A critical role for 14-3-3ζ protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications

14-3-3 Proteins: Structure, Function, and Regulation

2000 • 1,552 citations

Platelets in atherothrombosis

2002 • 1,533 citations

Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor

1996 • 1,178 citations

Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.

1987 • 376 citations

von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.

1991 • 280 citations

The Platelet Glycoprotein Ib-IX-V Complex

2017 • 269 citations

A Stimulatory Role for cGMP-Dependent Protein Kinase in Platelet Activation

2003 • 265 citations

The platelet glycoprotein Ib???IX complex

1994 • 259 citations

The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence.

1988 • 254 citations

Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membrane

1985 • 229 citations

Glycoprotein Ib-V-IX, a Receptor for von Willebrand Factor, Couples Physically and Functionally to the Fc Receptor γ-Chain, Fyn, and Lyn to Activate Human Platelets

1999 • 159 citations

Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation.

1985 • 150 citations

A murine antiglycoprotein Ib complex monoclonal antibody, SZ 2, inhibits platelet aggregation induced by both ristocetin and collagen

1987 • 146 citations

Identification of a Binding Sequence for the 14-3-3 Protein within the Cytoplasmic Domain of the Adhesion Receptor, Platelet Glycoprotein Ibα

1996 • 142 citations

Binding of Purified 14-3-3 ζ Signaling Protein to Discrete Amino Acid Sequences within the Cytoplasmic Domain of the Platelet Membrane Glycoprotein Ib-IX-V Complex

1998 • 134 citations

Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets.

1994 • 133 citations

Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX–Mediated Activation of Integrin αIIbβ3 Using a Reconstituted Mammalian Cell Expression Model

1999 • 132 citations

A Mitogen-activated Protein Kinase-dependent Signaling Pathway in the Activation of Platelet Integrin αIIbβ3

2001 • 121 citations

Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3ζ

2000 • 116 citations

Identification of a region in the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX complex that binds to purified actin-binding protein.

1992 • 114 citations

Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex

1994 • 112 citations

Interaction of calmodulin with the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex

2001 • 101 citations

Asialo von Willebrand factor interactions with platelets. Interdependence of glycoproteins Ib and IIb/IIIa for binding and aggregation.

1985 • 93 citations

Lateral Clustering of Platelet GP Ib-IX Complexes Leads to Up-regulation of the Adhesive Function of Integrin αIIbβ3

2002 • 86 citations

Signaling across the Platelet Adhesion Receptor Glycoprotein Ib-IX Induces αIIbβ3 Activation Both in Platelets and a Transfected Chinese Hamster Ovary Cell System

2000 • 85 citations

Glycoprotein Ib-von Willebrand Factor Interactions Activate Tyrosine Kinases in Human Platelets

1997 • 85 citations

Filamin A binding to the cytoplasmic tail of glycoprotein Ibα regulates von Willebrand factor–induced platelet activation

2003 • 83 citations

Platelet glycoprotein Ibβ is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase

1989 • 81 citations

Regulation of von Willebrand Factor Binding to the Platelet Glycoprotein Ib-IX by a Membrane Skeleton-dependent Inside-out Signal

2001 • 79 citations

Human Signaling Protein 14-3-3ζ Interacts With Platelet Glycoprotein Ib Subunits Ibα and Ibβ

1998 • 78 citations

Interaction between Platelet Glycoprotein Ibα and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear

2002 • 78 citations

Regulation of Glycoprotein Ib-IX-von Willebrand Factor Interaction by cAMP-dependent Protein Kinase-mediated Phosphorylation at Ser 166 of Glycoprotein Ibβ

2002 • 75 citations

Thrombotic Thrombocytopenic Purpura: The Systemic Clumping “Plague”

2002 • 70 citations

Cytoplasmic domains of GpIbα and GpIbβ regulate 14-3-3ζ binding to GpIb/IX/V

2000 • 69 citations

Identification of glycoprotein Ib beta as one of the major proteins phosphorylated during exposure of intact platelets to agents that activate cyclic AMP-dependent protein kinase.

1987 • 68 citations

14-3-3ζ Mediates Integrin-induced Activation of Cdc42 and Rac

2003 • 68 citations

Glycoprotein Ib-von Willebrand Factor Interactions Activate Tyrosine Kinases in Human Platelets

1997 • 68 citations

The Cytoplasmic Domain of the Platelet Glycoprotein Ibα Is Phosphorylated at Serine 609

1999 • 68 citations

Molecular Analyses of the Platelet Glycoprotein Ib-IX-V Receptor

1998 • 57 citations

A Novel Ligand-binding Site in the ζ-Form 14-3-3 Protein Recognizing the Platelet Glycoprotein Ibα and Distinct from the c-Raf-binding Site

1998 • 56 citations

Identification of a novel 14-3-3ζ binding site within the cytoplasmic tail of platelet glycoprotein Ibα

2004 • 52 citations

The Cytoplasmic Domain of Glycoprotein (GP) Ibα Constrains the Lateral Diffusion of the GP Ib−IX Complex and Modulates von Willebrand Factor Binding

1997 • 49 citations

Inhibition of von Willebrand factor-dependent platelet function by increased platelet cyclic AMP and its prevention by cytoskeleton- disrupting agents

1981 • 35 citations

Flow chambers and their standardization for use in studies of thrombosis. On behalf of the Subcommittee on Rheology of the Scientific and Standardization Committee of the ISTH.

1994 • 34 citations

Cytoplasmic Truncation of Glycoprotein Ibα Weakens Its Interaction with von Willebrand Factor and Impairs Cell Adhesion

2003 • 28 citations

Flow Chambers and their Standardization for Use in Studies of Thrombosis

1994 • 28 citations

[Studies on monoclonal antibodies to human von Willebrand factor].

1986 • 14 citations

Structure-function relationships of platelet glycoprotein Ib as a receptor for von Willebrand factor.

1986 • 2 citations