CD73-Deficient Mice Are Resistant to Carcinogenesis

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

2001 • 1,261 citations

A2A adenosine receptor protects tumors from antitumor T cells

2006 • 923 citations

Extracellular adenosine triphosphate and adenosine in cancer

2010 • 531 citations

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

2010 • 530 citations

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

2011 • 483 citations

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

2007 • 468 citations

Anti–ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti–PD-1 or anti-CD137 mAb therapy

2011 • 450 citations

The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.

1997 • 419 citations

CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression

2010 • 394 citations

Adenosine receptors in regulation of dendritic cell differentiation and function

2008 • 384 citations

CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

2011 • 368 citations

Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates

2011 • 363 citations

Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

2008 • 295 citations

CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice

2011 • 244 citations

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors

2011 • 191 citations

A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments

2009 • 190 citations

Altered purinergic signaling in CD73‐deficient mice inhibits tumor progression

2011 • 137 citations

Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease

2012 • 86 citations

Combined affinity labelling and mass spectrometry analysis of differential cell surface protein expression in normal and prostate cancer cells

2005 • 46 citations

Modulators of Arginine Metabolism Do Not Impact on Peripheral T-Cell Tolerance and Disease Progression in a Model of Spontaneous Prostate Cancer

2011 • 28 citations