Btk Is Required for an Efficient Response to Erythropoietin and for SCF-controlled Protection against TRAIL in Erythroid Progenitors

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts

2001 • 691 citations

Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1

1999 • 388 citations

Caspase Activation Is Required for Terminal Erythroid Differentiation

2001 • 383 citations

The Pseudokinase Domain Is Required for Suppression of Basal Activity of Jak2 and Jak3 Tyrosine Kinases and for Cytokine-inducible Activation of Signal Transduction

2002 • 309 citations

Apoptotic Role of Fas/Fas Ligand System in the Regulation of Erythropoiesis

1999 • 262 citations

A role for tumour necrosis factor‐α, Fas and Fas‐Ligand in marrow failure associated with myelodysplastic syndrome

1998 • 243 citations

The Glucocorticoid Receptor Cooperates With the Erythropoietin Receptor and c-Kit to Enhance and Sustain Proliferation of Erythroid Progenitors In Vitro

1999 • 240 citations

Signaling network of the Btk family kinases

2000 • 230 citations

Signal Transduction in the Erythropoietin Receptor System

1999 • 227 citations

Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by ts mutants of avian erythroblastosis virus

1982 • 220 citations

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

1997 • 192 citations

Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors

1997 • 189 citations

Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.

1996 • 177 citations

The Src-selective Kinase Inhibitor PP1 Also Inhibits Kit and Bcr-Abl Tyrosine Kinases

2003 • 174 citations

TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis

2000 • 170 citations

BTK as a Mediator of Radiation-Induced Apoptosis in DT-40 Lymphoma B Cells

1996 • 166 citations

Fas Ligand Is Present in Human Erythroid Colony-Forming Cells and Interacts With Fas Induced by Interferon γ to Produce Erythroid Cell Apoptosis

1998 • 158 citations

The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors

1997 • 157 citations

Tec Kinases

2000 • 151 citations

Apoptosis Protection by the Epo Target Bcl-XL Allows Factor-Independent Differentiation of Primary Erythroblasts

2002 • 146 citations

Etk/Bmx as a Tumor Necrosis Factor Receptor Type 2-Specific Kinase: Role in Endothelial Cell Migration and Angiogenesis

2002 • 143 citations

In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis

2002 • 142 citations

Tumor necrosis factor (TNF)-alpha directly inhibits human erythropoiesis in vitro: role of p55 and p75 TNF receptors

1995 • 138 citations

PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

2003 • 135 citations

Interaction between the Btk PH Domain and Phosphatidylinositol-3,4,5-trisphosphate Directly Regulates Btk

2001 • 133 citations

BLNK mediates Syk-dependent Btk activation

2001 • 132 citations

KIT SIGNAL TRANSDUCTION

2000 • 130 citations

Bruton's Tyrosine Kinase as an Inhibitor of the Fas/CD95 Death-inducing Signaling Complex

1999 • 124 citations

Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis

2001 • 121 citations

X-Linked Agammaglobulinemia

2000 • 120 citations

An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells

2000 • 111 citations

Negative regulation of erythroblast maturation by Fas-L+/TRAIL+ highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma

2002 • 105 citations

Erythropoietin-Induced Activation of STAT5 Is Impaired in the Myelodysplastic Syndrome

1997 • 98 citations

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

1997 • 97 citations

Stem cell factor induces phosphatidylinositol 3′-kinase–dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells

2000 • 96 citations

Protein Kinase C α Controls Erythropoietin Receptor Signaling

2000 • 79 citations

Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: apoptotic cells recovered from high-density fraction of bone marrow aspirates

2000 • 79 citations

Raf-1 Antagonizes Erythroid Differentiation by Restraining Caspase Activation

2002 • 78 citations

Early events in erythropoietin-induced signaling.

1996 • 70 citations

Stem cell factor: laboratory and clinical aspects

2001 • 47 citations

Tec and Jak2 Kinases Cooperate to Mediate Cytokine-Driven Activation of c-fos Transcription

1998 • 45 citations

Intermolecular interactions between the SH3 domain and the proline‐rich TH region of Bruton's tyrosine kinase

2001 • 44 citations

The Solution Structure and Intramolecular Associations of the Tec Kinase Src Homology 3 Domain

2002 • 44 citations

Competing modes of self‐association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

2002 • 44 citations

A Novel Way to Induce Erythroid Progenitor Self Renewal: Cooperation of c-Kit with the Erythropoietin Receptor

1999 • 41 citations

ts-Oncogene-Transformed Erythroleukemic Cells: A Novel Test System for Purifying and Characterizing Avian Erythroid Growth Factors

1987 • 37 citations

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

2002 • 33 citations

Stem cell factor increases the expression of FLIP that inhibits IFNγ-induced apoptosis in human erythroid progenitor cells

2003 • 29 citations

Fas Antigen (CD95) in pure erythroid cell line AS-E2 is induced by interferon-γ and tumor necrosis factor-α and potentiates apoptotic death

1999 • 19 citations

Tyrosine kinase expression profiles of chicken erythro-progenitor cells and oncogene-transformed erythroblasts

1998 • 18 citations

BCR Engagement Induces Fas Resistance in Primary B Cells in the Absence of Functional Bruton’s Tyrosine Kinase

2002 • 17 citations