Cancer immunoediting by the innate immune system in the absence of adaptive immunity

Hallmarks of Cancer: The Next Generation

2011 • 58,651 citations

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

2006 • 24,853 citations

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

2011 • 5,649 citations

Monocyte and macrophage heterogeneity

2005 • 4,918 citations

The Immunobiology of Cancer Immunosurveillance and Immunoediting

2004 • 2,788 citations

The Three Es of Cancer Immunoediting

2004 • 2,781 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Alternative Activation of Macrophages: An Immunologic Functional Perspective

2008 • 2,611 citations

Distinct Role of Macrophages in Different Tumor Microenvironments

2006 • 2,130 citations

Natural Innate and Adaptive Immunity to Cancer

2011 • 1,878 citations

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

2009 • 1,517 citations

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

2011 • 1,515 citations

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

2009 • 1,405 citations

Adaptive immunity maintains occult cancer in an equilibrium state

2007 • 1,307 citations

Inflammation meets cancer, with NF-κB as the matchmaker

2011 • 1,298 citations

Macrophage polarization in tumour progression

2008 • 1,149 citations

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

2010 • 1,128 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Cancer Immunosurveillance and Immunoediting: The Roles of Immunity in Suppressing Tumor Development and Shaping Tumor Immunogenicity

2006 • 829 citations

Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells

2000 • 812 citations

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

2008 • 777 citations

New aspects of natural-killer-cell surveillance and therapy of cancer

2002 • 713 citations

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

2010 • 682 citations

Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice

2002 • 608 citations

A critical function for type I interferons in cancer immunoediting

2005 • 574 citations

Immune functions encoded by the natural killer gene complex

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Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

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Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis

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Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

Antigenicity of Murine Skin Tumors Induced by Ultraviolet Light2

1974 • 484 citations

Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

2002 • 447 citations

Oncogenic stress sensed by the immune system: role of natural killer cell receptors

2009 • 384 citations

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

2010 • 353 citations

A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas

2002 • 347 citations

NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma

2001 • 345 citations

NKG2D function protects the host from tumor initiation

2005 • 326 citations

DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors

2008 • 324 citations

Characterization of the Effects of Endotoxin on Macrophage Tumor Cell Killing

1978 • 298 citations

Accelerated tumor growth in mice deficient in DNAM-1 receptor

2008 • 260 citations

Innate Immune Surveillance of Spontaneous B Cell Lymphomas by Natural Killer Cells and γδ T Cells

2004 • 246 citations

Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon.

1983 • 236 citations

Control of Carcinogenesis: A Possible Role for the Activated Macrophage

1972 • 223 citations

Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma.

1983 • 177 citations

Resistance to Murine Tumors Conferred by Chronic Infection with Intracellular Protozoa, Toxoplasma gondii and Besnoitia jellisoni

1971 • 173 citations

Identification of a common gene signature for type II cytokine–associated myeloid cells elicited in vivo in different pathologic conditions

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Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model

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Rejection by syngeneic mice of cell variants obtained by mutagenesis of a malignant teratocarcinoma cell line.

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Activation of tumoricidal properties in human blood monocytes by liposomes containing lipophilic muramyl tripeptide.

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CD40 Ligation Activates Murine Macrophages via an IFN-γ-Dependent Mechanism Resulting in Tumor Cell Destruction In Vitro

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Peroxisome proliferator-activated receptor γ (PPARγ) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer

2006 • 106 citations

IFN-Dependent Down-Regulation of the NKG2D Ligand H60 on Tumors

2006 • 101 citations

Tumoristatic effects of anti‐CD40 mAb‐activated macrophages involve nitric oxide and tumour necrosis factor‐α

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CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumors

2008 • 37 citations

Cancer Immunoediting of the NK Group 2D Ligand H60a

2011 • 36 citations

Protective immunity to progressive tumors can be induced by antigen presented on regressor tumors.

1987 • 18 citations