Pre-clinical Pharmacology of Atypical Antipsychotic Drugs: A Selective Review

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine

1992 • 1,420 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

A Canadian Multicenter Placebo-Controlled Study of Fixed Doses of Risperidone and Haloperidol in the Treatment of Chronic Schizophrenic Patients

1993 • 884 citations

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

1975 • 874 citations

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

1994 • 592 citations

Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

1993 • 588 citations

Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

1993 • 510 citations

The Mechanism of Action of Novel Antipsychotic Drugs

1991 • 410 citations

Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study

1990 • 407 citations

Biochemical profile of risperidone, a new antipsychotic.

1988 • 393 citations

Treatment of the Neuroleptic-Nonresponsive Schizophrenic Patient

1992 • 332 citations

Seroquel: biochemical profile of a potential atypical antipsychotic

1993 • 271 citations

Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition

1989 • 266 citations

Effects of antipsychotic drugs on serotonin receptors.

1991 • 260 citations

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

1989 • 258 citations

Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.

1993 • 254 citations

Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum.

1989 • 238 citations

Comparison of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat

1983 • 212 citations

Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons

1985 • 196 citations

Survey on the pharmacodynamics of the new antipsychotic risperidone

1994 • 195 citations

Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors.

1992 • 192 citations

Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH-DPAT in relation to other “D-2-like” agonists

1993 • 183 citations

Typical and atypical antipsychotic occupancy of D2 and S2 receptors: An autoradiographic analysis in rat brain

1986 • 177 citations

Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites

1990 • 173 citations

Midbrain dopamine system electrophysiological functioning: A review and new hypothesis

1991 • 162 citations

5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine

1992 • 160 citations

Ritanserin, a Selective 5-HT_2/1C Antagonist, and Negative Symptoms in Schizophrenia

1993 • 153 citations

Behavioral aspects of serotonin-dopamine interaction in the monkey

1985 • 146 citations

Serotonergic involvement in haloperidol-induced catalepsy.

1993 • 144 citations

Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy

1979 • 127 citations

Effects of atypical antipsychotic agents on social behavior in rodents

1993 • 126 citations

Effects of acute and chronic treatments with clozapine and haloperidol on serotonin (5-HT2) and dopamine (D2) receptors in the rat brain

1989 • 122 citations

Leponex ? associated granulocytopenia: a review of the situation

1989 • 118 citations

The effect of serotonergic agents on haloperidol-induced catalepsy

1990 • 118 citations

Seroquel: electrophysiological profile of a potential atypical antipsychotic

1993 • 117 citations

Chronic treatment with clozapine or haloperidol differentially regulates dopamine and serotonin receptors in rat brain

1990 • 112 citations

Evidence for Different States of the Dopamine Dl Receptor: Clozapine and Fluperlapine May Preferentially Label an Adenylate Cyclase‐Coupled State of the Dl Receptor

1986 • 104 citations

Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug

1993 • 103 citations

Dopamine and the pharmacology of schizophrenia: The state of the evidence

1974 • 99 citations

Dopamine D1, D2 and serotonin2 receptor occupation by typical and atypical antipsychotic drugs in vivo.

1993 • 98 citations

An Open Trial of Buspirone Added to Neuroleptics in Schizophrenic Patients

1991 • 97 citations

An open clinical and biochemical study of ritanserin in acute patients with schizophrenia

1994 • 97 citations

Effect of typical and atypical antipsychotic drugs on 5-HT2 receptor density in rat cerebral cortex

1989 • 91 citations

Differential Effect of Subchronic Treatment with Various Neuroleptic Agents on Serotonin₂ Receptors in Rat Cerebral Cortex

1986 • 80 citations

Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain

1984 • 74 citations

Differential effects of repeated treatment with haloperidol and clozapine on dopamine release and metabolism in the striatum and the nucleus accumbens.

1991 • 69 citations

Pilot Clinical Investigation of Risperidone in the Treatment of Psychotic Patients

1990 • 69 citations

Clozapine has sub-micromolar affinity for 5-HT1A receptors in human brain tissue

1992 • 64 citations

Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro

1987 • 63 citations

Selective 5-hydroxytryptamine2 receptor antagonists protect against the neurotoxicity of methylenedioxymethamphetamine in rats.

1990 • 61 citations

Sertindole, a new neuroleptic with extreme selectivity on A10 versus A9 dopamine neurones in the rat

1990 • 59 citations

The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors.

1992 • 59 citations

Effects of Clozapine and Fluphenazine Treatment on Responses to m-Chlorophenylpiperazine Infusions in Schizophrenia

1993 • 58 citations

Interaction of the atypical neuroleptic clozapine with 5-HT3 receptors in the cerebral cortex and superior cervical ganglion of the rat

1990 • 56 citations

Effects of ICI 169,369, a selective serotonin2 antagonist, in electrophysiological tests predictive of antipsychotic activity.

1989 • 54 citations

Novel Antipsychotic Drugs

1993 • 48 citations

5-HT2 receptor antagonists reverse amphetamine-induced slowing of dopaminergic neurons by interfering with stimulated dopamine synthesis.

1992 • 45 citations

Serotonergic drugs do not substitute for clozapine in clozapine-trained rats in a two-lever drug discrimination procedure

1992 • 44 citations

Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine.

1994 • 44 citations

Clozapine: Mechanism of Action in Relation to its Clinical Advantages

1990 • 35 citations

Effect of amperozide on rat cortical 5-HT2 and striatal and limbic dopamine D2 receptor occupancy: Implications for antipsychotic action

1992 • 34 citations

Chronic clozapine treatment decreases 5-hydroxytryptamine1C receptor density in the rat choroid plexus: comparison with haloperidol.

1993 • 32 citations

Potency mismatch for behavioral and biochemical effects by dopamine receptor antagonists: implications for the mechanism of action of clozapine

1993 • 31 citations

Haloperidol and clozapine treatment and their effect onM-chlorophenylpiperazine-mediated responses in schizophrenia: implications for the mechanism of action of clozapine

1993 • 29 citations

Neuroleptic interaction with the serotoninergic-dopaminergic mechanisms in the nucleus accumbens

1978 • 23 citations

The cimetidine-induced increase in prolactin secretion in schizophrenia: effect of clozapine

1993 • 17 citations

Comparison of the effects of various typical and atypical antipsychotic drugs on the suppressant action of 2‐methylserotonin on medial prefrontal cortical cells in the rat

1991 • 17 citations

Effect of haloperidol and clozapine on (+)SKF 10,047-induced dopamine release: role of 5-HT3 receptors

1992 • 13 citations

Advances in the Neurobiology of Schizophrenia

1996 • 11 citations

Time Course of Dopamine‐D₂ and Serotonin‐5‐HT₂ Receptor Occupancy Rates by Haloperidol and Clozapine In Vivo

1993 • 11 citations

The effects of clozapine on dopamine, 5-HT, and glutamate release in the rat medial prefrontal cortex

1991 • 8 citations

Dopamine-2 and serotonin-2 receptor indices in clozapine treated schizophrenic patients

1993 • 3 citations

Deleted Work

1955 • 0 citations