Mouse models in oncoimmunology

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

The Hallmarks of Cancer

2000 • 27,569 citations

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

2011 • 5,649 citations

The immune contexture in human tumours: impact on clinical outcome

2012 • 4,275 citations

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

2014 • 3,906 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

The Three Es of Cancer Immunoediting

2004 • 2,781 citations

Immunogenic Cell Death in Cancer Therapy

2012 • 2,753 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Immunogenic cell death and DAMPs in cancer therapy

2012 • 2,400 citations

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

2007 • 2,297 citations

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

2016 • 2,073 citations

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

2015 • 2,036 citations

Natural Innate and Adaptive Immunity to Cancer

2011 • 1,878 citations

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

2014 • 1,826 citations

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

2009 • 1,694 citations

Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2Rγnull Mice Engrafted with Mobilized Human Hemopoietic Stem Cells

2005 • 1,595 citations

Combining immunotherapy and targeted therapies in cancer treatment

2012 • 1,430 citations

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

2005 • 1,330 citations

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

2015 • 1,329 citations

Adaptive immunity maintains occult cancer in an equilibrium state

2007 • 1,307 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

2012 • 1,160 citations

Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial

2014 • 1,147 citations

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

2001 • 1,145 citations

MYC regulates the antitumor immune response through CD47 and PD-L1

2016 • 1,128 citations

Immunogenic death of colon cancer cells treated with oxaliplatin

2009 • 1,041 citations

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

2013 • 1,016 citations

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

2014 • 1,009 citations

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice

2005 • 870 citations

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

2012 • 855 citations

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

2016 • 830 citations

The Basis of Oncoimmunology

2016 • 721 citations

Development and function of human innate immune cells in a humanized mouse model

2014 • 674 citations

Translation of the Philadelphia chromosome into therapy for CML

2008 • 645 citations

The secret ally: immunostimulation by anticancer drugs

2012 • 642 citations

The mighty mouse: genetically engineered mouse models in cancer drug development

2006 • 631 citations

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

2010 • 550 citations

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

2000 • 540 citations

Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications

2009 • 532 citations

Expression of tumour-specific antigens underlies cancer immunoediting

2012 • 501 citations

Engineered In Vitro Disease Models

2015 • 495 citations

PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells

2004 • 476 citations

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

2016 • 444 citations

The Emperor of All Maladies: A Biography of Cancer

2010 • 428 citations

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

2012 • 406 citations

A dual role for autophagy in a murine model of lung cancer

2014 • 405 citations

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

2015 • 399 citations

Microbiome and Anticancer Immunosurveillance

2016 • 395 citations

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

2015 • 394 citations

FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis

2015 • 344 citations

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

2011 • 310 citations

Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells

2012 • 309 citations

Cancer immunoediting by the innate immune system in the absence of adaptive immunity

2012 • 306 citations

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

2011 • 305 citations

Immunologic Mechanisms in UV Radiation Carcinogenesis

1981 • 295 citations

50 Years of Preclinical Anticancer Drug Screening: Empirical to Target-Driven Approaches

2005 • 292 citations

Natural and therapy-induced immunosurveillance in breast cancer

2015 • 273 citations

Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies

2013 • 256 citations

Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

2011 • 237 citations

Transgenic expression of human signal regulatory protein alpha in Rag2^−/−γ_c^−/−mice improves engraftment of human hematopoietic cells in humanized mice

2011 • 214 citations

In vivo discovery of immunotherapy targets in the tumour microenvironment

2014 • 212 citations

Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells

2015 • 212 citations

CD73-Deficient Mice Are Resistant to Carcinogenesis

2012 • 192 citations

IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect

2011 • 189 citations

The Emperor of all Maladies: A Biography of Cancer

2011 • 184 citations

Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth

2010 • 181 citations

Defining the optimal murine models to investigate immune checkpoint blockers and their combination with other immunotherapies

2016 • 175 citations

Calreticulin Expression in Human Non–Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

2016 • 169 citations

Non-germline genetically engineered mouse models for translational cancer research

2010 • 167 citations

A Novel Chimeric Antigen Receptor Against Prostate Stem Cell Antigen Mediates Tumor Destruction in a Humanized Mouse Model of Pancreatic Cancer

2014 • 166 citations

Humanized hemato-lymphoid system mice

2015 • 155 citations

Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL

2013 • 154 citations

Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice

2015 • 153 citations

Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity

2012 • 152 citations

Immunological off-target effects of imatinib

2016 • 131 citations

Oncogene addiction

2004 • 129 citations

Characteristics of tertiary lymphoid structures in primary cancers

2013 • 119 citations

Targeted Activation of Human Vγ9Vδ2-T Cells Controls Epstein-Barr Virus-Induced B Cell Lymphoproliferative Disease

2014 • 115 citations

Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti–CTLA-4 antibodies

2005 • 109 citations

Human major histocompatibility complex class II-restricted T cell responses in transgenic mice.

1994 • 108 citations

Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis

2013 • 104 citations

Combinatorial Cancer Immunotherapies

2016 • 102 citations

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice

2015 • 90 citations

Long-Term Engraftment and Expansion of Tumor-Derived Memory T Cells Following the Implantation of Non-Disrupted Pieces of Human Lung Tumor into NOD-scid IL2Rγnull Mice

2008 • 90 citations

Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice

2012 • 87 citations

Cancer-driven dynamics of immune cells in a microfluidic environment

2014 • 78 citations

γ9 and δ2CDR3 domains regulate functional avidity of T cells harboring γ9δ2TCRs

2012 • 77 citations

Multiple cancers. Tumor burden permits the outgrowth of other cancers.

1985 • 74 citations

Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo

2009 • 64 citations

Progressive loss of anti-HER2 CD4⁺ T-helper type 1 response in breast tumorigenesis and the potential for immune restoration

2015 • 64 citations

Imiquimod Inhibits Melanoma Development by Promoting pDC Cytotoxic Functions and Impeding Tumor Vascularization

2014 • 62 citations

Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo

2015 • 60 citations

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

2011 • 56 citations

Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells

2013 • 41 citations

Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice

2016 • 39 citations

Mouse Models of Tumor Immunotherapy

2016 • 37 citations

“Glowing Head” Mice: A Genetic Tool Enabling Reliable Preclinical Image-Based Evaluation of Cancers in Immunocompetent Allografts

2014 • 36 citations

Humanized Mice to Study FcγR Function

2014 • 31 citations

HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice

2014 • 30 citations

IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity

2015 • 29 citations

Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model.

2013 • 21 citations

Inhibition of formyl peptide receptor 1 reduces the efficacy of anticancer chemotherapy against carcinogen-induced breast cancer

2016 • 20 citations

Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer

2009 • 15 citations

Generation of improved mouse models for the study of hepatitis C virus

2015 • 14 citations

Morphometric analysis of immunoselection against hyperploid cancer cells

2015 • 11 citations

Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate

2015 • 11 citations