Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

2017 • 14,809 citations

Nivolumab plus Ipilimumab in Advanced Melanoma

2013 • 4,054 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

2011 • 1,934 citations

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

2008 • 1,560 citations

Up-Regulation of PD-L1, IDO, and T _regs in the Melanoma Tumor Microenvironment Is Driven by CD8 ⁺ T Cells

2013 • 1,513 citations

mTOR regulates memory CD8 T-cell differentiation

2009 • 1,473 citations

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

2009 • 1,425 citations

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

2009 • 1,347 citations

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8 ⁺ T Cells

2004 • 544 citations

Enhanced Antitumor Activity of Murine-Human Hybrid T-Cell Receptor (TCR) in Human Lymphocytes Is Associated with Improved Pairing and TCR/CD3 Stability

2006 • 437 citations

Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation

2006 • 436 citations

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

2010 • 421 citations

The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells

1990 • 353 citations

Facilitating matched pairing and expression of TCR chains introduced into human T cells

2006 • 352 citations

Interleukin-15 biology and its therapeutic implications in cancer

2011 • 335 citations

Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes

2006 • 315 citations

Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation

2012 • 267 citations

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

2009 • 243 citations

Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool

2005 • 224 citations

Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool

2005 • 212 citations

Antigen-specific human T-cell responses and T cell–dependent production of human antibodies in a humanized mouse model

2008 • 121 citations

A Model for Personalized in Vivo Analysis of Human Immune Responsiveness

2012 • 118 citations

Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells

2005 • 110 citations

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

2011 • 97 citations

Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism

2004 • 97 citations

Regulating Mammalian Target of Rapamycin To Tune Vaccination-Induced CD8+ T Cell Responses for Tumor Immunity

2012 • 82 citations

MHC class I-restricted recognition of a melanoma antigen by a human CD4+ tumor infiltrating lymphocyte.

1999 • 82 citations

Immunotherapy for Melanoma: Current Status and Perspectives

2010 • 79 citations

Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase

2010 • 79 citations

Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells

2002 • 58 citations

Human MHC Class I-restricted high avidity CD4⁺T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo

2012 • 47 citations

Redirecting human CD4+ T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR αβ gene transfer requires CD8α

2004 • 45 citations

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

2011 • 42 citations

Characterization of MHC class-I restricted TCRαβ+ CD4− CD8− double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination

2008 • 38 citations

MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

2012 • 23 citations