Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

1982 • 1,406 citations

NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN

1988 • 1,233 citations

The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

1980 • 1,114 citations

Compilation of vertebrate-encoded transcription factors

1992 • 934 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

MyoD family: a paradigm for development?

1990 • 776 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.

1991 • 545 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Construction of plasmids that expressE.coli β-galactosidase in mammalian cells

1989 • 458 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Evolution of the master Alu gene(s)

1991 • 299 citations

A sensitive method for the detection of beta-galactosidase in transfected mammalian cells.

1991 • 283 citations

The Structure of the CD4 and CD8 Genes

1987 • 276 citations

Subsets of CD3⁺ (T cell receptor α/β or γ/δ) and CD3⁻ lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood

1990 • 269 citations

Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.

1992 • 260 citations

Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development

1989 • 222 citations

LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes.

1991 • 203 citations

Substitution at residue 227 of H–2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes

1989 • 198 citations

Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element.

1988 • 185 citations

αβ lineage-specific expression of the α T cell receptor gene by nearby silencers

1989 • 182 citations

Kinetics and mechanism in the reaction of gene regulatory proteins with DNA

1984 • 181 citations

A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.

1991 • 178 citations

Evolutionarily conserved Ets family members display distinct DNA binding specificities.

1992 • 175 citations

A second subunit of CD8 is expressed in human T cells.

1988 • 155 citations

UC 729-6, a human lymphoblastoid B-cell line useful for generating antibody-secreting human-human hybridomas.

1983 • 149 citations

A Transcriptional Enhancer 3′ of C _β2 in the T Cell Receptor β Locus

1988 • 118 citations

Cytogenetic Study of Human Lymphoid T -Cell Lines Derived From Lymphocytic Leukemia 2

1974 • 116 citations

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene.

1991 • 116 citations

Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression.

1992 • 108 citations

Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.

1984 • 108 citations

A phorbol ester response element within the human T-cell receptor beta-chain enhancer.

1992 • 103 citations

Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.

1988 • 101 citations

The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.

1988 • 88 citations

A Negative Regulatory Element with Properties Similar to Those of Enhancers Is Contained within an Alu Sequence

1989 • 87 citations

Co-engagement of CD8 with the T cell receptor is required for negative selection

1991 • 85 citations

Involvement of Alu sequences in the cell-specific regulation of transcription of the gamma chain of Fc and T cell receptors.

1993 • 81 citations

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules

1991 • 81 citations

Association of CD8 with p56lck is required for early T cell signalling events.

1991 • 79 citations

Differential expression and regulation of the human CD8α and CD8β chains

1990 • 79 citations

Functional analysis of the murine T-cell receptor beta enhancer and characteristics of its DNA-binding proteins.

1990 • 75 citations

CD8 is required during positive selection of CD4-/CD8+ T cells.

1990 • 65 citations

Transcriptional regulation during T-cell development: the α TCR gene as a molecular model

1992 • 64 citations

A second chain of human CD8 is expressed on peripheral blood lymphocytes.

1988 • 64 citations

Identification of an Essential Site for Transcriptional Activation within the Human T-Cell Receptor δ Enhancer

1991 • 58 citations

Functionally distinct isoforms of the CRE-BP DNA-binding protein mediate activity of a T-cell-specific enhancer.

1992 • 53 citations

Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene.

1989 • 52 citations

Identification of a T-cell-specific transcriptional enhancer located 3' of C gamma 1 in the murine T-cell receptor gamma locus.

1991 • 51 citations

Predicted Structural Similarities of the DNA Binding Domains of c-Myc and Endonuclease Eco RI

1992 • 49 citations

Regulation of transcription of the human T cell antigen receptor delta chain gene. A T lineage-specific enhancer element is located in the J delta 3-C delta intron.

1990 • 47 citations

Active T-Cell Receptor Genes Have Intron Deoxyribonuclease Hypersensitive Sites

1985 • 42 citations

Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain.

1991 • 42 citations

Alu interspersed repeats: selfish DNA or a functional gene family?

1990 • 36 citations

A transcriptional enhancer of the mouse T cell receptor δ gene locus

1991 • 34 citations

Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif.

1992 • 31 citations

Tissue-specific nuclear factors mediate expression of the CD3 delta gene during T cell development.

1990 • 31 citations

Recent duplication of the two human CD8 beta-chain genes.

1992 • 26 citations

Chromatin configuration of the human CD2 gene locus during T-cell development.

1989 • 24 citations

Towards a molecular understanding of T-cell differentiation

1991 • 24 citations

Identification and functional analysis of the transcriptional enhancer of the human T cell receptor β gene

1991 • 22 citations

Differential binding of human nuclear proteins to Alu subfamilies

1992 • 22 citations

FK506 and rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA.

1992 • 21 citations

T cell receptor beta gene has two downstream DNase I hypersensitive regions. Possible mechanisms of tissue- and stage-specific gene regulation.

1989 • 20 citations

Structure and expression of the gene encoding CD8α chain (Leu-2/T8)

1989 • 19 citations

Binding specificity of human nuclear protein interacting with the Alu-family DNA repeats

1991 • 17 citations

Multiple nuclear factors interact with sequences within the J beta 2-C beta 2 intron of the murine T cell receptor beta-chain gene.

1990 • 10 citations

The human T cell antigen Leu-2 (T8) is encoded on chromosome 2

1985 • 9 citations

Identification of tissue specific nuclear proteins: DNA sequence and protein binding regions in the T cell receptor beta J-C intron

1990 • 7 citations

Deleted Work

1955 • 0 citations