L-type Ca2+ channel-mediated Zn2+ toxicity and modulation by ZnT-1 in PC12 cells11Published on the World Wide Web on 12 October 2000.
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References (57)
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
1976 • 5,526 citations
The biochemical basis of zinc physiology
1993 • 2,967 citations
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
1996 • 1,857 citations
Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
1987 • 1,280 citations
Release of endogenous Zn2+ from brain tissue during activity
1984 • 1,125 citations
Neurobiology of Zinc and Zinc-Containing Neurons
1989 • 1,075 citations
The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia
1996 • 1,057 citations
Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons
1987 • 852 citations
Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis
1995 • 834 citations
Stimulation-induced uptake and release of zinc in hippocampal slices
1984 • 812 citations
ZINC AND BRAIN INJURY
1998 • 757 citations
Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.
1995 • 746 citations
ZnT-3, a putative transporter of zinc into synaptic vesicles
1996 • 712 citations
Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons
1987 • 678 citations
Transition Metals in Control of Gene Expression
1993 • 629 citations
Biochemical Characteristics of Caspases-3, -6, -7, and -8
1997 • 536 citations
Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3
1997 • 486 citations
Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain
1993 • 481 citations
Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry
1997 • 463 citations
ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.
1996 • 447 citations
Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc
1994 • 445 citations
Zinc-Induced Cortical Neuronal Death: Contribution of Energy Failure Attributable to Loss of NAD+and Inhibition of Glycolysis
2000 • 354 citations
Regulation of the zinc transporter ZnT-1 by dietary zinc
1998 • 306 citations
Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat
1990 • 303 citations
The function of metallothionein
1995 • 299 citations
Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury
2000 • 285 citations
Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels
1994 • 284 citations
AMPA receptor activation potentiates zinc neurotoxicity
1993 • 280 citations
Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death
1992 • 270 citations
Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals
1999 • 270 citations
Disruption of the Metallothionein-III Gene in Mice: Analysis of Brain Zinc, Behavior, and Neuron Vulnerability to Metals, Aging, and Seizures
1997 • 248 citations
Zinc neurotoxicity in cortical cell culture
1988 • 244 citations
Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors
1994 • 223 citations
Metallothioneins in Brain—The Role in Physiology and Pathology
1997 • 201 citations
Brief exposure to zinc is toxic to cortical neurons
1986 • 182 citations
A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation
1985 • 179 citations
Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures
1999 • 177 citations
The influence of zinc on apoptosis.
1995 • 176 citations
Evidence for a protective role of metallothionein-1 in focal cerebral ischemia
1999 • 175 citations
The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS
1985 • 171 citations
Zinc has opposite effects on NMDA and Non-NMDA receptors expressed in xenopus oocytes
1990 • 165 citations
A Reappraisal of the Role of Zinc in Life and Death Decisions of Cells
1997 • 161 citations
Spontaneous and evoked release of endogenous Zn2+ in the hippocampal mossy fiber zone of the rat in situ
1985 • 154 citations
Measurement of Intracellular Free Zinc Concentrations Accompanying Zinc-Induced Neuronal Death
1999 • 151 citations
Characterization of Zinc-Induced Neuronal Death in Primary Cultures of Rat Cerebellar Granule Cells
1997 • 142 citations
Expression of Zinc Transporter Gene, ZnT-1, Is Induced after Transient Forebrain Ischemia in the Gerbil
1997 • 140 citations
Calcium antagonists High-affinity binding and inhibition of calcium transport in a clonal cell line.
1982 • 125 citations
Zn2+ permeates Ca2+permeable AMPA/kainate channels and triggers selective neural injury
1995 • 112 citations
Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat
1996 • 105 citations
Neurotrophin receptor structure and interactions
2000 • 102 citations
Nerve growth factor modulates the drug sensitivity of neurotransmitter release from PC-12 cells.
1986 • 84 citations
Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins
1997 • 76 citations
The neurotoxicity of zinc in the rat hippocampus
1990 • 57 citations
Distribution of terminal fields stained for zinc in the neocortex of the rat
1996 • 55 citations
Responses of pyriform cortex neurons to excitatory amino acids: Voltage dependence, conductance changes, and effects of divalent cations
1987 • 44 citations
Calcium channels in undifferentiated PC12 rat pheochromocytoma cells
1989 • 35 citations
Binding of a 1,4-dihydropyridine calcium channel activator, (−) S bay K 8644, to cardiac preparations
1989 • 33 citations