Nuclear lipid signalling

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

2001 • 3,629 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

2000 • 1,087 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

The Organization of Replication and Transcription

1999 • 750 citations

Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling

1998 • 719 citations

Back in the water: the return of the inositol phosphates

2001 • 626 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export

1999 • 524 citations

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1991 • 488 citations

Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum

1995 • 469 citations

The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase

1991 • 454 citations

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

1997 • 435 citations

A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control

2000 • 390 citations

Interphase Nuclei of Many Mammalian Cell Types Contain Deep, Dynamic, Tubular Membrane-bound Invaginations of the Nuclear Envelope

1997 • 365 citations

ATP-dependent accumulation and inositol trisphosphate- or cyclic ADP-ribose-mediated release of Ca2+ from the nuclear envelope

1995 • 364 citations

Regulation of Chromatin Remodeling by Inositol Polyphosphates

2003 • 349 citations

Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates

2003 • 336 citations

Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C δ1

2002 • 333 citations

Translocation of the 85-kDa Phospholipase A2 from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen

1995 • 331 citations

Phosphoinositide Signaling Pathways in Nuclei Are Associated with Nuclear Speckles Containing Pre-mRNA Processing Factors

1998 • 328 citations

Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells

1992 • 321 citations

Differential Nuclear and Cytoplasmic Expression of PTEN in Normal Thyroid Tissue, and Benign and Malignant Epithelial Thyroid Tumors

2000 • 321 citations

Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation

1987 • 310 citations

Phospholipase C isozymes selectively couple to specific neurotransmitter receptors

1997 • 302 citations

Lamins: building blocks or regulators of gene expression?

2002 • 288 citations

A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix.

1992 • 278 citations

Cytomegalovirus Recruitment of Cellular Kinases to Dissolve the Nuclear Lamina

2002 • 274 citations

Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ

1998 • 256 citations

Selective translocation of beta II-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells.

1991 • 251 citations

Nuclear localization of prostaglandin E ₂ receptors

1998 • 240 citations

Searching for a function for nuclear actin

2000 • 235 citations

Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C δ1

2002 • 232 citations

A Role for Nuclear PTEN in Neuronal Differentiation

2000 • 228 citations

Remodelling the walls of the nucleus

2002 • 223 citations

Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing

2001 • 210 citations

The Role of Carboxyl-terminal Basic Amino Acids in Gqα-dependent Activation, Particulate Association, and Nuclear Localization of Phospholipase C-β1

1996 • 198 citations

Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.

1994 • 195 citations

The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system

2002 • 183 citations

Nuclear calcium signalling by individual cytoplasmic calcium puffs

1997 • 181 citations

A comparison of the molecular species compositions of mammalian lung surfactant phospholipids

2001 • 176 citations

Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform β1 is specifically, but not predominantly, located in the nucleus

1993 • 165 citations

Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE

2002 • 158 citations

Phospholipid signalling in the nucleus

1998 • 153 citations

A Role for Nuclear Phospholipase Cβ1 in Cell Cycle Control

2000 • 153 citations

Functional compartmentalization of the nucleus

1996 • 145 citations

PIKE

2000 • 144 citations

βII Protein Kinase C Is Required for the G2/M Phase Transition of Cell Cycle

1996 • 143 citations

Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells

2001 • 134 citations

Mechanisms controlling gene expression by nuclear calcium signals

1998 • 134 citations

Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons.

1993 • 133 citations

Evidence That a Phosphatidylinositol 3,4,5-Trisphosphate-binding Protein Can Function in Nucleus

1999 • 130 citations

Translocation of cytosolic phospholipase A2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis

1996 • 125 citations

Nuclear Lipid Signaling

2002 • 125 citations

A New Phospholipase C δ4 Is Induced at S-phase of the Cell Cycle and Appears in the Nucleus

1996 • 124 citations

“Tell Me Where Is Calcium Bred”: Clarifying the Roles of Nuclear Calcium

1998 • 121 citations

Metabolism and possible compartmentalization of inositol lipids in isolated rat-liver nuclei

1997 • 119 citations

Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells.

1994 • 119 citations

Nuclear diacylglycerol is increased during cell proliferation in vivo

1993 • 119 citations

Phosphorylation of rat liver nuclear envelopes. I. Characterization of in vitro protein phosphorylation.

1983 • 115 citations

Highly Saturated Endonuclear Phosphatidylcholine Is Synthesizedin Situ and Colocated with CDP-choline Pathway Enzymes

2001 • 114 citations

Phosphatidylinositol 5-Phosphate Biosynthesis Is Linked to PIKfyve and Is Involved in Osmotic Response Pathway in Mammalian Cells

2002 • 114 citations

A Role for Nuclear Phosphatidylinositol-specific Phospholipase C in the G2/M Phase Transition

1997 • 113 citations

Phosphatidylinositol 4,5‐bisphosphate reverses the inhibition of RNA transcription caused by histone H1

1998 • 110 citations

Alpha-thrombin stimulates nuclear diglyceride levels and differential nuclear localization of protein kinase C isozymes in IIC9 cells.

1992 • 110 citations

PIPkins1We introduce here the abbreviation PIPkin (an abbreviation we have used in our lab for years) for cogent reasons. Previously, PtdIns4P 5-kinase was the favoured abbreviation, but in view of the extensive revision and uncertainty as to substrates and products that we discuss in this review, only PtdInsP kinase would now suffice. Moreover, we have recently recorded evidence that type II PIPkin is subject to multiple phosphorylations by protein kinases [1]. As we progress in our …

1998 • 110 citations

Phosphorylation of Nuclear Phospholipase C β1 by Extracellular Signal-Regulated Kinase Mediates the Mitogenic Action of Insulin-Like Growth Factor I

2001 • 108 citations

Increase in nuclear phosphatidylinositol 3‐kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC‐ζ translocation to the nucleus of NGF‐treated PC12 cells

1999 • 107 citations

Molecular Cloning, Splice Variants, Expression, and Purification of Phospholipase C-δ;4

1996 • 106 citations

Two forms of phospholipase C-beta 1 generated by alternative splicing.

1994 • 106 citations

Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells

2001 • 103 citations

Nuclear targeting of the β isoform of Type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its α-helix 7

2000 • 101 citations

Rapid changes in phospholipid metabolism in the nuclei of Swiss 3T3 cells induced by treatment of the cells with insulin-like growth factor I

1988 • 100 citations

Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor

1990 • 99 citations

Nuclear Diacylglycerol Produced by Phosphoinositide-specific Phospholipase C Is Responsible for Nuclear Translocation of Protein Kinase C-α

1998 • 98 citations

Changes in either Cytosolic or Nucleoplasmic Inositol 1,4,5-Trisphosphate Levels Can Control Nuclear Ca2+ Concentration

1995 • 98 citations

Nuclear calcium signalling

2000 • 97 citations

Phosphatidylinositol 3-Kinase C2α Contains a Nuclear Localization Sequence and Associates with Nuclear Speckles

2001 • 95 citations

Effects of 1-methyladenine on nuclear Ca2* transients and meiosis resumption in starfish oocytes are mimicked by the nuclear injection of inositol 1,4,5-trisphosphate and cADP-ribose

1997 • 94 citations

Nuclear phospholipase C and signaling

2001 • 93 citations

Association of Phosphatidylinositol 3-Kinase with Nuclear Transcription Sites in Higher Plants

2000 • 90 citations

Essential role for nuclear phospholipase C beta1 in insulin-like growth factor I-induced mitogenesis.

1997 • 89 citations

Phospholipid interactions in rat liver nuclear matrix

1980 • 87 citations

Fluorescently Labeled Phosphatidylinositol Transfer Protein Isoforms (α and β), Microinjected into Fetal Bovine Heart Endothelial Cells, Are Targeted to Distinct Intracellular Sites

1996 • 85 citations

Nuclei contain two differentially regulated pools of diacylglycerol

1999 • 83 citations

Phosphoinositide 3-Kinase in Rat Liver Nuclei

1998 • 78 citations

Nuclear but not cytoplasmic phospholipase C beta 1 inhibits differentiation of erythroleukemia cells.

1998 • 76 citations

Localization of two forms of phospholipase C-β1, a and b, in C6Bu-1 cells

1998 • 76 citations

A possible role of nuclear ceramide and sphingosine in hepatocyte apoptosis in rat liver

1999 • 76 citations

Phospholipids in the nucleus—metabolism and possible functions

1992 • 75 citations

Phosphatidylglycerol Is a Physiologic Activator of Nuclear Protein Kinase C

1998 • 75 citations

Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mitogenic stimulation with insulin-like growth factor I and bombesin: Translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides

1991 • 70 citations

Phospholipase C-δ1 Contains a Functional Nuclear Export Signal Sequence

1999 • 68 citations

Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-βII at G2/M

2002 • 67 citations

.alpha.-Thrombin-induced nuclear sn-1,2-diacylglycerols are derived from phosphatidylcholine hydrolysis in cultured fibroblasts

1994 • 65 citations

Agonists Cause Nuclear Translocation of Phosphatidylinositol 3-Kinase γ

1999 • 64 citations

Co-localization of Leukotriene A4Hydrolase with 5-Lipoxygenase in Nuclei of Alveolar Macrophages and Rat Basophilic Leukemia Cells but Not Neutrophils

2001 • 63 citations

Changes in the components of a nuclear inositide cycle during differentiation in murine erythroleukaemia cells

1995 • 62 citations

The G‐protein G _i regulates mitosis but not DNA synthesis in growth factor‐activated fibroblasts: a role for the nuclear translocation of G _i

1997 • 61 citations

Enhanced nuclear diacylglycerol kinase activity in response to a mitogenic stimulation of quiescent Swiss 3T3 cells with insulin-like growth factor I.

2000 • 59 citations

A novel phospholipase A2 associated with nuclear matrix: stimulation of the activity and modulation of the Ca2+ dependency by polyphosphoinositides

1989 • 56 citations

Protein Kinase C α-mediated Negative Feedback Regulation Is Responsible for the Termination of Insulin-like Growth Factor I-induced Activation of Nuclear Phospholipase C β1 in Swiss 3T3 Cells

2001 • 55 citations

Nuclear localization of phosphatidylinositol 4-kinase β

2002 • 55 citations

Existence of Mg2+-Dependent, Neutral Sphingomyelinase in Nuclei of Rat Ascites Hepatoma Cells1

1989 • 55 citations

Evidence that 3′‐phosphorylated polyphosphoinositides are generated at the nuclear surface: use of immunostaining technique with monoclonal antibodies specific for PI 3,4‐P₂

2000 • 55 citations

Nuclear localization of neutral sphingomyelinase 1: biochemical and immunocytochemical analyses

2001 • 54 citations

Cytoplasmic and Nuclear Phospholipase C-β1 Relocation: Role in Resumption of Meiosis in the Mouse Oocyte

2000 • 53 citations

Nuclear Localization of Enzymatically Active Green Fluorescent Protein-CTP:Phosphocholine Cytidylyltransferase α Fusion Protein Is Independent of Cell Cycle Conditions and Cell Types

2000 • 53 citations

Diacylglycerol kinases in nuclear lipid-dependent signal transduction pathways

2002 • 51 citations

Proliferating or Differentiating Stimuli Act on Different Lipid-dependent Signaling Pathways in Nuclei of Human Leukemia Cells

2002 • 51 citations

Insulin selectively stimulates nuclear phosphoinositide‐specific phospholipase C (PI‐PLC) β1 activity through a mitogen‐activated protein (MAP) kinase‐dependent serine phosphorylation

2000 • 51 citations

Molecular characterization of protein kinase C‐α binding to lamin A

2002 • 50 citations

Mapping of a Molecular Determinant for Protein Kinase C βII Isozyme Function

1998 • 50 citations

Nuclear location of PLA2-I in proliferative cells

1998 • 49 citations

Nuclear Diacylglycerol Kinase-θ Is Activated in Response to α-Thrombin

2001 • 48 citations

Src Homology Domains of Phospholipase C γ1 Inhibit Nerve Growth Factor‐Induced Differentiation of PC12 Cells

1998 • 44 citations

Presence and Activation of Nuclear Phosphoinositide 3-Kinase C2β during Compensatory Liver Growth

2001 • 44 citations

Characterization of a G Protein-activated Phosphoinositide 3-Kinase in Vascular Smooth Muscle Cell Nuclei

2001 • 44 citations

Separate Activation of the Cytoplasmic and Nuclear Calcium Pools in Maturing Starfish Oocytes

1998 • 44 citations

A novel pathway of cellular phosphatidylinositol(3,4,5)-trisphosphate synthesis is regulated by oxidative stress

2001 • 43 citations

Nuclear PLCβ1 acts as a negative regulator of p45/NF-E2 expression levels in Friend erythroleukemia cells

2002 • 43 citations

Insulin-like growth factor-I-dependent stimulation of nuclear phospholipase C-?1 activity in Swiss 3T3 cells requires an intact cytoskeleton and is paralleled by increased phosphorylation of the phospholipase

1999 • 39 citations

Novel biochemical and functional insights into nuclear Ca²⁺transport through IP₃Rs and RyRs in osteoblasts

2000 • 38 citations

The activation of nuclear phosphoinositide 3‐kinase C2β in all‐trans‐retinoic acid‐differentiated HL‐60 cells

2002 • 38 citations

The regulation of mitotic nuclear envelope breakdown: A role for multiple lamin kinases

1995 • 37 citations

Re‐examination of the mechanisms regulating nuclear inositol lipid metabolism

2001 • 36 citations

Spatiotemporal analysis of calcium dynamics in the nucleus of hamster oocytes.

1996 • 36 citations

Translocation of diacylglycerol kinase α to the nuclear matrix of rat thymocytes and peripheral T‐lymphocytes

1996 • 33 citations

Phosphoinositide Signalling in Nuclei of Friend Cells: DMSO-Induced Differentiation Reduces the Association of Phosphatidylinositol-Transfer Protein with the Nucleus

1997 • 31 citations

Protein Kinase C-βII Is an Apoptotic Lamin Kinase in Polyomavirus-transformed, Etoposide-treated pyF111 Rat Fibroblasts

2002 • 28 citations

Sphingosine Inhibits the Synthesis of RNA Primers by Primase in vitro

1994 • 26 citations

Nuclear inositol lipid signaling and its potential involvement in malignant transformation

2002 • 22 citations

Phospholipases in the nucleus

1997 • 19 citations

Nuclear Lipid Signaling

2002 • 6 citations