with hemoglobinopathies

1977 • 153 citations

Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5

2002 • 153 citations

Blood cell cytoadhesion molecules.

1992 • 152 citations

Identification and characterization of hematopoietic stem cells from the yolk sac of the early mouse embryo.

1993 • 152 citations

Blast cell colony assay for umbilical cord blood and adult bone marrow progenitors

1987 • 152 citations

Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations

2005 • 151 citations

Potentiation of erythropoiesis in vitro by dexamethasone.

1976 • 151 citations

Global DNA Demethylation During Mouse Erythropoiesis in Vivo

2011 • 150 citations

Absence of Erythroblast Macrophage Protein (Emp) Leads to Failure of Erythroblast Nuclear Extrusion

2006 • 149 citations

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

1999 • 148 citations

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin

1992 • 147 citations

NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development

2009 • 147 citations

Characterization of a virus that causes transient aplastic crisis.

1984 • 146 citations

Erythroferrone contributes to recovery from anemia of inflammation

2014 • 146 citations

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages

2004 • 144 citations

KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia

2014 • 144 citations

Molecular Mechanism of AHSP-Mediated Stabilization of α-Hemoglobin

2004 • 142 citations

The second transferrin receptor regulates red blood cell production in mice

2014 • 141 citations

Synergistic Activation of MAP Kinase (ERK1/2) by Erythropoietin and Stem Cell Factor Is Essential for Expanded Erythropoiesis

1998 • 141 citations

BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors

2007 • 140 citations

Bipotential Primitive-Definitive Hematopoietic Progenitors in the Vertebrate Embryo

1997 • 140 citations

Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2)

2005 • 138 citations

Cell migrations in embryos

1984 • 137 citations

Mutations in the VHL gene in sporadic apparently congenital polycythemia

2003 • 137 citations

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

2010 • 136 citations

Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis

2012 • 135 citations

Placenta as a site for hematopoietic stem cell development

2005 • 135 citations

In Vitro Aspects of Erythropoiesis

1978 • 135 citations

Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene

1999 • 135 citations

In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis

2001 • 133 citations

Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin

2006 • 132 citations

HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

2014 • 132 citations

Autophagy Driven by a Master Regulator of Hematopoiesis

2011 • 131 citations

LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo

2013 • 131 citations

Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation

2006 • 131 citations

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

2014 • 130 citations

Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia

2011 • 129 citations

Quantitation of specific binding of erythropoietin to human erythroid colony‐forming cells

1988 • 129 citations

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

2011 • 127 citations

Two New EPO Receptor Mutations: Truncated EPO Receptors Are Most Frequently Associated With Primary Familial and Congenital Polycythemias

1997 • 127 citations

Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells

1997 • 127 citations

In Vitro Mass Production of Human Erythroid Cells from the Blood of Normal Donors and of Thalassemic Patients

2002 • 126 citations

Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia

1989 • 126 citations

MicroRNAs are shaping the hematopoietic landscape

2011 • 126 citations

The β Chain of the Interleukin-3 Receptor Functionally Associates With the Erythropoietin Receptor

1997 • 126 citations

From genes to structural morphogenesis: The genesis and epigenesis of a red blood cell

1987 • 124 citations

The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor

2007 • 124 citations

A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger

2008 • 123 citations

Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities

2006 • 122 citations

Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study

2014 • 121 citations

Quantitative Measurement of the Erythrocytic and Granulocytic Cells of the Marrow and Blood1

1958 • 121 citations

Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia

2004 • 119 citations

Discovery of Glucocorticoid Receptor-β in Mice with a Role in Metabolism

2010 • 119 citations

Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration

2011 • 119 citations

On the induction of fetal hemoglobin by butyrates: in vivo and in vitro studies with sodium butyrate and comparison of combination treatments with 5-AzaC and AraC

1989 • 118 citations

On the molecular origins of the chronic myeloproliferative disorders: it all makes sense

2005 • 117 citations

Fetal Hb Production during Acute Erythroid Expansion: I. OBSERVATIONS IN PATIENTS WITH TRANSIENT ERYTHROBLASTOPENIA AND POST‐PHLEBOTOMY

1980 • 116 citations

Expression and Function of Integrins on Hematopoietic Progenitor Cells

1997 • 116 citations

Tie2 activation contributes to hemangiogenic regeneration after myelosuppression

2005 • 115 citations

Matrix molecule interactions with hematopoietic stem cells.

1995 • 115 citations

Cell surface antigens on human marrow cells: Dissection of hematopoietic development using monoclonal antibodies and multiparameter flow cytometry

1987 • 115 citations

Expression of integrins in human bone marrow

1990 • 115 citations

Targeted Disruption of the Hepatic Transferrin Receptor 2 Gene in Mice Leads to Iron Overload

2006 • 114 citations

Differential homing and engraftment properties of hematopoietic progenitor cells from murine bone marrow, mobilized peripheral blood, and fetal liver

2001 • 110 citations

Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis

2005 • 110 citations

Differential binding of erythroid and myeloid progenitors to fibroblasts and fibronectin

1987 • 109 citations

In vitro differentiation of human granulocyte/macrophage and erythroid progenitors: comparative analysis of the influence of recombinant human erythropoietin, G-CSF, GM-CSF, and IL-3 in serum-supplemented and serum- deprived cultures

1988 • 109 citations

Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton

2006 • 108 citations

Long-term generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the presence of recombinant human stem cell factor

1992 • 108 citations

Hemopoietic stem cells in murine embryonic yolk sac and peripheral blood.

1989 • 107 citations

Negative regulation of erythroblast maturation by Fas-L+/TRAIL+ highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma

2002 • 105 citations

The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p

1990 • 104 citations

ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors

2013 • 104 citations

Eat‐me signals: Keys to molecular phagocyte biology and “Appetite” control

2011 • 103 citations

Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

2007 • 102 citations

Impaired megakaryopoiesis and behavioral defects inmafG-null mutant mice

1998 • 102 citations

Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with β thalassemia

2004 • 102 citations

Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy.

1996 • 101 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 101 citations

Absence of Glucocorticoid Receptor-β in Mice

1997 • 101 citations

Vesicle trafficking plays a novel role in erythroblast enucleation

2010 • 100 citations

New agents that stimulate erythropoiesis

2006 • 100 citations

Corticosteroid Receptor Genetic Polymorphisms and Stress Responsivity

2005 • 99 citations

X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation

2007 • 99 citations

Inhibition of an Erythroid Differentiation Switch by the Helix-Loop-Helix Protein Id1

1995 • 99 citations

The first trimester human placenta is a site for terminal maturation of primitive erythroid cells

2010 • 98 citations

Hematopoietic stem cell mobilization: updated conceptual renditions

2012 • 98 citations

Erythropoietin and Interleukin-3 Activate Tyrosine Phosphorylation of CBL and Association With CRK Adaptor Proteins

1997 • 97 citations

Loss of function mutations in RPL27 and RPS27 identified by whole‐exome sequencing in Diamond‐Blackfan anaemia

2014 • 97 citations

Distinct Domains of the GATA-1 Cofactor FOG-1 Differentially Influence Erythroid versus Megakaryocytic Maturation

2002 • 96 citations

Stem cell factor induces phosphatidylinositol 3′-kinase–dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells

2000 • 96 citations

Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts

2010 • 95 citations

The genomics of gene expression

2004 • 95 citations

Integrin expression profiles during erythroid differentiation

1992 • 95 citations

Mechanism of protein sorting during erythroblast enucleation: role of cytoskeletal connectivity

2003 • 95 citations

Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus

2010 • 94 citations

Rescue of GATA-1-Deficient Embryonic Stem Cells by Heterologous GATA-Binding Proteins

1995 • 94 citations

Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors

2010 • 94 citations

Glucocorticoid receptor alpha, beta and gamma expression vs in vitro glucocorticod resistance in childhood leukemia

2004 • 94 citations

A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia

2010 • 94 citations

An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray

2005 • 93 citations

Erythropoietin-independent erythrocyte production: signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34+ cells.

1996 • 93 citations

Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1

2006 • 93 citations

Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice

2000 • 91 citations

Von Hippel-Lindau–dependent polycythemia is endemic on the island of Ischia: identification of a novel cluster

2005 • 90 citations

The murine W/c-kit and Steel loci and the control of hematopoiesis.

1991 • 90 citations

Signaling Through the Interaction of Membrane-Restricted Stem Cell Factor and c-kit Receptor Tyrosine Kinase: Genetic Evidence for a Differential Role in Erythropoiesis

1998 • 90 citations

Glycophorin A dimerization and band 3 interaction during erythroid membrane biogenesis: in vivo studies in human glycophorin A transgenic mice

2001 • 89 citations

Direct effect of erythropoietin on rat vascular smooth-muscle cell via a putative erythropoietin receptor

1996 • 89 citations

Familial Erythrocytosis Associated With a Short Deletion in the Erythropoietin Receptor Gene

1997 • 88 citations

Negative regulation of early B lymphopoiesis by interleukin 3 and interleukin 1 alpha.

1994 • 88 citations

Control of haemoglobin switching by a developmental clock?

1985 • 88 citations

Consequences of exclusive expression in vivo of kit-ligand lacking the major proteolytic cleavage site

1998 • 87 citations

Molecular and cell biologic aspects of erythropoiesis in long-term bone marrow cultures

1981 • 86 citations

Establishment of Mouse Embryonic Stem Cell-Derived Erythroid Progenitor Cell Lines Able to Produce Functional Red Blood Cells

2008 • 86 citations

Loss of attachment to fibronectin with terminal human erythroid differentiation

1990 • 85 citations

Networking erythropoiesis

2010 • 85 citations

The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells

2011 • 85 citations

The production of myeloid blood cells and their regulation during health and disease

1988 • 85 citations

REGULATION OF ERYTHROPOIESIS. XX. KINETICS OF RED CELL PRODUCTION*

1968 • 85 citations

Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo

2006 • 85 citations

Erythropoiesis: normal and abnormal.

1967 • 85 citations

The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.

1996 • 84 citations

Erythropoietin-induced Recruitment of Shc via a Receptor Phosphotyrosine-independent, Jak2-associated Pathway

1995 • 84 citations

Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis

2011 • 84 citations

Cell adhesion in the stromal regulation of haemopoiesis

1992 • 84 citations

Erythropoietin alone induces erythroid burst formation by human embryonic but not adult BFU-E in unicellular serum-free culture [see comments]

1989 • 83 citations

Regulation of Hemoglobin Synthesis during the Development of the Red Cell

1977 • 83 citations

Erythropoietin receptor signals both proliferation and erythroid-specific differentiation.

1993 • 83 citations

Induction of human γ globin gene expression by histone deacetylase inhibitors

2003 • 83 citations

Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression

2014 • 83 citations

Transferrin receptor number, synthesis, and endocytosis during erythropoietin-induced maturation of Friend virus-infected erythroid cells.

1986 • 82 citations

Epigenetic regulation of fetal globin gene expression in adult erythroid cells

2014 • 81 citations

Cellular interactions

1988 • 81 citations

Leukemogenesis Caused by Incapacitated GATA-1 Function

2004 • 80 citations

The glucocorticoid receptor gene is in 5q–q32

1989 • 79 citations

Protein Kinase C α Controls Erythropoietin Receptor Signaling

2000 • 79 citations

Impaired Steel Factor Responsiveness Differentially Affects the Detection and Long-Term Maintenance of Fetal Liver Hematopoietic Stem Cells In Vivo

1997 • 79 citations

Defective Ribosomal Protein Gene Expression Alters Transcription, Translation, Apoptosis, and Oncogenic Pathways in Diamond‐Blackfan Anemia

2006 • 79 citations

Differential regulation of the human and murine CD34 genes in hematopoietic stem cells

2002 • 79 citations

GATA factor switching during erythroid differentiation

2010 • 78 citations

Erythroblastic islands: specialized microenvironmental niches for erythropoiesis

2006 • 78 citations

Loss of GATA‐1 full length as a cause of Diamond–Blackfan anemia phenotype

2014 • 78 citations

The helix-loop-helix protein Id inhibits differentiation of murine erythroleukemia cells.

1994 • 77 citations

Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin

2011 • 77 citations

Friend of GATA (FOG)-1 and FOG-2 Differentially Repress the GATA-Dependent Activity of Multiple Gonadal Promoters

2002 • 76 citations

Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity

2011 • 76 citations

Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis

2009 • 74 citations

Developmental Regulation of Human Globin Genes in Transgenic Mice

1985 • 74 citations

Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults

2011 • 74 citations

Relationship of Cell-Cycle Expression of Ia-like Antigenic Determinants on Normal and Leukemia Human Granulocyte-Macrophage Progenitor Cells to Regulation In Vitro by Acidic Isoferritins

1982 • 73 citations

The effect of reduced oxygen tension on colony formation of erythropoietic cells in vitro

1982 • 73 citations

Developmental changes in the function of hematopoietic stem cells.

1995 • 72 citations

Primitive erythropoiesis in the mammalian embryo

2010 • 72 citations

Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1low mice)

2001 • 71 citations

Enucleation of human erythroblasts involves non-muscle myosin IIB

2011 • 71 citations

Embryonic----Fetal Hb switch in humans: studies on erythroid bursts generated by embryonic progenitors from yolk sac and liver.

1984 • 70 citations

Early events in erythropoietin-induced signaling.

1996 • 70 citations

A critical role of VLA-4 in erythropoiesis in vivo

1996 • 70 citations

Abnormalities of GATA-1 in Megakaryocytes from Patients with Idiopathic Myelofibrosis

2005 • 70 citations

Isolation and characterization of human myeloid progenitor populations—TpoR as discriminator between common myeloid and megakaryocyte/erythroid progenitors

2006 • 69 citations

α‐Haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of β‐thalassaemia

2006 • 69 citations

Familial and congenital polycythemia in three unrelated families

1992 • 69 citations

Production of Embryonic and Fetal-Like Red Blood Cells from Human Induced Pluripotent Stem Cells

2011 • 68 citations

Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo

2011 • 68 citations

Ribosomal protein S19 expression during erythroid differentiation

2002 • 67 citations

The Potential of Stem Cells as an In Vitro Source of Red Blood Cells for Transfusion

2012 • 66 citations

Distinct roles of Mdm2 and Mdm4 in red cell production

2006 • 66 citations

Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia

2011 • 66 citations

On the in vivo action of erythropoietin: a quantitative analysis

1972 • 65 citations

Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD

2005 • 65 citations

Protein kinase C-α isoform is involved in erythropoietin-induced erythroid differentiation of CD34+ progenitor cells from human bone marrow

2000 • 65 citations

Primary familial polycythaemia associated with a novel point mutation in the erythropoietin receptor

1997 • 64 citations

Simultaneous Activation of Signals Through gp130, c-kit, and Interleukin-3 Receptor Promotes a Trilineage Blood Cell Production in the Absence of Terminally Acting Lineage-Specific Factors

1997 • 64 citations

Erythropoietin-induced cellular differentiation requires prolongation of the G1 phase of the cell cycle.

1995 • 64 citations

Developmental and Acquired Variations in Erythrocyte Carbonic Anhydrase Isozymes

1967 • 64 citations

Human embryonic hemopoiesis: Control mechanisms underlying progenitor differentiation in vitro

1988 • 63 citations

Knock-in Mutation of Transcription Factor GATA-3 into the GATA-1 Locus: Partial Rescue of GATA-1 Loss of Function in Erythroid Cells

1998 • 63 citations

Osteoprogenitors and the hematopoietic microenvironment

2011 • 63 citations

microRNAs: fine tuning of erythropoiesis

2012 • 62 citations

Dyserythropoietic Anemia and Thrombocytopenia due to a Novel Mutation in GATA-1

2005 • 62 citations

Phosphatidylinositol 3-Kinase/Akt Induced by Erythropoietin Renders the Erythroid Differentiation Factor GATA-1 Competent for TIMP-1 Gene Transactivation

2005 • 62 citations

FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis

2009 • 61 citations

Btk Is Required for an Efficient Response to Erythropoietin and for SCF-controlled Protection against TRAIL in Erythroid Progenitors

2004 • 60 citations

Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes

2011 • 60 citations

Alterations in Expression and Chromatin Configuration of the Alpha Hemoglobin-Stabilizing Protein Gene in Erythroid Krüppel-Like Factor-Deficient Mice

2006 • 59 citations

Erythroid cells in vitro: from developmental biology to blood transfusion products

2009 • 59 citations

Long noncoding RNAs in biology and hematopoiesis

2013 • 59 citations

New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis

2005 • 58 citations

Direct contact with stroma inhibits proliferation of human long-term culture initiating cells.

1996 • 58 citations

Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells

2005 • 58 citations

Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome

2011 • 58 citations

Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia.

1998 • 57 citations

Regulation of primary alloantibody response through antecedent exposure to a microbial T-cell epitope

2010 • 56 citations

Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond–blackfan anemia using inducible expression of siRNA against RPS19

2005 • 56 citations

Erythropoietin Receptor Mutations Associated With Familial Erythrocytosis Cause Hypersensitivity to Erythropoietin in the Heterozygous State

1999 • 56 citations

Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to αV integrins

2003 • 56 citations

Regional chromosomal assignment of the human glucocorticoid receptor gene to 5q31

1989 • 55 citations

Identification of a Critical Ligand Binding Determinant of the Human Erythropoietin Receptor

1996 • 55 citations

Analysis of the Ribosomal Protein S19 Interactome

2006 • 54 citations

Carbamylated Erythropoietin Reduces Radiosurgically-Induced Brain Injury

2006 • 54 citations

Monoclonal antibodies detecting antigenic determinants with restricted expression on erythroid cells: from the erythroid committed progenitor level to the mature erythroblast

1984 • 54 citations

Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR

2005 • 54 citations

Activation and Inhibition of Erythropoietin Receptor Function: Role of Receptor Dimerization

1994 • 53 citations

Erythro-megakaryocytic transcription factors associated with hereditary anemia

2014 • 53 citations

The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor

2006 • 53 citations

Erythropoietin Activates Raf1 by an Shc-Independent Pathway in CTLL-EPO-R Cells

1997 • 53 citations

Major erythrocyte membrane protein genes in EKLF-deficient mice

2006 • 52 citations

Unicellular-Unilineage Erythropoietic Cultures: Molecular Analysis of Regulatory Gene Expression at Sibling Cell Level

1999 • 52 citations

Erythroblastic islands, terminal erythroid differentiation and reticulocyte maturation

2011 • 52 citations

Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance

2008 • 51 citations

Context-dependent function of “GATA switch” sites in vivo

2011 • 51 citations

GATA Transcription Factors in Hematologic Disease

2005 • 51 citations

Hematopoiesis and angiogenesis.

2000 • 50 citations

Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants

2011 • 50 citations

Influence of Interleukin-3 and Other Growth Factors on α4β1 Integrin-Mediated Adhesion and Migration of Human Hematopoietic Progenitor Cells

1997 • 50 citations

Kit ligand in synergy with interleukin-3 amplifies the erythropoietin- independent, globin-synthesizing progeny of normal human burst-forming units-erythroid in suspension cultures: physiologic implications

1993 • 50 citations

Chrysin inhibited stem cell factor (SCF)/c-Kit complex-induced cell proliferation in human myeloid leukemia cells

2007 • 49 citations

Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice

2003 • 49 citations

Molecular Evolution of the Transferrin Receptor/Glutamate Carboxypeptidase II Family

2006 • 49 citations

Erythropoietin modulation of podocalyxin and a proposed erythroblast niche

2007 • 49 citations

Tsc-22 enhances TGF-? signaling by associating with Smad4 and induces erythroid cell differentiation

2005 • 49 citations

Protein Kinase C-ε Is Necessary for Erythropoietin's Up-regulation of c-myc and for Factor-dependent DNA Synthesis

1996 • 48 citations

Fetal hemoglobin in acute and chronic states of erythroid expansion

1993 • 48 citations

Mutation in the negative regulatory element of the erythropoietin receptor gene in a case of sporadic primary polycythemia.

1994 • 48 citations

Dexamethasone targeted directly to macrophages induces macrophage niches that promote erythroid expansion

2014 • 48 citations

Steroids and hematopoiesis. III. The response of granulocytic and erythroid colony-forming cells to steroids of different classes

1976 • 48 citations

Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins

2005 • 47 citations

Analysis of disease-causing GATA1 mutations in murine gene complementation systems

2013 • 47 citations

Transgenic rescue of GATA-1–deficient mice with GATA-1 lacking a FOG-1 association site phenocopies patients with X-linked thrombocytopenia

2003 • 47 citations

PKCϵ controls protection against TRAIL in erythroid progenitors

2005 • 46 citations

Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells

2011 • 46 citations

Delta-thalassemia due to a mutation in an erythroid-specific binding protein sequence 3' to the delta-globin gene

1992 • 46 citations

Erythropoietin and its mode of action.

1984 • 46 citations

Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis

2004 • 44 citations

Lineage-Restricted Expression of Protein Kinase C Isoforms in Hematopoiesis

1999 • 44 citations

Blood group antigens in health and disease

2005 • 44 citations

Combinatorial and distinct roles of α5 and α4 integrins in stress erythropoiesis in mice

2010 • 44 citations

Coexpression of embryonic, fetal, and adult globins in erythroid cells of human embryos: Relevance to the cell-lineage models of globin switching

1987 • 41 citations

Decreased expression of transcription factor GATA‐2 in haematopoietic stem cells in patients with aplastic anaemia

2001 • 41 citations

Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model

2010 • 41 citations

Glucocorticoid receptor transcriptional isoforms and resistance in multiple myeloma cells

2006 • 41 citations

The dominant negative β isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients

2011 • 41 citations

Klf1 Affects DNase II-Alpha Expression in the Central Macrophage of a Fetal Liver Erythroblastic Island: a Non-Cell-Autonomous Role in Definitive Erythropoiesis

2011 • 40 citations

Cell surface activation of the erythropoietin receptor by Friend spleen focus-forming virus gp55

1995 • 40 citations

Membrane assembly during erythropoiesis

2011 • 40 citations

Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19

1990 • 39 citations

Biochemical Fates of α Hemoglobin Bound to α Hemoglobin-stabilizing Protein AHSP

2006 • 39 citations

Critical band 3 multiprotein complex interactions establish early during human erythropoiesis

2011 • 39 citations

Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche

2014 • 38 citations

The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity

2004 • 38 citations

Elevated levels of transferrin receptor 2 mRNA, not transferrin receptor 1 mRNA, are associated with increased survival in acute myeloid leukaemia

2004 • 38 citations

Differential Expression of Protein Kinase C Isoform Transcripts in Human Hematopoietic Progenitors Undergoing Differentiation

1999 • 38 citations

Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation

2009 • 37 citations

Chromatin Architecture and Transcription Factor Binding Regulate Expression of Erythrocyte Membrane Protein Genes

2009 • 37 citations

Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia

2006 • 37 citations

A Novel EKLF Mutation in a Patient with Dyserythropoietic Anemia: The First Association of EKLF with Disease in Man.

2009 • 36 citations

A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation

2012 • 36 citations

The mechanism of expansion of late erythroid progenitors during erythroid regeneration: target cells and effects of erythropoietin and interleukin-3

1989 • 35 citations

A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis

2008 • 35 citations

Emergence of Human Angiohematopoietic Cells in Normal Development and from Cultured Embryonic Stem Cells

2007 • 35 citations

Closing the Iron Gate

2012 • 34 citations

MicroRNAs: Allies or Foes in erythropoiesis?

2011 • 34 citations

A new hematopoietic growth fator receptor superfamily: structural features and implications for signal transduction

1990 • 34 citations

During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool

2010 • 33 citations

Polycythemia as the first manifestation of Cushing’s disease

2006 • 33 citations

Characteristics of circulating erythroid colony‐forming cells in normal and polycythaemic man

1982 • 33 citations

Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds

2005 • 33 citations

Variation in the glucocorticoid receptor gene (NR3C1) may be associated with corticosteroid dependency and resistance in children with Crohn's disease

2011 • 32 citations

The cytoskeletal binding domain of band 3 is required for multiprotein complex formation and retention during erythropoiesis

2014 • 31 citations

SFL 23.6: a monoclonal antibody reactive with CFU-E, erythroblasts, and erythrocytes

1985 • 31 citations

Transcription Factor GATA-1 and Erythroid Development

1993 • 31 citations

Simultaneous assessment of i-antigenic expression and fetal hemoglobin in single red cells by immunofluorescence

1980 • 31 citations

Characterization of a novel form of transferrin receptor preferentially expressed on normal erythroid progenitors and precursors

1989 • 30 citations

DEVELOPMENTAL BIOLOGY OF HEMATOPOIESIS

1997 • 30 citations

Genome-Wide Analysis of Transcriptional Reprogramming in Mouse Models of Acute Myeloid Leukaemia

2011 • 30 citations

Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells

2014 • 29 citations

State of the Art Lecture: Erythropoietin receptor: application in drug development

1995 • 29 citations

Single-Cell STAT5 Signal Transduction Profiling in Normal and Leukemic Stem and Progenitor Cell Populations Reveals Highly Distinct Cytokine Responses

2009 • 29 citations

Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo

2006 • 28 citations

Differential Amplification of Murine Bipotent Megakaryocytic/Erythroid Progenitor and Precursor Cells During Recovery from Acute and Chronic Erythroid Stress

2005 • 28 citations

The role of fetal adrenal hormones in the switch from fetal to adult globin synthesis in the sheep

1985 • 28 citations

Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver

2015 • 28 citations

Activation of Developmentally Mutated Human Globin Genes by Cell Fusion

1988 • 28 citations

Thrombopoietin Enhances Proliferation and Differentiation of Murine Yolk Sac Erythroid Progenitors

1997 • 28 citations

Dynamic Expression of Specific miRNAs during Erythroid Differentiation of Human Embryonic Stem Cells

2012 • 27 citations

Chapter 15 Mitophagy in Mammalian Cells

2009 • 27 citations

The Expression of the Glucocorticoid Receptor in Human Erythroblasts is Uniquely Regulated by KIT Ligand: Implications for Stress Erythropoiesis

2012 • 27 citations

Expression of signal transduction proteins during the differentiation of primary human erythroblasts

2004 • 27 citations

Autosomal dominant hereditary hemochromatosis associated with two novel Ferroportin 1 mutations in Spain

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Pharmacological Induction of Fetal Hemoglobin Synthesis using Histone Deacetylase Inhibitors

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Marrow erythroid and neutrophil cellularity in the dog.

1975 • 26 citations

Targeting a new regulator of erythropoiesis to alleviate anemia

2014 • 25 citations

Enzyme-linked immunosorbent assay detects a potential soluble form of the erythropoietin receptor in human plasma

1996 • 25 citations

A structurally abnormal erythropoietin receptor gene in a human erythroleukemia cell line.

1992 • 25 citations

Differential use of protein 4.1 translation initiation sites during erythropoiesis: implications for a mutation-induced stage-specific deficiency of protein 4.1 during erythroid development

1996 • 25 citations

Cyclic hematopoiesis in dogs: studies of erythroid burst-forming cells confirm an early stem cell defect.

1988 • 25 citations

Interferon-γ mediates suppression of erythropoiesis but not reduced red cell survival following CpG-ODN administration in vivo

2006 • 25 citations

The erythropoietin receptor and the molecular basis of signal transduction.

1992 • 24 citations

Immunologie Study of the Age-related Loss of Activity of Six Enzymes in the Red Cells from Newborn Infants and Adults — Evidence for a Fetal Type of Erythrocyte Phosphofructokinase

1977 • 23 citations

A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia

2006 • 23 citations

Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells

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The extracytoplasmic domain of the erythropoietin receptor forms a monomeric complex with erythropoietin

1993 • 23 citations

The Erythroid Membrane Skeleton: Expression and Assembly During Erythropoiesis

1988 • 23 citations

Evidence for an accessory component that increases the affinity of the erythropoietin receptor.

1993 • 22 citations

Stage-specific functional roles of integrins in murine erythropoiesis

2014 • 22 citations

Microenvironmental Factors Involved in the Establishment of Erythropoiesis in Bone Marrow^a

1994 • 22 citations

Involvement of the Src kinase Lyn in phospholipase C-γ2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling

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X‐linked thrombocytopenia with thalassemia displays bone marrow reticulin fibrosis and enhanced angiogenesis: Comparisons with primary myelofibrosis

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Serum‐free culture of human hemopoietic progenitors in attenuated culture media

1988 • 20 citations

Lenalidomide for del(5q) and Non-del(5q) Myelodysplastic Syndromes

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LIN28A Expression Reduces Sickling of Cultured Human Erythrocytes

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The Abundance of Ferritin in Yolk‐Sac Derived Red Blood Cells of the Embryonic Mouse

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Erythropoietin-receptor expression and function during the initiation of murine yolk sac erythropoiesis.

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Mutagenesis Studies of the Human Erythropoietin Receptor

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Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation

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Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction

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Fetal to adult hemopoietic cell transplantation in humans: insights into hemoglobin switching

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Phenotypic Definition of the Progenitor Cells with Erythroid Differentiation Potential Present in Human Adult Blood

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The interaction of the erythropoietin receptor and gp55.

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Erythropoietin Down-Regulates Stem Cell Factor Receptor (Kit) Expression in the Leukemic Proerythroblast: Role of Lyn Kinase

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Alternatively spliced mRNAs encoding soluble isoforms of the erythropoietin receptor in murine cell lines and bone marrow

1994 • 16 citations

Hereditary haemolytic anaemias: unexpected sequelae of mutations in the genes for erythroid membrane skeletal proteins

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Reduced Gene Expression of Clustered Ribosomal Proteins in Diamond-Blackfan Anemia Patients Without RPS19 Gene Mutations

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Differential expression of alpha- and beta-globin genes in erythroleukemic cell lines.

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The origin of stromal cells in patients treated by bone marrow transplantation.

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Plasticity of Cells andEx VivoProduction of Red Blood Cells

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Isozyme patterns in erythrocytes from human fetuses

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The p67 laminin receptor identifies human erythroid progenitor and precursor cells and is functionally important for their bone marrow lodgment

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Alternative splicing of the erythropoietin receptor gene correlates with erythroid differentiation in rat hematopoietic and leukemic cells

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Mononuclear cells from a rare blood donor, after freezing under good manufacturing practice conditions, generate red blood cells that recapitulate the rare blood phenotype

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Banking on red blood cells

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Dynamic regulation of Gata1 expression during the maturation of conventional dendritic cells

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KIT associated intracellular tyrosines play an essential role in EpoR co-signaling

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Electrophoretic difference between fetal and adult acetylcholinesterase of human red cell membranes

1980 • 10 citations

Protein kinase Cα is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the ^Aγ globin‐promoter in cellular models of hemoglobin switching

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Fetal haemoglobin synthesis following fetal liver transplantation in man

1983 • 10 citations

Erythroid cells generated in the absence of specific 1-integrin heterodimers accumulate reactive oxygen species at homeostasis and are unable to mount effective antioxidant defenses

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GenetiC Mechanisms Underlying Regulation of Hemoglobin Mass

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Structure and regulation of the erythroid system at the level of progenitor cells

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Localization of an essential ligand binding determinant of the human erythropoietin receptor to a domain N-terminal to the WSXWS motif: implications for soluble receptor function.

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Membrane antigen expression during hemopoietic differentiation

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The fine structure of haemopoiesis in the human fetal liver. I. The haemopoietic precursor cells.

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Expression and In‐vitro Modulation of HLA Antigens in Ontogenic Development of Human Hemopoietic Systema

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Specific Domains of Fibronectin Mediate Adhesion and Migration of Early Murine Erythroid Progenitors

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Biogenesis of erythrocyte membrane skeleton in health and disease

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Lack of relationship between soluble erythropoietin receptor levels and erythroid parameters in anemic patients [letter; comment]

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Role of alternative splicing of the rat erythropoietin receptor gene in normal and erythroleukemia cells.

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Ligand Binding Kinetics of a Soluble Full Length Murine Erythropoietin Receptor

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Haemopoietic Regulation and the Role of the Macrophage in Erythropoietic Gene Expression

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Kit-Ligand—Stem Cell Factor

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Bloody regulators

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The use of recombinant human erythropoietin [rHuEpo] in man.

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18 Circulation Plays an Essential Role in Distributing Hematopoietic Progenitors from the Yolk Sac to the Embryo Proper; Lessons from the Ncx1-Null Mouse.

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