The Erythroid Phenotype of EKLF-Null Mice: Defects in Hemoglobin Metabolism and Membrane Stability

A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†

1993 • 703 citations

Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

1995 • 620 citations

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

1999 • 607 citations

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

1995 • 572 citations

The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon

2002 • 567 citations

A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins.

1993 • 464 citations

Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation

2005 • 427 citations

Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice

2003 • 400 citations

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

2001 • 373 citations

The active spatial organization of the β-globin locus requires the transcription factor EKLF

2004 • 357 citations

Regulation of protein synthesis by heme-regulated eIF-2α kinase

1995 • 297 citations

An abundant erythroid protein that stabilizes free α-haemoglobin

2002 • 266 citations

Thalassemia: The consequences of unbalanced hemoglobin synthesis

1966 • 256 citations

The molecular basis of blood diseases

2000 • 228 citations

Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by ts mutants of avian erythroblastosis virus

1982 • 220 citations

Analyses of beta-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor.

1994 • 194 citations

FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1

2004 • 182 citations

Mechanisms of developmental control of transcription in the murine α- and β-globin loci

1999 • 144 citations

Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis

2001 • 121 citations

Establishment of normal, terminally differentiating mouse erythroid progenitors: molecular characterization by cDNA arrays

2001 • 112 citations

Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny

1996 • 110 citations

Cooperative signaling between cytokine receptors and the glucocorticoid receptor in the expansion of erythroid progenitors: molecular analysis by expression profiling

2003 • 105 citations

Erythroleukemia differentiation. Distinctive responses of the erythroid-specific and the nonspecific delta-aminolevulinate synthase mRNA.

1991 • 89 citations

Regulation of erythroid 5-aminolevulinate synthase expression during erythropoiesis

1999 • 88 citations

Erythroid Kruppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta -globin locus control region

1998 • 77 citations

Stage-Specific Repression by the EKLF Transcriptional Activator

2004 • 76 citations

Headpiece domain of dematin is required for the stability of the erythrocyte membrane

2002 • 71 citations

Thalassemia intermedia: moderate reduction of beta globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element

1991 • 63 citations

Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages

2004 • 57 citations

Fetal expression of a human Aγ globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos

2000 • 55 citations

Thalassemia intermedia: moderate reduction of beta globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element

1991 • 54 citations

A Shortened Life Span of EKLF−/− Adult Erythrocytes, Due to a Deficiency of β-Globin Chains, Is Ameliorated by Human γ-Globin Chains

1997 • 44 citations

Erythroid regulatory elements

1993 • 37 citations

Thalassemias

2001 • 31 citations

Inhibition of heme synthesis induces apoptosis in human erythroid progenitor cells

1995 • 29 citations

Characterization of hypersensitive sites, protein-binding motifs, and regulatory elements in both promoters of the mouse porphobilinogen deaminase gene

1991 • 29 citations

Transcription Factor Erythroid Krüppel-like Factor (ELKF) Is Essential for the Erythropoietin-induced Hemoglobin Production but Not for Proliferation, Viability, or Morphological Maturation

1998 • 25 citations

beta-Thalassemia mutation at -90C-->T impairs the interaction of the proximal CACCC box with both erythroid and nonerythroid factors [letter]

1996 • 22 citations

Erythroid 5-Aminolevulinate Synthase Is Required for Erythroid Differentiation in Mouse Embryonic Stem Cells

1998 • 15 citations

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