Crystal Structure of the GpIbα-Thrombin Complex Essential for Platelet Aggregation

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Thrombin signalling and protease-activated receptors

2000 • 2,383 citations

Platelets in atherothrombosis

2002 • 1,533 citations

Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor

1996 • 1,178 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

1990 • 718 citations

Platelets and Thrombin Generation

2002 • 652 citations

Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain

2002 • 550 citations

Specific roles for platelet surface glycoproteins in platelet function

1975 • 411 citations

The Vascular Biology of the Glycoprotein Ib-IX-V Complex

2001 • 281 citations

Crystal Structure of the von Willebrand Factor A1 Domain and Implications for the Binding of Platelet Glycoprotein Ib

1998 • 255 citations

Platelet glycocalicin. Interaction with thrombin and role as thrombin receptor of the platelet surface.

1978 • 209 citations

Molecular mechanisms of platelet adhesion and activation

1997 • 201 citations

Mocarhagin, a Novel Cobra Venom Metalloproteinase, Cleaves the Platelet von Willebrand Factor Receptor Glycoprotein Ibα. Identification of the Sulfated Tyrosine/Anionic Sequence Tyr-276−Glu-282 of Glycoprotein Ibα as a Binding Site for von Willebrand Factor and α-Thrombin

1996 • 185 citations

The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity

2000 • 177 citations

A thrombin receptor function for platelet glycoprotein Ib–IX unmasked by cleavage of glycoprotein V

2001 • 168 citations

Crystal Structure of the Platelet Glycoprotein Ibα N-terminal Domain Reveals an Unmasking Mechanism for Receptor Activation

2002 • 168 citations

Unique Pathway of Thrombin-induced Platelet Aggregation Mediated by Glycoprotein Ib

2001 • 164 citations

Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha.

1994 • 155 citations

Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin.

1991 • 137 citations

The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets.

1986 • 129 citations

The Glycoprotein Ib-IX-V Complex in Platelet Adhesion and Signaling

1999 • 128 citations

Identification of Three Tyrosine Residues of Glycoprotein Ibα with Distinct Roles in von Willebrand Factor and α-Thrombin Binding

1995 • 120 citations

Von Willebrand factor

2003 • 117 citations

Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III.

1994 • 104 citations

Tyrosine Sulfation of the Glycoprotein Ib-IX Complex: Identification of Sulfated Residues and Effect on Ligand Binding

1994 • 101 citations

Localization of von Willebrand Factor and Thrombin-Interactive Domains on Human Platelet Glycoprotein Ib

1990 • 98 citations

Structure-function relationships in the interaction of alpha-thrombin with blood platelets.

1977 • 77 citations

Protein recognition by cell surface receptors: physiological receptors versus virus interactions

2002 • 71 citations

Platelet Glycoprotein Ibα Binds to Thrombin Anion-binding Exosite II Inducing Allosteric Changes in the Activity of Thrombin

2001 • 61 citations

The Asp272–Glu282 Region of Platelet Glycoprotein Ibα Interacts with the Heparin-binding Site of α-Thrombin and Protects the Enzyme from the Heparin-catalyzed Inhibition by Antithrombin III

2000 • 61 citations

High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domains.

1994 • 58 citations

Structural and Functional Mapping of the Thrombin Domain Involved in the Binding to the Platelet Glycoprotein Ib

2001 • 50 citations

Thrombin interaction with platelet glycoprotein Ib: effect of glycocalicin on thrombin specificity

1992 • 46 citations

GPV Is a Marker of In Vivo Platelet Activation – Study in a Rat Thrombosis Model

2000 • 42 citations

Thrombin Interaction with Platelet GPIB: Role of the Heparin Binding Domain

1997 • 32 citations

Effect of the Hirudin Carboxy-Terminal Peptide 54-65 on the Interaction of Thrombin with Platelets

1991 • 31 citations

Binding of human α-thrombin to platelet GpIb: energetics and functional effects

1998 • 17 citations

Characteristics of the Interaction between Thrombin Exosite1 and the Sequence 269-297 of Platelet Glycoprotein Ibα

1998 • 14 citations

Thrombin Binding to Platelet Membrane Glycoprotein Ib

1992 • 8 citations