The Molecular Basis of Thymocyte Positive Selection and CD4/CD8 Lineage Commitment

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

Notch Signaling

1995 • 1,282 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

1995 • 702 citations

Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.

1992 • 667 citations

Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity.

1995 • 594 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.

1995 • 517 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2

1996 • 459 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Activation events during thymic selection.

1992 • 326 citations

Mammalian hairy and Enhancer of Split Homolog 1 Regulates Differentiation of Retinal Neurons and Is Essential for Eye Morphogenesis

1996 • 322 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.

1996 • 210 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1993 • 201 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Thymus Independent T Cell Development and Selection in the Intestinal Epithelium

1994 • 197 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jκ or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jκ and Activate Transcription

1997 • 176 citations

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.

1993 • 173 citations

Dominant interfering alleles define a role for c-Myb in T-cell development.

1994 • 172 citations

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

1993 • 156 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes.

1994 • 155 citations

Modulated expression of notch1 during thymocyte development

1996 • 147 citations

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

1996 • 141 citations

Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.

1993 • 141 citations

Intrathymic maturation of murine T lymphocytes from CD8+ precursors.

1989 • 134 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

Expression of the CD4 gene requires a Myb transcription factor.

1992 • 127 citations

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.

1991 • 116 citations

An Enhancer That Directs Lineage-Specific Expression of CD8 in Positively Selected Thymocytes and Mature T Cells

1997 • 113 citations

Production, selection, and maturation of thymocytes with high surface density of TCR.

1994 • 113 citations

Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins.

1993 • 111 citations

Surface Molecules That Drive T Cell Development In Vitro in the Absence of Thymic Epithelium and in the Absence of Lineage-Specific Signals

1997 • 110 citations

The CD8 coreceptor revisited: One chain good, two chains better

1994 • 99 citations

Development of Mature CD8⁺Thymocytes: Selection Rather Than Instruction?

1993 • 94 citations

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

1992 • 93 citations

Elf-1 binds to a critical element in a second CD4 enhancer.

1994 • 92 citations

Positive selection of T lymphocytes on fibroblasts

1993 • 92 citations

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.

1995 • 84 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

Thymic selection and cell division.

1995 • 83 citations

A Region in the CD8 Gene Locus That Directs Expression to the Mature CD8 T Cell Subset in Transgenic Mice

1997 • 75 citations

Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor β chain-independent pathway.

1995 • 74 citations

CD8 Lineage Commitment in the Absence of CD8

1997 • 74 citations

Positive selection of thymocytes involves sustained interactions with the thymic microenvironment.

1995 • 70 citations

A Myc-Associated Zinc Finger Protein Binding Site Is One of Four Important Functional Regions in the CD4 Promoter

1995 • 69 citations

Identification and characterization of a human CD4 silencer

1996 • 64 citations

A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice.

1997 • 63 citations

TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis.

1997 • 62 citations

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.

1993 • 62 citations

Specific expression of the human CD4 gene in mature CD4+ CD8- and immature CD4+ CD8+ T cells and in macrophages of transgenic mice.

1994 • 56 citations

The c-kit+ Maturation Pathway in Mouse Thymic T Cell Development: Lineages and Selection

1996 • 56 citations

Positive selection of CD4+ and CD8+ T cells

1996 • 55 citations

Repetitive Elements form a Cruciform Structure that Regulates the Function of the Human CD8α T Cell-specific En hancer

1995 • 52 citations

Lineage Commitment in the Thymus: Only the Most Differentiated (TCRhibcl-2hi) Subset of CD4+CD8+Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis

1996 • 51 citations

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus

1997 • 51 citations

T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45.

1997 • 48 citations

Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3.

1995 • 48 citations

Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes.

1996 • 46 citations

Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer.

1993 • 46 citations

Peptide-Induced Positive Selection of TCR Transgenic Thymocytes in a Coreceptor-Independent Manner

1997 • 45 citations

Asymmetric Redundancy in CD4 Silencer Function

1996 • 42 citations

Role of TCR specificity in CD4 versus CD8 lineage commitment.

1995 • 39 citations

T-cell lymphomas in v-Myb transgenic mice.

1996 • 38 citations

Positive selection induces CD4 promoter and enhancer function

1997 • 37 citations

T cell receptor targeting to thymic cortical epithelial cellsin vivo induces survival, activation and differentiation of immature thymocytes

1993 • 36 citations

Bone marrow-derived cells fail to induce positive selection in thymus reaggregation cultures.

1996 • 36 citations

CD4+8- and CD4-8+ mature thymocytes require different post-selection processing for final development.

1993 • 34 citations

Tissue-specific expression of human CD4 in transgenic mice.

1993 • 31 citations

Functional importance of the cyclic AMP response element-like decamer motif in the CD8 alpha promoter.

1993 • 27 citations

Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes.

1995 • 27 citations

CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection

1996 • 26 citations

Thymocytes control the CD4 gene differently from mature T lymphocytes

1997 • 22 citations

Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: Rescue of CD4 T cell lineage without co‐engagement of TcR/CD4 by MHC class II

1995 • 19 citations

Discrimination between thymic epithelial cells and peripheral antigen-presenting cells in the induction of immature T cell differentiation

1994 • 18 citations

Commitment of Immature CD4+8+ Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains

1997 • 17 citations

Human CD8α expression in NK cells but not cytotoxic T cells of transgenic mice

1996 • 16 citations

Post-transcriptional regulation associated with control of human CD8A expression of CD4 + T cells

1996 • 13 citations

In vitro positive selection of alpha beta TCR transgenic thymocytes by a conditionally immortalized cortical epithelial clone

1997 • 10 citations

Sequential Occurrence of Positive and Negative Selection during T Lymphocyte Maturation

1993 • 5 citations

Early molecular events induced by TCR signaling in immature CD4+ CD8+ thymocytes

1995 • 3 citations

Deleted Work

1955 • 0 citations