Glycoprotein V-Deficient Platelets Have Undiminished Thrombin Responsiveness and Do Not Exhibit a Bernard-Soulier Phenotype

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1988 • 7,584 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor

1996 • 1,178 citations

A dual thrombin receptor system for platelet activation

1998 • 972 citations

Protease-activated receptor 3 is a second thrombin receptor in humans

1997 • 878 citations

Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow

1998 • 809 citations

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

1999 • 802 citations

Defective platelet activation in Gαq-deficient mice

1997 • 566 citations

A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis

1998 • 512 citations

Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresis.

1977 • 451 citations

Specific roles for platelet surface glycoproteins in platelet function

1975 • 411 citations

Decreased adhesion of platelets to subendothelium in von Willebrand's disease.

1974 • 391 citations

Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.

1987 • 376 citations

Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets

1999 • 359 citations

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals

1996 • 266 citations

The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence.

1988 • 254 citations

Characterization of the platelet membrane glycoprotein abnormalities in Bernard-Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis.

1982 • 245 citations

The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments.

1986 • 238 citations

Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membrane

1985 • 229 citations

Platelet glycocalicin. Interaction with thrombin and role as thrombin receptor of the platelet surface.

1978 • 209 citations

Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane.

1992 • 203 citations

Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.

1992 • 185 citations

Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding.

1990 • 182 citations

Bleeding Time in Rats: A Comparison of Different Experimental Conditions

1982 • 177 citations

Reduced thrombin binding and aggregation in Bernard-Soulier platelets.

1978 • 176 citations

Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib.

1985 • 173 citations

Platelet plasma membrane glycoproteins Identification of a proteolytic substrate for thrombin

1977 • 170 citations

The hemostatic plug.

1977 • 169 citations

Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures.

1989 • 167 citations

Analysis of the glycoprotein and protein composition of Bernard-Soulier platelets by single and two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

1981 • 151 citations

Eccentric localization of von Willebrand factor in an internal structure of platelet alpha-granule resembling that of Weibel-Palade bodies

1985 • 150 citations

Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation.

1993 • 145 citations

Expression of Platelet Glycoprotein (GP) V in Heterologous Cells and Evidence for Its Association with GP Ibα in Forming a GP Ib-IX-V Complex on the Cell Surface

1995 • 144 citations

Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease

1992 • 144 citations

Structure and function of platelet membrane glycoproteins Ib and V

1985 • 143 citations

Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor

1989 • 124 citations

Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome.

1993 • 114 citations

The interaction of the von Willebrand factor-A1 domain with platelet glycoprotein Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein.

1993 • 114 citations

Thrombin Receptors on Human Platelets

1997 • 109 citations

Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome

1993 • 106 citations

Site-directed mutagenesis of a soluble recombinant fragment of platelet glycoprotein Ib alpha demonstrating negatively charged residues involved in von Willebrand factor binding

1991 • 104 citations

Ultrastructural localization of human platelet thrombospondin, fibrinogen, fibronectin, and von Willebrand factor in frozen thin section

1985 • 103 citations

Gene defects in 150 unrelated French cases with type 2 von Willebrand disease: from the patient to the gene. INSERM Network on Molecular Abnormalities in von Willebrand Disease.

1997 • 100 citations

Gene Defects in 150 Unrelated French Cases with Type 2 von Willebrand Disease: from the Patient to the Gene

1997 • 84 citations

Action of thrombin on surface glycoproteins of human platelets

1979 • 82 citations

Glycoprotein (GP) Ib-IX-transfected Cells Roll on a von Willebrand Factor Matrix under Flow

1999 • 82 citations

Type 2M von Willebrand Disease: F606I and I662F Mutations in the Glycoprotein Ib Binding Domain Selectively Impair Ristocetin- but not Botrocetin-Mediated Binding of von Willebrand Factor to Platelets

1998 • 80 citations

Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins.

1993 • 79 citations

Correlation of thrombin-induced glycoprotein V hydrolysis and platelet activation.

1983 • 75 citations

Antibodies to Protease-Activated Receptor 3 Inhibit Activation of Mouse Platelets by Thrombin

1998 • 73 citations

Action of thrombin on surface glycoproteins of human platelets

1979 • 66 citations

Glycoprotein V is not the thrombin activation receptor on human blood platelets

1986 • 62 citations

Venom coagglutinin for detection of von Willebrand factor activity in animal plasmas.

1983 • 61 citations

Human Endothelial Cells in Culture and In Vivo Express on Their Surface All Four Components of the Glycoprotein Ib/IX/V Complex

1997 • 59 citations

Bernard‐Soulier syndrome: quantitative characterization of megakaryocytes and platelets by flow cytometric and platelet kinetic measurements

1994 • 57 citations

Optimal techniques for the immunocytochemical demonstration of?-thromboglobulin, platelet factor 4, and fibrinogen in the alpha granules of unstimulated platelets

1984 • 51 citations

Measurement of GPV Released by Activated Platelets Using a Sensitive Immunocapture ELISA – Its Use to Follow Platelet Storage in Transfusion

1999 • 45 citations

Human platelet glycoprotein V: its role in enhancing expression of the glycoprotein Ib receptor

1995 • 41 citations

Cloning of the Murine Platelet Glycoprotein Ibα Gene Highlighting Species-Specific Platelet Adhesion

1997 • 40 citations

Expression and characterization of functionally active fragments of the platelet glycoprotein (GP) Ib-IX complex in mammalian cells. Incorporation of GP Ib alpha into the cell surface membrane.

1993 • 40 citations

Gene Cloning of Rat and Mouse Platelet Glycoprotein V: Identification of Megakaryocyte-Specific Promoters and Demonstration of Functional Thrombin Cleavage

1997 • 39 citations

Interaction of Platelet Glycoprotein V with Glycoprotein Ib-IX Regulates Expression of the Glycoproteins and Binding of von Willebrand Factor to Glycoprotein Ib-IX in Transfected Cells

1995 • 37 citations

Overview Article: Biostructure of Blood Platelets

1980 • 35 citations

Ultrastructure of platelets in Bernard-Soulier syndrome.

1975 • 28 citations

Botrocetin agglutination of rat megakaryocytes: a rapid method for megakaryocyte isolation.

1992 • 7 citations