Mouse Models of Tumor Immunotherapy

Hallmarks of Cancer: The Next Generation

2011 • 58,651 citations

The Hallmarks of Cancer

2000 • 27,569 citations

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

2012 • 14,648 citations

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

2012 • 11,574 citations

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

2015 • 7,057 citations

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

2011 • 5,649 citations

Development and Applications of CRISPR-Cas9 for Genome Engineering

2014 • 5,136 citations

Nivolumab in Previously Untreated Melanoma withoutBRAFMutation

2014 • 4,953 citations

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

2014 • 4,841 citations

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

2014 • 4,720 citations

The immune contexture in human tumours: impact on clinical outcome

2012 • 4,275 citations

Nivolumab plus Ipilimumab in Advanced Melanoma

2013 • 4,054 citations

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

2014 • 3,906 citations

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

2014 • 3,320 citations

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

2013 • 3,290 citations

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

2011 • 3,283 citations

CRISPR-Cas systems for editing, regulating and targeting genomes

2014 • 2,948 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

Immunogenic Cell Death in Cancer Therapy

2012 • 2,753 citations

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

2011 • 2,514 citations

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

2014 • 2,254 citations

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

2015 • 2,154 citations

Natural Innate and Adaptive Immunity to Cancer

2011 • 1,878 citations

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

2014 • 1,826 citations

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

2014 • 1,775 citations

Adoptive immunotherapy for cancer: harnessing the T cell response

2012 • 1,570 citations

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

2011 • 1,515 citations

Immune surveillance of tumors

2007 • 1,325 citations

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

2011 • 1,191 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

2012 • 1,180 citations

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

2012 • 1,160 citations

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

2015 • 1,149 citations

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

2014 • 1,115 citations

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

2014 • 1,053 citations

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

2013 • 1,019 citations

IL-23 promotes tumour incidence and growth

2006 • 968 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Mechanisms in the Pathogenesis of Asbestosis and Silicosis

1998 • 913 citations

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

2014 • 843 citations

Tumor-specific Th17-polarized cells eradicate large established melanoma

2008 • 792 citations

Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma

2013 • 777 citations

CRISPR-mediated direct mutation of cancer genes in the mouse liver

2014 • 725 citations

Rituximab: Mechanism of Action

2010 • 707 citations

Maximizing mouse cancer models

2007 • 699 citations

Development and function of human innate immune cells in a humanized mouse model

2014 • 674 citations

Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century

2005 • 669 citations

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

2014 • 633 citations

Phase II and Phase III attrition rates 2011–2012

2013 • 632 citations

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

2013 • 629 citations

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

2014 • 602 citations

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

2011 • 598 citations

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

2014 • 582 citations

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

2014 • 542 citations

The Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity

2010 • 533 citations

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

2010 • 530 citations

Expression of tumour-specific antigens underlies cancer immunoediting

2012 • 501 citations

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido

2011 • 500 citations

Inducible in vivo genome editing with CRISPR-Cas9

2015 • 459 citations

Type I and type II Fc receptors regulate innate and adaptive immunity

2014 • 456 citations

Classification of current anticancer immunotherapies

2014 • 431 citations

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

2014 • 424 citations

Cancer and the gut microbiota: An unexpected link

2015 • 411 citations

Identification of Tyrosinase-related Protein 2 as a Tumor Rejection Antigen for the B16 Melanoma

1997 • 405 citations

Rapid modelling of cooperating genetic events in cancer through somatic genome editing

2014 • 391 citations

The Makings of a Tumor Rejection Antigen

1999 • 389 citations

Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4⁺T lymphocytes

1999 • 383 citations

Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy

2000 • 349 citations

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+ Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

2012 • 331 citations

What's wrong with our cancer models?

2005 • 323 citations

Examining the utility of patient-derived xenograft mouse models

2015 • 322 citations

Mouse models of breast cancer metastasis

2006 • 315 citations

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

2013 • 314 citations

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

2011 • 305 citations

Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

2013 • 303 citations

Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

2008 • 295 citations

Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature

2013 • 290 citations

Features of responding T cells in cancer and chronic infection

2010 • 288 citations

Monoclonal TCR-redirected tumor cell killing

2012 • 280 citations

Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

2012 • 265 citations

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

2013 • 265 citations

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

2009 • 263 citations

Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma

2010 • 257 citations

Translational value of mouse models in oncology drug development

2015 • 256 citations

Eradication of established tumors in mice by a combination antibody-based therapy

2006 • 252 citations

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase

2003 • 242 citations

Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

2011 • 237 citations

Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor

2014 • 226 citations

Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer

2012 • 221 citations

Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation

2011 • 217 citations

Trastuzumab causes antibody-dependent cellular cytotoxicity–mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance

2007 • 214 citations

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

2009 • 204 citations

Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcγRI, FcγRIII, and FcγRIV

2008 • 203 citations

Simple and Rapid In Vivo Generation of Chromosomal Rearrangements using CRISPR/Cas9 Technology

2014 • 202 citations

A clinically relevant, syngeneic model of spontaneous, highly metastatic B16 mouse melanoma.

2010 • 194 citations

CD73-Deficient Mice Are Resistant to Carcinogenesis

2012 • 192 citations

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

2014 • 169 citations

NLRP3 Suppresses NK Cell–Mediated Responses to Carcinogen-Induced Tumors and Metastases

2012 • 168 citations

Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL

2013 • 154 citations

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis

2010 • 134 citations

Experimental mouse tumour models: what can be learnt about human cancer immunology?

2011 • 126 citations

Humanized Mouse Model of Ovarian Cancer Recapitulates Patient Solid Tumor Progression, Ascites Formation, and Metastasis

2011 • 116 citations

Immune-Based Antitumor Effects of BRAF Inhibitors Rely on Signaling by CD40L and IFNγ

2014 • 116 citations

Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rγnull mouse model

2008 • 114 citations

Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy

2013 • 114 citations

Concise Review: Humanized Models of Tumor Immunology in the 21st Century: Convergence of Cancer Research and Tissue Engineering

2015 • 109 citations

Mouse Genome Engineering via CRISPR-Cas9 for Study of Immune Function

2015 • 105 citations

Humanized tumor mice—A new model to study and manipulate the immune response in advanced cancer therapy

2011 • 100 citations

Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8 ⁺ T Lymphocytes

2008 • 94 citations

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis

2013 • 91 citations

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice

2015 • 90 citations

Humanized NOD-SCID IL2rg –/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

2013 • 89 citations

Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer

2013 • 87 citations

Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response

2013 • 83 citations

Selective Permeabilization of the Blood–Brain Barrier at Sites of Metastasis

2013 • 81 citations

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma

2012 • 77 citations

Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma

2012 • 77 citations

Targeting stroma to treat cancers

2011 • 71 citations

NLRP3 promotes inflammation‐induced skin cancer but is dispensable for asbestos‐induced mesothelioma

2012 • 70 citations

Improved mouse models to assess tumour immunity and irAEs after combination cancer immunotherapies

2014 • 68 citations

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

2013 • 67 citations

Activating Fc Receptors Are Required for Antitumor Efficacy of the Antibodies Directed toward CD25 in a Murine Model of Adult T-Cell Leukemia

2004 • 65 citations

Perioperative Influenza Vaccination Reduces Postoperative Metastatic Disease by Reversing Surgery-Induced Dysfunction in Natural Killer Cells

2013 • 64 citations

Regulated Expression of a Tumor-Associated Antigen Reveals Multiple Levels of T-Cell Tolerance in a Mouse Model of Lung Cancer

2008 • 49 citations

Anti-IL-23 Monoclonal Antibody Synergizes in Combination with Targeted Therapies or IL-2 to Suppress Tumor Growth and Metastases

2011 • 47 citations

Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response

2008 • 46 citations

Cell-Death-Associated Molecular Patterns As Determinants of Cancer Immunogenicity

2013 • 42 citations

Glial Activation in the Early Stages of Brain Metastasis: TSPO as a Diagnostic Biomarker

2014 • 41 citations

Generation and utility of genetically humanized mouse models

2013 • 39 citations

Can you trust your animal study data?

2014 • 34 citations

The delicate balance of melanoma immunotherapy

2013 • 26 citations

The littlest patient

2014 • 18 citations

SnapShot: Genetic Mouse Models of Cancer

2007 • 12 citations

The potential impact of mouse model selection in preclinical evaluation of cancer immunotherapy

2014 • 8 citations