The Platelet Glycoprotein Ib-IX-V Complex

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions

2002 • 835 citations

Platelet Glycoprotein Ibα Is a Counterreceptor for the Leukocyte Integrin Mac-1 (Cd11b/Cd18)

2000 • 559 citations

Bernard-Soulier Syndrome

1998 • 552 citations

Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain

2002 • 550 citations

Ristocetin - A New Tool in the Investigation of Platelet Aggregation

1971 • 453 citations

The leucine-rich repeat structure

2008 • 435 citations

Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.

1987 • 376 citations

Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate--dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.

1978 • 368 citations

The platelet glycoprotein Ib???IX complex

1994 • 259 citations

Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation

1992 • 256 citations

Controlled shedding of platelet glycoprotein (GP)VI and GPIb–IX–V by ADAM family metalloproteinases

2007 • 250 citations

Binding of Thrombin to Glycoprotein Ib Accelerates the Hydrolysis of Par-1 on Intact Platelets

2001 • 228 citations

Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation

1992 • 218 citations

Platelet glycocalicin. Interaction with thrombin and role as thrombin receptor of the platelet surface.

1978 • 209 citations

Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane.

1992 • 203 citations

Crystal Structure of the Wild-type von Willebrand Factor A1-Glycoprotein Ibα Complex Reveals Conformation Differences with a Complex Bearing von Willebrand Disease Mutations

2004 • 192 citations

Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane

1987 • 191 citations

Efficient plasma membrane expression of a functional platelet glycoprotein Ib-IX complex requires the presence of its three subunits.

1992 • 191 citations

Signaling through GP Ib-IX-V activates αIIbβ3 independently of other receptors

2004 • 188 citations

Modulation of α-Thrombin Function by Distinct Interactions with Platelet Glycoprotein Ibα

2003 • 187 citations

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

2012 • 185 citations

Mocarhagin, a Novel Cobra Venom Metalloproteinase, Cleaves the Platelet von Willebrand Factor Receptor Glycoprotein Ibα. Identification of the Sulfated Tyrosine/Anionic Sequence Tyr-276−Glu-282 of Glycoprotein Ibα as a Binding Site for von Willebrand Factor and α-Thrombin

1996 • 185 citations

Reduced thrombin binding and aggregation in Bernard-Soulier platelets.

1978 • 176 citations

Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibα mechanoreceptor

2002 • 174 citations

Interactions of Platelets with Subendothelium and Endothelium

2005 • 171 citations

Platelet plasma membrane glycoproteins Identification of a proteolytic substrate for thrombin

1977 • 170 citations

Crystal Structure of the Platelet Glycoprotein Ibα N-terminal Domain Reveals an Unmasking Mechanism for Receptor Activation

2002 • 168 citations

A thrombin receptor function for platelet glycoprotein Ib–IX unmasked by cleavage of glycoprotein V

2001 • 168 citations

Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex

1989 • 167 citations

The structure of the GPIb–filamin A complex

2005 • 160 citations

Glycoprotein Ib-V-IX, a Receptor for von Willebrand Factor, Couples Physically and Functionally to the Fc Receptor γ-Chain, Fyn, and Lyn to Activate Human Platelets

1999 • 159 citations

Crystal Structure of the GpIbα-Thrombin Complex Essential for Platelet Aggregation

2003 • 153 citations

Localization of the Adhesion Receptor Glycoprotein Ib-IX-V Complex to Lipid Rafts Is Required for Platelet Adhesion and Activation

2002 • 151 citations

The organizing principle of the platelet glycoprotein Ib–IX–V complex

2013 • 149 citations

Physical Proximity and Functional Interplay of the Glycoprotein Ib-IX-V Complex and the Fc Receptor FcγRIIA on the Platelet Plasma Membrane

1998 • 149 citations

Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications.

1992 • 148 citations

Platelet glycocalicin. II. Purification and characterization.

1976 • 145 citations

Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation.

1993 • 145 citations

Expression of Platelet Glycoprotein (GP) V in Heterologous Cells and Evidence for Its Association with GP Ibα in Forming a GP Ib-IX-V Complex on the Cell Surface

1995 • 144 citations

Identification of a Binding Sequence for the 14-3-3 Protein within the Cytoplasmic Domain of the Adhesion Receptor, Platelet Glycoprotein Ibα

1996 • 142 citations

Signalling through the platelet glycoprotein Ib-V–IX complex

2004 • 139 citations

Purification and preliminary physicochemical characterization of human platelet membrane glycoprotein V.

1981 • 137 citations

Spectrum of the Mutations in Bernard-Soulier Syndrome

2014 • 134 citations

Binding of Purified 14-3-3 ζ Signaling Protein to Discrete Amino Acid Sequences within the Cytoplasmic Domain of the Platelet Membrane Glycoprotein Ib-IX-V Complex

1998 • 134 citations

The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets.

1986 • 129 citations

Requirement of leucine-rich repeats of glycoprotein (GP) Ibα for shear-dependent and static binding of von Willebrand factor to the platelet membrane GP Ib–IX-V complex

2000 • 127 citations

Role of Fc receptor γ-chain in platelet glycoprotein Ib–mediated signaling

2001 • 126 citations

Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor

1989 • 124 citations

VWF excess and ADAMTS13 deficiency: a unifying pathomechanism linking inflammation to thrombosis in DIC, malaria, and TTP

2014 • 121 citations

Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3ζ

2000 • 116 citations

Identification of a region in the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX complex that binds to purified actin-binding protein.

1992 • 114 citations

Glycoprotein Ibα forms disulfide bonds with 2 glycoprotein Ibβ subunits in the resting platelet

2006 • 114 citations

Targeting Platelet–Leukocyte Interactions

2003 • 114 citations

A critical role for 14-3-3ζ protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications

2005 • 108 citations

Identification of aspartic acid 514 through glutamic acid 542 as a glycoprotein Ib-IX complex receptor recognition sequence in von Willebrand factor. Mechanism of modulation of von Willebrand factor by ristocetin and botrocetin

1992 • 107 citations

Interaction of calmodulin with the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex

2001 • 101 citations

Tyrosine Sulfation of the Glycoprotein Ib-IX Complex: Identification of Sulfated Residues and Effect on Ligand Binding

1994 • 101 citations

The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation

2005 • 100 citations

Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex

2014 • 100 citations

Glycoprotein V-Deficient Platelets Have Undiminished Thrombin Responsiveness and Do Not Exhibit a Bernard-Soulier Phenotype

1999 • 98 citations

Clinical and laboratory features of 103 patients from 42 Italian families with inherited thrombocytopenia derived from the monoallelic Ala156Val mutation of GPIb (Bolzano mutation)

2011 • 95 citations

Glycoprotein (GP) Ib beta is the critical subunit linking GP Ib alpha and GP IX in the GP Ib-IX complex. Analysis of partial complexes.

1994 • 93 citations

Bernard-Soulier Syndrome: An Update

2013 • 91 citations

Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease

2005 • 84 citations

Subcellular distribution of the different platelet proteins phosphorylated on exposure of intact platelets to ionophore A23187 or to prostaglandin E1. Possible role of a membrane phosphopolypeptide in the regulation of calcium-ion transport

1979 • 83 citations

The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145

1995 • 83 citations

Filamin A binding to the cytoplasmic tail of glycoprotein Ibα regulates von Willebrand factor–induced platelet activation

2003 • 83 citations

Activation of Human Platelets by Misfolded Proteins

2007 • 82 citations

Action of thrombin on surface glycoproteins of human platelets

1979 • 82 citations

Mac-1 (CD11b/CD18) Links Inflammation and Thrombosis After Glomerular Injury

2009 • 82 citations

Platelet glycoprotein Ibβ is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase

1989 • 81 citations

Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation

2016 • 79 citations

Human Signaling Protein 14-3-3ζ Interacts With Platelet Glycoprotein Ib Subunits Ibα and Ibβ

1998 • 78 citations

Sustained elevated amounts of circulating procoagulant membrane microparticles and soluble GPV after acute myocardial infarction in diabetes mellitus

2004 • 78 citations

Interaction between Platelet Glycoprotein Ibα and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear

2002 • 78 citations

Structure-function relationships in the interaction of alpha-thrombin with blood platelets.

1977 • 77 citations

Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane glycoprotein Ib.

1990 • 76 citations

Increased thrombogenesis and embolus formation in mice lacking glycoprotein V

2001 • 75 citations

Regulation of Glycoprotein Ib-IX-von Willebrand Factor Interaction by cAMP-dependent Protein Kinase-mediated Phosphorylation at Ser 166 of Glycoprotein Ibβ

2002 • 75 citations

Platelet Activation by von Willebrand Factor Requires Coordinated Signaling through Thromboxane A2 and FcγIIA Receptor

2001 • 74 citations

Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals

2016 • 74 citations

Receptors, rafts, and microvesicles in thrombosis and inflammation

2005 • 71 citations

Characterization of the Initial α-Thrombin Interaction with Glycoprotein Ibα in Relation to Platelet Activation

1998 • 70 citations

Evidence for a single class of thrombin-binding sites on human platelets

1976 • 70 citations

Cytoplasmic domains of GpIbα and GpIbβ regulate 14-3-3ζ binding to GpIb/IX/V

2000 • 69 citations

Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb‐IX‐V, and CLEC‐2

2013 • 69 citations

The Cytoplasmic Domain of the Platelet Glycoprotein Ibα Is Phosphorylated at Serine 609

1999 • 68 citations

TNF receptor‐associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets

2010 • 67 citations

Action of thrombin on surface glycoproteins of human platelets

1979 • 66 citations

Molecular Force Spectroscopy on Cells

2015 • 65 citations

Ristocetin and Botrocetin Involve Two Distinct Domains of von Willebrand Factor for Binding to Platelet Membrane Glycoprotein lb

1990 • 64 citations

Aspirin Induces Platelet Receptor Shedding via ADAM17 (TACE)

2005 • 64 citations

The platelet glycoprotein Ib–von Willebrand factor interaction activates the collagen receptor α2β1 to bind collagen: activation-dependent conformational change of the α2-I domain

2004 • 62 citations

Glycoprotein Ib-IX-V Complex Transmits Cytoskeletal Forces That Enhance Platelet Adhesion

2016 • 62 citations

Synthesis, Assembly, and Intracellular Transport of the Platelet Glycoprotein Ib-IX-V Complex

1998 • 62 citations

The perturbation of thrombin binding to human platelets by anions.

1975 • 53 citations

Novel point mutation in a leucine-rich repeat of the GPIb chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome affecting two unrelated families: the N41H variant

2008 • 53 citations

Identification of a novel 14-3-3ζ binding site within the cytoplasmic tail of platelet glycoprotein Ibα

2004 • 52 citations

Monoclonal antibody to glycoprotein Ib inhibits both thrombinand ristocetin-induced platelet aggregations

1985 • 52 citations

GPIbα-selective activation of platelets induces platelet signaling events comparable to GPVI activation events

2010 • 51 citations

The Cytoplasmic Domain of Glycoprotein (GP) Ibα Constrains the Lateral Diffusion of the GP Ib−IX Complex and Modulates von Willebrand Factor Binding

1997 • 49 citations

A functional 14-3-3ζ–independent association of PI3-kinase with glycoprotein Ibα, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

2008 • 48 citations

Glycoprotein Ib and glycoprotein IX in human platelets are acylated with palmitic acid through thioester linkages

1989 • 48 citations

Binding of α-thrombin to surface-anchored platelet glycoprotein Ibα sulfotyrosines through a two-site mechanism involving exosite I

2011 • 45 citations

Measurement of GPV Released by Activated Platelets Using a Sensitive Immunocapture ELISA – Its Use to Follow Platelet Storage in Transfusion

1999 • 45 citations

Characterization of an antiglycoprotein Ib monoclonal antibody that specifically inhibits platelet-thrombin interaction

1991 • 44 citations

A Role for von Willebrand Factor Proline Residues 702-704 in Ristocetin-Mediated Binding to Platelet Glycoprotein Ib

1993 • 43 citations

GPV Is a Marker of In Vivo Platelet Activation – Study in a Rat Thrombosis Model

2000 • 42 citations

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibα

2005 • 41 citations

Gene Cloning of Rat and Mouse Platelet Glycoprotein V: Identification of Megakaryocyte-Specific Promoters and Demonstration of Functional Thrombin Cleavage

1997 • 39 citations

The Transmembrane Domain of Glycoprotein Ibβ Is Critical to Efficient Expression of Glycoprotein Ib-IX Complex in the Plasma Membrane

2006 • 38 citations

Identification of a Novel 14-3-3ζ Binding Site Within the Cytoplasmic Domain of Platelet Glycoprotein Ibα That Plays a Key Role in Regulating the von Willebrand Factor Binding Function of Glycoprotein Ib-IX

2009 • 37 citations

Mechanochemistry of receptor–ligand bonds

2009 • 33 citations

Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib–IX complex

2007 • 33 citations

Specific Heteromeric Association of Four Transmembrane Peptides Derived from Platelet Glycoprotein Ib–IX Complex

2008 • 30 citations

Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib‐IX complex

2012 • 26 citations

Platelet Endothelial Cell Adhesion Molecule-1 Inhibits Platelet Response to Thrombin and von Willebrand Factor by Regulating the Internalization of Glycoprotein Ib via AKT/Glycogen Synthase Kinase-3/Dynamin and Integrin αIIbβ3

2014 • 25 citations

The platelet glycoprotein Ib‐IX‐V complex anchors lipid rafts to the membrane skeleton: implications for activation‐dependent cytoskeletal translocation of signaling molecules

2009 • 21 citations

Transmembrane and Trans-subunit Regulation of Ectodomain Shedding of Platelet Glycoprotein Ibα

2010 • 21 citations

A role for glycosphingolipid‐enriched microdomains in platelet glycoprotein Ib‐mediated platelet activation

2007 • 18 citations

Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′‐cyclic adenosine monophosphate‐signaling pathway

2015 • 18 citations

A novel mutation in GP1BA gene leads to mono-allelic Bernard Soulier syndrome form of macrothrombocytopenia

2016 • 14 citations

The α1 helix-β13 strand spanning Leu214 to Val229 of platelet glycoprotein Ibα facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1

2004 • 7 citations

Role of 14-3-3ζ in Platelet Glycoprotein Ibα-von Willebrand Factor Interaction-Induced Signaling

2012 • 7 citations

The Transmembrane Domains of β and IX Subunits Mediate the Localization of the Platelet Glycoprotein Ib-IX Complex to the Glycosphingolipid-enriched Membrane Domain

2015 • 4 citations

Further studies on the interaction between human platelet membrane glycoproteins IIb and IIIa in triton X-100

1982 • 4 citations

The mysteries of a platelet adhesion receptor

2005 • 4 citations