Pharmacological Induction of Fetal Hemoglobin Synthesis using Histone Deacetylase Inhibitors

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Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death

1994 • 3,225 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

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Histone acetylation in chromatin structure and transcription

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Chromatin Structure: A Repeating Unit of Histones and DNA

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Histone acetylation and transcriptional regulatory mechanisms

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Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome

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A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

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Pain in Sickle Cell Disease

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Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins

2000 • 1,360 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells

2000 • 1,158 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

A direct link between core histone acetylation and transcriptionally active chromatin.

1988 • 905 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Effects of sodium butyrate, a new pharmacological agent, on cells in culture

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Characterization of Five Human cDNAs with Homology to the Yeast SIR2 Gene: Sir2-like Proteins (Sirtuins) Metabolize NAD and May Have Protein ADP-Ribosyltransferase Activity

1999 • 781 citations

Three proteins define a class of human histone deacetylases related to yeast Hda1p

1999 • 744 citations

Sir2 links chromatin silencing, metabolism, and aging

2000 • 725 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†

1993 • 703 citations

Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells

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Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

1995 • 620 citations

The Human Histone Deacetylase Family

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HDAC4 deacetylase associates with and represses the MEF2 transcription factor

1999 • 539 citations

Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.

1984 • 514 citations

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

1982 • 496 citations

Transcription complex stability and chromatin dynamics in vivo

1995 • 488 citations

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

1997 • 480 citations

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

1996 • 469 citations

A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins.

1993 • 464 citations

RNA synthesis and histone acetylation during the course of gene activation in lymphocytes.

1966 • 445 citations

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

1993 • 443 citations

GATA transcription factors: key regulators of hematopoiesis.

1995 • 430 citations

5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons.

1982 • 396 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

Fetal Hemoglobin in Sickle Cell Anemia: Determinants of Response to Hydroxyurea

1997 • 388 citations

Hydroxyurea and Sickle Cell Anemia Clinical Utility of a Myelosuppressive “Switching” Agent

1996 • 327 citations

Modulation of Chromatin Folding by Histone Acetylation

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Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor

2000 • 296 citations

Natural History of Sickle Cell Anemia in Saudi Arabs

1978 • 287 citations

HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor

1999 • 280 citations

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

1983 • 270 citations

Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial

1995 • 257 citations

Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes.

1993 • 234 citations

β-globin Gene Switching and DNase I Sensitivity of the Endogenous β-globin Locus in Mice Do Not Require the Locus Control Region

2000 • 229 citations

Augmentation of Fetal-Hemoglobin Production in Anemic Monkeys by Hydroxyurea

1984 • 227 citations

A New Family of Human Histone Deacetylases Related toSaccharomyces cerevisiae HDA1p

1999 • 227 citations

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1977 • 227 citations

Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate

1994 • 213 citations

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1997 • 194 citations

Molecular basis for dominantly inherited inclusion body beta-thalassemia.

1990 • 191 citations

Delay in the Fetal Globin Switch in Infants of Diabetic Mothers

1985 • 181 citations

THE SIGNIFICANCE OF THE PAUCITY OF SICKLE CELLS IN NEWBORN NEGRO INFANTS

1948 • 181 citations

Cloning and characterization of a novel human histone deacetylase, HDAC8

2000 • 178 citations

Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate

1994 • 178 citations

Stimulation of F-Cell Production in Patients with Sickle-Cell Anemia Treated with Cytarabine or Hydroxyurea

1985 • 160 citations

Effect of hydroxyurea on the rheological properties of sickle erythrocytes in vivo

1989 • 158 citations

Stimulation of Fetal Hemoglobin Synthesis by Erythropoietin in Baboons

1987 • 150 citations

DNA associated with hyperacetylated histone is preferentially digested by DNase I

1978 • 147 citations

Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate.

1984 • 146 citations

Fetal hemoglobin levels in adults

1994 • 144 citations

Chromatin Remodeling and Transcriptional Regulation

1999 • 143 citations

Cloning and characterization of human histone deacetylase 8

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Induction of γ-Globin by Histone Deacetylase Inhibitors

1997 • 139 citations

Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts.

1983 • 136 citations

Nucleosome Structural Changes Due to Acetylation

1994 • 133 citations

Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching.

1988 • 132 citations

Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2

1999 • 130 citations

Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia

1989 • 126 citations

Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1.

1994 • 123 citations

Arabinosylcytosine Induces Fetal Hemoglobin in Baboons by Perturbing Erythroid Cell Differentiation Kinetics

1984 • 123 citations

On the induction of fetal hemoglobin by butyrates: in vivo and in vitro studies with sodium butyrate and comparison of combination treatments with 5-AzaC and AraC

1989 • 118 citations

Differential Expression of Human Histone Deacetylase mRNAs in Response to Immune Cell Apoptosis Induction by Trichostatin A and Butyrate

1998 • 99 citations

Hydroxyurea affects cell morphology, cation transport, and red blood cell adhesion in cultured vascular endothelial cells

1994 • 98 citations

FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes

2000 • 84 citations

Induction of human γ globin gene expression by histone deacetylase inhibitors

2003 • 83 citations

Relative Rates of Fetal Hemoglobin and Adult Hemoglobin Synthesis in Cord Blood of Infants of Insulin-Dependent Diabetic Mothers

1985 • 82 citations

Perturbations in the erythroid marrow progenitor cell pools may play a role in the augmentation of HbF by 5-azacytidine

1984 • 82 citations

Therapeutic Approaches to Hemoglobin Switching in Treatment of Hemoglobinopathies

1992 • 81 citations

Human Hemoglobin Switching

1991 • 76 citations

Stimulation of fetal hemoglobin production by short chain fatty acids

1995 • 76 citations

Hb F Production in Stressed Erythropoiesis: Observations and Kinetic Modelsa^a

1985 • 74 citations

3 Sickle cell disease pathophysiology

1993 • 73 citations

F reticulocyte response in sickle cell anemia treated with recombinant human erythropoietin: a double-blind study

1993 • 72 citations

alpha-Amino-N-butyric acid stimulates fetal hemoglobin in the adult

1988 • 70 citations

Reactivation of fetal hemoglobin in patients with beta-thalassemia.

1996 • 70 citations

F reticulocyte response in sickle cell anemia treated with recombinant human erythropoietin: a double-blind study

1993 • 69 citations

Pharmacological induction of fetal hemoglobin in sickle cell disease and β-thalassemia

2001 • 64 citations

Globin-chain specificity of oxidation-induced changes in red blood cell membrane properties

1992 • 63 citations

5-Azacytidine increases HbF production and reduces anemia in sickle cell disease: dose-response analysis of subcutaneous and oral dosage regimens

1985 • 62 citations

DNA methylation: a secondary event in globin gene switching?

1988 • 62 citations

The regulation of human globin gene switching

1993 • 62 citations

Analysis of the erythroid phenotype of HEL cells: clonal variation and the effect of inducers

1987 • 61 citations

The β-and -Thalassemia Repository (Ninth Edition; Part I)

1998 • 60 citations

Butyrate in the treatment of sickle cell disease and β-thalassemia

1995 • 60 citations

Reversible effects of Na-butyrate on histone acetylation

1978 • 59 citations

FLUPHENAZINE DECANOATE

1976 • 57 citations

Metabolic persistence of fetal hemoglobin

1995 • 56 citations

Structural modifications of histones and their possible role in the regulation of ribonucleic acid synthesis.

1966 • 55 citations

Overview of pathophysiology and rationale for treatment of sickle cell anemia.

1997 • 55 citations

Perturbations in the erythroid marrow progenitor cell pools may play a role in the augmentation of HbF by 5-azacytidine

1984 • 53 citations

Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy [letter]

1994 • 51 citations

Treatment of baboon with vinblastine: insights into the mechanisms of pharmacologic stimulation of Hb F in the adult

1985 • 49 citations

Fetal gene reactivation

1998 • 48 citations

Fetal hemoglobin in acute and chronic states of erythroid expansion

1993 • 48 citations

Effects of Cell Density and Trichostatin A on the Expression ofHDAC1andp57Kip2in Hep 3B Cells

1998 • 46 citations

Fetal hemoglobin induction by acetate, a product of butyrate catabolism [see comments]

1994 • 45 citations

Activation of β-Globin Promoter by Erythroid Krüppel-Like Factor

1998 • 44 citations

Effects of interleukin-3 and erythropoietin on in vivo erythropoiesis and F-cell formation in primates

1989 • 44 citations

Sickle cell anemia and trait in a population of southern india

1977 • 43 citations

Mechanism of Hb F stimulation by S-stage compounds. In vitro studies with bone marrow cells exposed to 5-azacytidine, Ara-C, or hydroxyurea.

1988 • 42 citations

Entrapment of purified alpha-hemoglobin chains in normal erythrocytes. A model for beta thalassemia.

1990 • 42 citations

Pharmacological Manipulation of Fetal Hemoglobin Synthesis in Patients with Severe β‐Thalassemia

1985 • 42 citations

Pathophysiology of α- and β-thalassemia: Therapeutic implications

2001 • 41 citations

The Thalassemia Repository (Ninth Edition; Part II)

1998 • 35 citations

Fetal Hemoglobin in Starvation Ketosis of Young Women

1998 • 27 citations

Erythroid Krüppel-Like Factor Is Essential for β-Globin Gene Expression Even in Absence of Gene Competition, But Is Not Sufficient to Induce the Switch From γ-Globin to β-Globin Gene Expression

1998 • 27 citations

Regulation of Human Globin Gene Switching

1993 • 27 citations

Cloning and Characterization of the Mouse Histone Deacetylase-2 Gene

1998 • 25 citations

Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression

2003 • 23 citations

The G and A hemoglobin chains during human fetal development.

1973 • 22 citations

Fetal Hemoglobin in Starvation Ketosis of Young Women

1998 • 20 citations

Fetal hemoglobin production in adult baboons by 5-azacytidine or by phenylhydrazine-induced hemolysis is associated with hypomethylation of globin gene DNA.

1983 • 19 citations

Hemoglobin switching in sheep.

1980 • 18 citations

Induction of Hemoglobin F Synthesis in Patients with β Thalassemia

1985 • 17 citations

Isolation and mapping of a human gene (RPD3L1) that is homologous to <i>RPD3</i>, a transcription factor in <i>Saccharomyces cerevisia</i><i>e</i>

1996 • 16 citations

Pharmacological induction of foetal haemoglobin synthesis in sickle-cell disease

1997 • 6 citations

Hemoglobin Switching

2001 • 6 citations