Immunogenic cell death and DAMPs in cancer therapy

Hallmarks of Cancer: The Next Generation

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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The landscape of somatic copy-number alteration across human cancers

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

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Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

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A census of human cancer genes

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Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

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Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

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Calreticulin exposure dictates the immunogenicity of cancer cell death

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Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

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Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

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PI3K pathway alterations in cancer: variations on a theme

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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

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Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

2009 • 1,449 citations

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

2000 • 1,385 citations

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

2005 • 1,331 citations

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

2005 • 1,330 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Cancer despite immunosurveillance: immunoselection and immunosubversion

2006 • 1,263 citations

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

2011 • 1,226 citations

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases

2000 • 1,200 citations

Clostridium difficileToxins: Mechanism of Action and Role in Disease

2005 • 1,103 citations

Immunogenic and tolerogenic cell death

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Immunogenic death of colon cancer cells treated with oxaliplatin

2009 • 1,041 citations

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

2010 • 1,006 citations

mRNA Is an Endogenous Ligand for Toll-like Receptor 3

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A2A adenosine receptor protects tumors from antitumor T cells

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Systemic effects of local radiotherapy

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High mobility group box 1 protein interacts with multiple Toll-like receptors

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The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance

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Endogenous HMGB1 regulates autophagy

2010 • 858 citations

The Inflammatory Response to Cell Death

2008 • 833 citations

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

2009 • 743 citations

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

2012 • 725 citations

Pattern recognition receptors and control of adaptive immunity

2008 • 713 citations

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

2012 • 706 citations

Chemotherapy-Associated Oxidative Stress: Impact on Chemotherapeutic Effectiveness

2004 • 702 citations

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

2012 • 698 citations

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

2009 • 662 citations

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

2009 • 657 citations

Endoplasmic reticulum stress responses

2007 • 642 citations

The secret ally: immunostimulation by anticancer drugs

2012 • 642 citations

Evolutionary dynamics of carcinogenesis and why targeted therapy does not work

2012 • 638 citations

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

2012 • 626 citations

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

2011 • 613 citations

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

2008 • 600 citations

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

2011 • 599 citations

HMGB1 is an endogenous immune adjuvant released by necrotic cells

2004 • 576 citations

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

2008 • 572 citations

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy

2007 • 531 citations

Extracellular adenosine triphosphate and adenosine in cancer

2010 • 531 citations

Decoding Cell Death Signals in Inflammation and Immunity

2010 • 519 citations

The extracellular release of HMGB1 during apoptotic cell death

2006 • 509 citations

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

2011 • 504 citations

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

2011 • 499 citations

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

2009 • 472 citations

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

2004 • 462 citations

Reactive Oxygen Species Generation and Mitochondrial Dysfunction in the Apoptotic Response to Bortezomib, a Novel Proteasome Inhibitor, in Human H460 Non-small Cell Lung Cancer Cells

2003 • 458 citations

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

2011 • 445 citations

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

2008 • 426 citations

Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)

2011 • 394 citations

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

2012 • 380 citations

Targeting ER stress induced apoptosis and inflammation in cancer

2010 • 375 citations

Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress

2010 • 374 citations

Calreticulin: non‐endoplasmic reticulum functions in physiology and disease

2009 • 371 citations

ER stress-induced inflammation: does it aid or impede disease progression?

2012 • 370 citations

Bortezomib enhances dendritic cell (DC)–mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications

2007 • 367 citations

F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells

2012 • 362 citations

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

2010 • 353 citations

Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function

2004 • 351 citations

Shikonin circumvents cancer drug resistance by induction of a necroptotic death

2007 • 350 citations

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response

2011 • 347 citations

CD73: a potent suppressor of antitumor immune responses

2012 • 339 citations

“Of mice and men”

2004 • 338 citations

Approval Summary for Bortezomib for Injection in the Treatment of Multiple Myeloma

2004 • 333 citations

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll‐like receptor 9 in mice

2011 • 332 citations

Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

2010 • 327 citations

Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis

2010 • 324 citations

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

2008 • 319 citations

NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1

2005 • 319 citations

Clearance of apoptotic and necrotic cells and its immunological consequences

2006 • 312 citations

Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils.

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Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX

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Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

1995 • 288 citations

Inhibitory Effects of Apoptotic Cell Ingestion upon Endotoxin-Driven Myeloid Dendritic Cell Maturation

2002 • 285 citations

Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy

2011 • 278 citations

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

2010 • 276 citations

RAGE: A Single Receptor for Several Ligands and Different Cellular Responses: The Case of Certain S100 Proteins

2007 • 270 citations

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

2011 • 269 citations

Photodynamic Therapy–Induced Cell Surface Expression and Release of Heat Shock Proteins: Relevance for Tumor Response

2005 • 266 citations

Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation

2007 • 258 citations

Quantitation of Doxorubicin Uptake, Efflux, and Modulation of Multidrug Resistance (MDR) in MDR Human Cancer Cells

2007 • 257 citations

Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype.

1997 • 254 citations

Chemotherapy induces ATP release from tumor cells

2009 • 252 citations

Cyclophosphamide Enhances the Antitumor Efficacy of Adoptively Transferred Immune Cells through the Induction of Cytokine Expression, B-Cell and T-Cell Homeostatic Proliferation, and Specific Tumor Infiltration

2007 • 245 citations

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

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Antitumor Activity of Gemcitabine and Oxaliplatin Is Augmented by Thymoquinone in Pancreatic Cancer

2009 • 242 citations

Modulating stress responses by the UPRosome: A matter of life and death

2011 • 240 citations

Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma

2012 • 234 citations

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells

2008 • 221 citations

Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance

2010 • 214 citations

Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma

2012 • 204 citations

CD73-Deficient Mice Are Resistant to Carcinogenesis

2012 • 192 citations

Isolation of Sarcoplasmic Reticulum Proteins

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A Perspective on Mammalian Caspases as Positive and Negative Regulators of Inflammation

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Caspase-8 in cancer biology and therapy

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Immunoselective Pressure and Human Leukocyte Antigen Class I Antigen Machinery Defects in Microsatellite Unstable Colorectal Cancers

2005 • 161 citations

Toll like receptor‐9 agonists stimulate prostate cancer invasion in vitro

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Natural endogenous adjuvants

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Inhibition of eIF2α Dephosphorylation Maximizes Bortezomib Efficiency and Eliminates Quiescent Multiple Myeloma Cells Surviving Proteasome Inhibitor Therapy

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Innate apoptotic immunity: the calming touch of death

2008 • 140 citations

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses

2011 • 140 citations

Up-regulation of Cyclooxygenase-2 and Apoptosis Resistance by p38 MAPK in Hypericin-mediated Photodynamic Therapy of Human Cancer Cells

2003 • 138 citations

Extracellular HMGB1 as a Proinflammatory Cytokine

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DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown

2011 • 136 citations

Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radioresistance

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Human platelets exhibit chemotaxis using functional N-formyl peptide receptors

2005 • 118 citations

Can NF-κB be a target for novel and efficient anti-cancer agents?

2006 • 118 citations

DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis

2008 • 117 citations

Severity of doxorubicin‐induced small intestinal mucositis is regulated by the TLR‐2 and TLR‐9 pathways

2011 • 114 citations

CIP2A is a target of bortezomib in human triple negative breast cancer cells

2012 • 114 citations

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

2011 • 113 citations

Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine

2012 • 111 citations

Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins

2005 • 109 citations

The Tumor Microenvironment: Characterization, Redox Considerations, and Novel Approaches for Reactive Oxygen Species-Targeted Gene Therapy

2012 • 108 citations

Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA

2012 • 104 citations

Necrosis is associated with IL-6 production but apoptosis is not

2005 • 103 citations

HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression

2007 • 103 citations

Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma

2012 • 103 citations

A case of mistaken identity: HSPs are no DAMPs but DAMPERs

2011 • 102 citations

Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: insight from ATP determination with the intravascular microdialysis technique

2011 • 101 citations

Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediates Resistance to Mitoxantrone via Glutathione-Dependent Drug Efflux

2006 • 100 citations

Activation of nuclear factor-κ B is linked to resistance to neoadjuvant chemotherapy in breast cancer patients

2006 • 97 citations

Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death

2012 • 97 citations

Extracellular/Microenvironmental Redox State

2009 • 96 citations

The emergence of phox-ER stress induced immunogenic apoptosis

2012 • 96 citations

A Mechanism of Release of Calreticulin from Cells During Apoptosis

2010 • 95 citations

Bortezomib Induces Nuclear Translocation of IκBα Resulting in Gene-Specific Suppression of NF-κB–Dependent Transcription and Induction of Apoptosis in CTCL

2011 • 95 citations

Dendritic Cell Therapy of High‐Grade Gliomas

2009 • 94 citations

Cell Death in the Maintenance and Abrogation of Tolerance: The Five Ws of Dying Cells

2011 • 90 citations

Metabolism of P2 Receptor Agonists in Human Airways

2004 • 87 citations

After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes

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Induction of Immunogenic Apoptosis by Blockade of Epidermal Growth Factor Receptor Activation with a Specific Antibody

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Adriamycin and daunorubicin: a comparison of antitumor activities and tissue uptake in mice following immunosuppression.

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Anticancer activities of adenine nucleotides in mice are mediated through expansion of erythrocyte ATP pools.

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Targeting Cancer-initiating Cells With Oncolytic Viruses

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Mutational and expressional analyses of ATG5, an autophagy-related gene, in gastrointestinal cancers

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Functional expression of TLR9 is associated to the metastatic potential of human lung cancer cell

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Specific Recognition of Apoptotic Cells Reveals a Ubiquitous and Unconventional Innate Immunity

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Incorporating Bortezomib into the Treatment of Lung Cancer

2007 • 78 citations

Oxidative Modifications of DAMPs Suppress Inflammation: The Case for S100A8 and S100A9

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Mechanisms of induction of apoptosis by anthraquinone anticancer drugs aclarubicin and mitoxantrone in comparison with doxorubicin: Relation to drug cytotoxicity and caspase-3 activation

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Increased expression of HMGB1 is associated with poor prognosis in human bladder cancer

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Involvement of Adenosine A2A Receptors in Engulfment-Dependent Apoptotic Cell Suppression of Inflammation

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Topoisomerase II Is Required for Mitoxantrone to Signal Nuclear Factor κB Activation in HL60 Cells

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Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury

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Differential expression proteomics of human colon cancer

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Hepatoma-derived Growth Factor Is a Neurotrophic Factor Harbored in the Nucleus

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Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

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Caspase-8 deficiency facilitates cellular transformation in vitro

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Nonheritable Cellular Variability Accelerates the Evolutionary Processes of Cancer

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Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma

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Effect of Ionizing Radiation on AP-1 Binding Activity and Basic Fibroblast Growth Factor Gene Expression in Drug-sensitive Human Breast Carcinoma MCF-7 and Multidrug-resistant MCF-7/ADR Cells

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Reactive Carbonyls Are a Major Th2-Inducing Damage-Associated Molecular Pattern Generated by Oxidative Stress

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Extracellular heat shock protein HSP90β secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-β1

2010 • 58 citations

Coxsackievirus B3 activates nuclear factor kappa B transcription factor via a phosphatidylinositol-3 kinase/protein kinase B-dependent pathway to improve host cell viability

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In Vitro Studies on Erythrosine-Based Photodynamic Therapy of Malignant and Pre-Malignant Oral Epithelial Cells

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Amplification of the γ-irradiation-induced cell death pathway by reactive oxygen species in human U937 cells

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Functional Analysis of Recombinant Calreticulin Fragment 39–272: Implications for Immunobiological Activities of Calreticulin in Health and Disease

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The chemotherapeutic drug oxaliplatin differentially affects blood DC function dependent on environmental cues

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T cells are crucial for the anti-metastatic effect of anti-epidermal growth factor receptor antibodies

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Shikonin inhibits tumor invasion via down‐regulation of NF‐κB‐mediated MMP‐9 expression in human ACC‐M cells

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Combined modalities of resistance in an oxaliplatin-resistant human gastric cancer cell line with enhanced sensitivity to 5-fluorouracil

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Loss-of-function alleles ofP2RX7andTLR4fail to affect the response to chemotherapy in non-small cell lung cancer

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Chemistry of St. John's Wort: Hypericin and Hyperforin

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The Role of the VPS4A-Exosome Pathway in the Intrinsic Egress Route of a DNA-Binding Anticancer Drug

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Clearance of dead cells: mechanisms, immune responses and implication in the development of diseases

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Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

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Shikonin Derivatives Protect Immune Organs from Damage and Promote Immune Responses In Vivo in Tumour‐bearing Mice

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Here, There Be Dragons: Charting Autophagy-Related Alterations in Human Tumors

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Hypericin photoactivation triggers down-regulation of matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells

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Extracellular BCL2 Proteins Are Danger-Associated Molecular Patterns That Reduce Tissue Damage in Murine Models of Ischemia-Reperfusion Injury

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Cytosolic superoxide dismutase activity after photodynamic therapy, intracellular distribution of Photofrin II and hypericin, and P-glycoprotein localization in human colon adenocarcinoma.

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Doxorubicin prevents endoplasmic reticulum stress-induced apoptosis

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The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure

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The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway

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Killing of Resistant Cancer Cells with Low Bak by a Combination of an Antimesothelin Immunotoxin and a TRAIL Receptor 2 Agonist Antibody

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MODULATION OF P-GLYCOPROTEIN EXPRESSION IN HYPERTHYROID RAT TISSUES

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Immunological studies of mitoxantrone in primary progressive MS

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The proteasome inhibitor bortezomib reverses P-glycoprotein-mediated leukemia multi-drug resistance through the NF-kappaB pathway.

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Indomethacin modulation of Adriamycin-induced effects on multiple cytolytic effector functions

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Molecular basis of the low activity of antitumor anthracenediones, mitoxantrone and ametantrone, in oxygen radical generation catalyzed by NADH dehydrogenase. Enzymatic and molecular modelling studies

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Role of Attraction and Danger Signals in the Uptake of Apoptotic and Necrotic Cells and its Immunological Outcome

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BAP31 is frequently overexpressed in patients with primary colorectal cancer and correlates with better prognosis

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Mitoxantrone as a Single Agent in Pretreated Metastatic Breast Cancer: Effects on T Lymphocyte Subsets and Their Relation to Clinical Response

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Immediate and short-, mid- and long-term effects of in vivo ionizing radiation exposure in BALB/c mice: I. Activation of lymphocytes and subpopulations.

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The tumor microenvironment: characterization, redox considerations and novel approaches for ROS-targeted gene therapy.

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Time trends of consumption and costs of drugs in a cancer referral centre

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