Nitric oxide generators produce accumulation of chelatable zinc in hippocampal neuronal perikarya

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem

1986 • 4,155 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

The biochemical basis of zinc physiology

1993 • 2,967 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

NO at work

1994 • 1,493 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

The Rat Brain. A Stereotaxic Atlas

1964 • 1,002 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Enzyme-independent formation of nitric oxide in biological tissues

1995 • 783 citations

Histochemical demonstration of heavy metals

1981 • 758 citations

Complexes of ^.NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects

1991 • 724 citations

A critical physiological role of zinc in the structure and function of biomembranes

1981 • 635 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders

1997 • 543 citations

A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain

1987 • 525 citations

Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases

1997 • 525 citations

Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)

1993 • 490 citations

Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

1997 • 486 citations

Nitric oxide generation from nitroprusside by vascular tissue

1991 • 461 citations

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

1993 • 461 citations

Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study

1985 • 410 citations

Kainate-induced apoptotic cell death in hippocampal neurons

1994 • 404 citations

Electron microscopical localization of the zinc in hippocampal mossy fibre synapses by a modified sulfide silver procedure

1967 • 393 citations

Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss

1995 • 356 citations

Translocation of zinc may contribute to seizure-induced death of neurons

1989 • 347 citations

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

1994 • 327 citations

Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat

1990 • 303 citations

A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease

1993 • 289 citations

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant

1997 • 287 citations

Neurobiology of Nitric Oxide

1996 • 281 citations

Nitric Oxide Destroys Zinc-Sulfur Clusters Inducing Zinc Release from Metallothionein and Inhibition of the Zinc Finger-Type Yeast Transcription Activator LAC9

1994 • 276 citations

Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains.

1991 • 268 citations

Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

1995 • 266 citations

Sensitivity of the Essential Zinc-Thiolate Moiety of Yeast Alcohol Dehydrogenase to Hypochlorite and Peroxynitrite

1995 • 246 citations

Zinc neurotoxicity in cortical cell culture

1988 • 244 citations

Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat

1996 • 242 citations

A simplified timm stain procedure compatible with formaldehyde fixation and routine paraffin embedding of rat brain

1982 • 222 citations

Selective release of endogenous zinc from the hippocampal mossy fibers in situ

1987 • 220 citations

Clinical Pharmacokinetics of Nitroprusside, Cyanide, Thiosulphate and Thiocyanate

1984 • 191 citations

Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity

1996 • 188 citations

NITRIC OXIDE ACTIONS IN NEUROCHEMISTRY

1996 • 184 citations

Nitric Oxide Synthase in Reactive Astrocytes Adjacent to β-Amyloid Plaques

1997 • 183 citations

Brief exposure to zinc is toxic to cortical neurons

1986 • 182 citations

A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation

1985 • 179 citations

A Novel Nonenzymatic Pathway for the Generation of Nitric Oxide by the Reaction of Hydrogen Peroxide and D- or L-Arginine

1997 • 178 citations

Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin

1994 • 177 citations

Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study

1988 • 175 citations

The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS

1985 • 171 citations

Zinc and Alzheimer's disease: is there a direct link?

1997 • 169 citations

β-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity

1996 • 168 citations

Microglial release of nitric oxide by the synergistic action of β-amyloid and IFN-γ

1995 • 165 citations

Nitric oxide mediates intracytoplasmic and intranuclear zinc release

1997 • 163 citations

Ischemic stress induces deposition of amyloid ? immunoreactivity in human brain

1995 • 156 citations

Spontaneous and evoked release of endogenous Zn2+ in the hippocampal mossy fiber zone of the rat in situ

1985 • 154 citations

Characterization of Zinc-Induced Neuronal Death in Primary Cultures of Rat Cerebellar Granule Cells

1997 • 142 citations

Accumulation of the β amyloid precursor protein at sites of ischemic injury in rat brain

1993 • 139 citations

Zinc alters excitatory amino acid neurotoxicity on cortical neurons

1988 • 139 citations

Zinc‐Induced Aggregation of Human and Rat β‐Amyloid Peptides In Vitro

1996 • 131 citations

L-Arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex

1993 • 119 citations

Apoptosis associated DNA fragmentation in epileptic brain damage

1994 • 114 citations

A β42 is the predominant form of amyloid b -protein in the brains of short-term survivors of head injury

1997 • 112 citations

Complete cerebral ischemia with short-term survival in rats induced by cardiac arrest. I. Extracellular accumulation of Alzheimer's β-amyloid protein precursor in the brain

1994 • 104 citations

Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide

1993 • 103 citations

Amyloid precursor protein accumulates in white matter at the margin of a focal ischaemic lesion

1997 • 93 citations

Inhibition of the Catalytic Activity of Alcohol Dehydrogenase by Nitric Oxide Is Associated with S Nitrosylation and the Release of Zinc

1996 • 91 citations

The autometallographic zinc-sulphide method. A new approach involvingin vivo creation of nanometer-sized zinc sulphide crystal lattices in zinc-enriched synaptic and secretory vesicles

1996 • 86 citations

In SituNitric Oxide (NO) Measurement by Modified Electrodes: NO Labilized by Photolysis of Metal Nitrosyl Complexes

1997 • 84 citations

The Amyloid Precursor Protein in Ischemic Brain Injury and Chronic Hypoperfusion^a

1993 • 84 citations

Cytotoxic Fragment of Amyloid Precursor Protein Accumulates in Hippocampus after Global Forebrain Ischemia

1996 • 83 citations

Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus.

1994 • 81 citations

Ketamine Antagonizes Nitric Oxide Release From Cerebral Cortex After Middle Cerebral Artery Ligation in Rats

1996 • 76 citations

Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins

1997 • 76 citations

Zinc, a neurotoxin to cultured neurons, contaminates cycad flour prepared by traditional guamanian methods

1992 • 74 citations

Cholinergic denervation-induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation

1984 • 69 citations

Expression of β-amyloid precursor protein mRNAs following transient focal ischaemia

1996 • 68 citations

Reductive metabolism of nitroprusside in rat hepatocytes and human erythrocytes

1991 • 66 citations

Brain lesions induced by specific and non-specific inhibitors of sodium-potassium ATPase

1994 • 60 citations

The neurotoxicity of zinc in the rat hippocampus

1990 • 57 citations

Selective Aggregation of Endogenous β‐Amyloid Peptide and Soluble Amyloid Precursor Protein in Cerebrospinal Fluid by Zinc

1997 • 54 citations

Prevention of zinc neurotoxicity in vivo by N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN)

1996 • 52 citations

Sodium nitroprusside blocks NMDA receptors via formation of ferrocyanide ions

1992 • 48 citations

Response : Zinc and Alzheimer's Disease

1995 • 45 citations

Accumulation of apolipoprotein E and β-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death

1996 • 45 citations

Hippocampal lesions induced by microinjection of the nitric oxide donor nitroprusside

1992 • 43 citations

Ethanol and Excitotoxicity in Cultured Cortical Neurons: Differential Sensitivity of N‐Methyl‐D‐Aspartate and Sodium Nitroprusside Toxicity

1992 • 42 citations

[25] Detection of nitric oxide interaction with zinc finger proteins

1996 • 40 citations

Zinc inhibits apoptosis upstream of ICE/CED-3 proteases rather than at the level of an endonuclease

1997 • 35 citations

Induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentation

1996 • 34 citations

Lack of Ca2+ involvement in thymocyte apoptosis induced by chelation of intracellular Zn2+.

1995 • 34 citations

Nitric oxide generation from sodium nitroprusside and hydroxylamine in brain

1997 • 30 citations

In vivo pharmacological study of spermine-induced neurotoxicity

1995 • 30 citations

Nitric Oxide and Derived Species as Toxic Agents in Stroke, AIDS Dementia, and Chronic Neurodegenerative Disorders

1997 • 27 citations

Neurotoxic effects of the intrastriatal injection of spermine and spermidine: lack of involvement of NMDA receptors

1992 • 27 citations

Differential effects of NBQX on the distal and local toxicity of glutamate agonists administered intra-hippocampally

1993 • 21 citations

Effects of nitric oxide donors sodium nitroprusside and 3-morpholino-sydnonimine on prolactin secretion in conscious rats

1996 • 18 citations

Early nitric oxide increase in depolarized tissue of cat focal cerebral ischaemia

1996 • 15 citations

The neurotoxicity of intrahippocampal kainic acid injection in rats is not accompanied by a reduction of Timm stain

1988 • 6 citations

Abnormal homeostasis of pH and Zinc: The prelude for cerebral Aβ amyloid formation?

1996 • 3 citations