The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3′-Kinase

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.

1984 • 455 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.

1991 • 422 citations

The alphas, betas, and kinases of cytokine receptor complexes

1993 • 418 citations

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

1993 • 395 citations

Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice

1993 • 369 citations

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

1991 • 349 citations

The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells.

1991 • 335 citations

Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events.

1993 • 312 citations

Cell Surface Molecules and Early Events Involved in Human T Lymphocyte Activation

1987 • 297 citations

Human Ig superfamily CTLA‐4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA‐4 cytoplasmic domains

1988 • 296 citations

Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form

1990 • 224 citations

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

1993 • 178 citations

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.

1987 • 174 citations

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.

1992 • 173 citations

Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells.

1986 • 165 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Role of Lymphokine and Antigen in the Control of Specific T Cell Responses

1980 • 147 citations

The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.

1990 • 141 citations

The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.

1992 • 125 citations

Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

1993 • 121 citations

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.

1992 • 118 citations

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.

1992 • 103 citations

CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway.

1992 • 92 citations

Closing in on SH2 specificity

1993 • 86 citations

Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation

1993 • 84 citations

T90/44 (9.3 antigen). A cell surface molecule with a function in human T cell activation

1986 • 60 citations

Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3.

1991 • 31 citations