Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

2017 • 14,809 citations

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

The blockade of immune checkpoints in cancer immunotherapy

2012 • 12,062 citations

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

2012 • 11,574 citations

Cancer-related inflammation

2008 • 10,288 citations

Immunity, Inflammation, and Cancer

2010 • 9,544 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

2010 • 4,335 citations

Nivolumab plus Ipilimumab in Advanced Melanoma

2013 • 4,054 citations

T cell exhaustion

2011 • 3,396 citations

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

2013 • 3,290 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Batf3 Deficiency Reveals a Critical Role for CD8α ⁺ Dendritic Cells in Cytotoxic T Cell Immunity

2008 • 1,781 citations

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

2010 • 1,711 citations

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

2014 • 1,549 citations

Selected reaction monitoring for quantitative proteomics: a tutorial

2008 • 1,352 citations

Adaptive immunity maintains occult cancer in an equilibrium state

2007 • 1,307 citations

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

2012 • 1,160 citations

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

2013 • 1,019 citations

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

2013 • 1,016 citations

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

2013 • 848 citations

Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma

2013 • 777 citations

NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8–11

2008 • 768 citations

Exploiting the Mutanome for Tumor Vaccination

2012 • 762 citations

NetMHCpan, a method for MHC class I binding prediction beyond humans

2008 • 726 citations

Options and considerations when selecting a quantitative proteomics strategy

2010 • 583 citations

Using i<scp>RT</scp>, a normalized retention time for more targeted measurement of peptides

2012 • 566 citations

Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method

2005 • 502 citations

Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts

2012 • 479 citations

The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage

2005 • 448 citations

CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation

1999 • 412 citations

Design and use of conditional MHC class I ligands

2006 • 331 citations

Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication

2011 • 262 citations

Bystander elimination of antigen loss variants in established tumors

2004 • 259 citations

HLA Class I Alleles Are Associated with Peptide-Binding Repertoires of Different Size, Affinity, and Immunogenicity

2013 • 254 citations

Antigen Bias in T Cell Cross-Priming

2004 • 184 citations

HLA-Binding Properties of Tumor Neoepitopes in Humans

2014 • 177 citations

TIL therapy broadens the tumor-reactive CD8⁺T cell compartment in melanoma patients

2012 • 164 citations

Antigen Spreading Contributes to MAGE Vaccination-Induced Regression of Melanoma Metastases

2011 • 162 citations

Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load

2011 • 141 citations

RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.

1992 • 132 citations

Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers

2012 • 123 citations

Biochemical Large-Scale Identification of MHC Class I Ligands

2012 • 75 citations

Two Preferentially Expressed Proteins Protect Vascular Endothelial Cells from an Attack by Peptide-Specific CTL

2012 • 12 citations