Is Schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

Synaptic density in human frontal cortex — Developmental changes and effects of aging

1979 • 2,587 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

Positron emission tomography study of human brain functional development

1987 • 1,531 citations

Sexual Differentiation of the Central Nervous System

1981 • 1,475 citations

Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks

1976 • 1,444 citations

Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?

1982 • 1,352 citations

Schizophrenia: The epigenetic puzzle

1982 • 1,194 citations

Gonadal Steroid Induction of Structural Sex Differences in the Central Nervous System

1984 • 1,170 citations

Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex

1986 • 1,126 citations

The Journal of Neuropsychiatry and Clinical Neurosciences

1992 • 1,058 citations

Hypofrontality in Neuroleptic-Naive Patients and in Patients With Chronic Schizophrenia

1992 • 882 citations

Is schizophrenia a neurodevelopmental disorder?

1987 • 838 citations

Elimination of Synapses in the Developing Nervous System

1980 • 807 citations

Development of Cortical Circuitry and Cognitive Function

1987 • 794 citations

Activity-Dependent Decrease in NMDA Receptor Responses During Development of the Visual Cortex

1992 • 731 citations

Postmortem Evidence of Structural Brain Changes in Schizophrenia

1986 • 684 citations

ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIA

1974 • 673 citations

Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development

1993 • 660 citations

Human Cerebral Hemispheres Develop at Different Rates and Ages

1987 • 611 citations

A neurohistological correlate of schizophrenia.

1984 • 584 citations

Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage

1993 • 561 citations

Changes in sleep cycle patterns with age

1974 • 550 citations

The development of synapses in striate cortex of man.

1987 • 523 citations

Brain Morphology and Schizophrenia

1992 • 508 citations

Quantitative Cytoarchitectural Studies of the Cerebral Cortex of Schizophrenics

1986 • 506 citations

Structural Abnormalities in the Frontal System in Schizophrenia

1986 • 489 citations

Schizophrenia, just the facts

1988 • 486 citations

Alterations in Brain High-Energy Phosphate and Membrane Phospholipid Metabolism in First-Episode, Drug-Naive Schizophrenics

1991 • 481 citations

Annals of the New York Academy of Sciences

1953 • 475 citations

Human Sleep, Sleep Loss and Behaviour

1993 • 458 citations

Limbic pathology in schizophrenia: The entorhinal region—a morphometric study

1988 • 441 citations

Magnetic Resonance Imaging of the Brain in Schizophrenia

1990 • 440 citations

The neurodevelopmental basis of sex differences in schizophrenia

1991 • 438 citations

Hippocampal Pathologic Findings in Schizophrenia

1989 • 437 citations

Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia

1992 • 421 citations

Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study

1992 • 410 citations

Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia

1989 • 392 citations

Negative Symptoms and Hypofrontality in Chronic Schizophrenia

1992 • 391 citations

The Genesis of the Eeg

1972 • 383 citations

The schizophrenic disorders: Long-term patient and family studies

1978 • 379 citations

Automation of clinical electroencephalography

1974 • 376 citations

Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia

1985 • 373 citations

Infants at Risk for Schizophrenia: Sequelae of a Genetic Neurointegrative Defect

1992 • 358 citations

Cortical Circuits: Synaptic Organization of the Cerebral Cortex Structure, Function, and Theory

1989 • 335 citations

Frontostriatal Disorder of Cerebral Metabolism in Never-Medicated Schizophrenics

1992 • 330 citations

Electroencephalography (EEG) of human sleep : clinical applications

1974 • 319 citations

The Frontal Lobes, Basal Ganglia, and Temporal Lobes as Sites for Schizophrenia

1990 • 312 citations

Involvement of the N -Methyl D-Aspartate (NMDA) Receptor in Synapse Elimination During Cerebellar Development

1992 • 308 citations

Visual and auditory sentence processing: A developmental analysis using event‐related brain potentials

1992 • 301 citations

The Schizophrenic Disorders: Long-Term Patient and Family Studies

1979 • 297 citations

NMDA receptor antagonists disrupt the retinotectal topographic map

1989 • 293 citations

Magnetic Resonance Imaging Abnormalities in Lenticular Nuclei and Cerebral Cortex in Schizophrenia

1991 • 271 citations

On the Genesis of Sexual Differentiation of the Central Nervous System: Morphogenetic Consequences of Steroidal Exposure and Possible Role of α-Fetoprotein

1984 • 263 citations

Structural abnormalities in deficit and nondeficit schizophrenia

1993 • 260 citations

Cortical Pruning and the Development of Schizophrenia: A Computer Model

1989 • 259 citations

Changes in synaptic density in motor cortex of rhesus monkey during fetal and postnatal life

1989 • 250 citations

Event-related potentials in schizophrenia: their biological and clinical correlates and new model of schizophrenic pathophysiology

1991 • 247 citations

Decreased hippocampal expression of a glutamate receptor gene in schizophrenia

1991 • 241 citations

THE DENSITY OF SYNAPSES AND NEURONS IN NORMAL, MENTALLY DEFECTIVE AND AGEING HUMAN BRAINS

1975 • 223 citations

Reduction of cortical volume in schizophrenia on magnetic resonance imaging

1993 • 222 citations

Minor Physical Anomalies in Schizophrenia

1989 • 220 citations

Heterogeneous Targets of Dopamine Synapses in Monkey Prefrontal Cortex Demonstrated by Serial Section Electron Microscopy: A Laminar Analysis Using the Silver-enhanced Diaminobenzidine Sulfide (SEDS) Immunolabeling Technique

1993 • 209 citations

Age and Regional Cerebral Blood Flow at Rest and During Cognitive Activity

1987 • 204 citations

Post-mortem Study of Chronic Schizophrenic Brains

1987 • 203 citations

LATE CHILDHOOD CHANGES IN BRAIN MORPHOLOGY OBSERVABLE WITH MRI

1990 • 201 citations

Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia

1989 • 201 citations

Electroencephalographic Sleep in Young, Never-Medicated Schizophrenics

1987 • 196 citations

Schizophrenia: developmental neuroscience and pathobiology

1993 • 196 citations

Automation of clinical electroencephalography

1975 • 195 citations

Down's dyndrome and Alzheimer's disease: dendritic spine counts in the hippocampus

1990 • 194 citations

Parallel Distributed Processing and the Emergence of Schizophrenic Symptoms

1993 • 193 citations

Electroencephalographic Sleep Abnormalities in Schizophrenia

1992 • 193 citations

Dopamine receptors in human brain: Autoradiographic distribution of D1 sites

1989 • 191 citations

Neural development is regulated by classical neurotransmitters: Dopamine D2 receptor stimulation enhances neurite outgrowth

1992 • 185 citations

Are Adult Learning Mechanisms Also Used for Development?

1992 • 171 citations

Gamma distribution model describes maturational curves for delta wave amplitude, cortical metabolic rate and synaptic density

1990 • 168 citations

Structural Brain Deficits in Schizophrenia

1981 • 167 citations

Estrogen formation and binding in the cerebral cortex of the developing rhesus monkey.

1986 • 165 citations

Strong Inference, Theory Testing, and the Neuroanatomy of Schizophrenia

1993 • 164 citations

Altered Modulation of Prefrontal and Subcortical Brain Activity in Newly Diagnosed Schizophrenia and Schizophreniform Disorder

1991 • 156 citations

Cortical circuits: Synaptic organization of the cerebral cortex. Structure, function and theory

1990 • 154 citations

Further Evidence of Abnormal Non-Rapid-Eye-Movement Sleep in Schizophrenia

1985 • 146 citations

Do NMDA receptors have a critical function in visual cortical plasticity?

1993 • 131 citations

Gender and Schizophrenia: An Introduction and Synthesis of Findings

1990 • 126 citations

Period and amplitude analysis of 0.5–3c/sec activity in NREM sleep of young adults

1978 • 125 citations

Electroencephalographic and eye movement patterns during sleep in chronic schizophrenic patients

1967 • 120 citations

EEG Sleep of Normal Healthy Children. Part I: Findings Using Standard Measurement Methods

1984 • 119 citations

The organization of the cerebral cortex

1982 • 118 citations

Estrogen Effects on the Synaptology and Neural Membranes of the Rat Hypothalamic Arcuate Nucleus1

1990 • 117 citations

Immunocytochemistry of glutamate at the synaptic level.

1990 • 115 citations

Sleep Disturbance in Acute Schizophrenic Patients

1970 • 114 citations

Electroencephalographic sleep in schizophrenia: A critical review

1990 • 109 citations

Magnetic Resonance Imaging in Schizophrenia

1991 • 108 citations

EEG coherence in unmedicated schizophrenic patients

1989 • 108 citations

An evaluation of structural and functional prefrontal deficits in schizophrenia: MRI and neuropsychological measures

1992 • 105 citations

Functional and Anatomical Brain Imaging: Impact on Schizophrenia Research

1987 • 102 citations

Sex and Schizophrenia: Vive la Différence

1992 • 101 citations

Magnetic Resonance Brain Images in Schizophrenic and Normal Subjects: Influence of Diagnosis and Education

1988 • 96 citations

Decreased slow-wave sleep and enlarged lateral ventricles in schizophrenia.

1988 • 95 citations

EEG coherence and power in the discrimination of psychiatric disorders and medication effects

1986 • 89 citations

Rapid Eye Movement Sleep Eye Movements in Schizophrenia and Depression

1993 • 81 citations

Electroencephalography (EEG) of human sleep — Clinical applications

1975 • 81 citations

Ontogeny of delta activity during human sleep

1977 • 78 citations

Sleep EEG variables in young schizophrenic and depressive patients

1988 • 74 citations

Effects of neonatal thermal lesioning of the mesocortical dopaminergic projection on the development of the rat prefrontal cortex

1987 • 74 citations

Deficient NMDA-mediated glutamate release from synaptosomes of schizophrenics

1991 • 71 citations

Midsagittal cortical pathomorphology of schizophrenia: A magnetic resonance imaging study

1989 • 69 citations

Left Cerebral Hemisphere Hypodensity in Discordant Schizophrenic Twins

1987 • 69 citations

Negative Schizophrenic Symptoms: Pathophysiology and Clinical Implications

1991 • 67 citations

Age at Puberty and Mental Illness

1989 • 63 citations

Schizophrenia: A life-course developmental perspective.

1991 • 61 citations

Neural Plasticity in Schizophrenia

1985 • 60 citations

EEG coherence of prefrontal areas in normal and schizophrenic males during perceptual activation

1991 • 58 citations

Abnormalities of brain structure and density in schizophrenia.

1984 • 58 citations

Effects of Metabolic Perturbation on Plasma Homovanillic Acid in Schizophrenia

1993 • 55 citations

Structural brain pathology in schizophrenia revisited *1Prefrontal cortex pathology is inversely correlated with cerebrospinal fluid levels of homovanillic acid

1987 • 54 citations

Synaptic reorganization in developing and adult nervous systems

1992 • 51 citations

Dopamine and the neural circuitry of primate prefrontal cortex: implications for schizophrenia research.

1992 • 50 citations

A neuroanatomical theory on the aetiology of schizophrenia

1980 • 46 citations

Cleverness and wisdom in 12‐year‐olds: Electrophysiological evidence for late maturation of the frontal lobe

1992 • 45 citations

Hippocampal Dysgenesis in Mutant Mouse and Schizophrenic Man: Is There a Relationship?

1993 • 44 citations

Positron emission tomography and magnetic resonance imaging: A review and a local circuit neurons hypo(dys)function hypothesis of schizophrenia

1991 • 39 citations

Electroencephalographic Sleep of Healthy Children. Part II: Findings Using Automated Delta and REM Sleep Measurement Methods

1987 • 37 citations

General Organization of the Cerebral Cortex

1989 • 37 citations

Computerised Tomography in Newly Diagnosed Schizophrenia and Schizophreniform Disorder

1993 • 36 citations

Clinical Correlates of Cerebral Ventricular Enlargement in Schizophrenia

1992 • 36 citations

Familial and sporadic schizophrenia: visual evoked potential differences

1988 • 33 citations

The relationship between attention and slow-wave sleep in chronic schizophrenia [proceedings].

1977 • 32 citations

Sleep Stage Deficits in Chronic Schizophrenia

1972 • 28 citations

Specific imbalance of right and left sided motor neuron excitability in schizophrenia.

1988 • 18 citations

Schizophrenia and the normal functional development of the prefrontal cortex

1990 • 15 citations

Le sommeil de nuit normal et pathologique. Etudes electroencéphalographiques

1966 • 15 citations

NEURODEVELOPMENTAL ABNORMALITIES IN SCHIZOPHRENIA.

1992 • 13 citations

A morphometric analysis of prefrontal areas 9 and 46 in the schizophrenic and normal human brain

1993 • 13 citations

The study of schizophrenia via in vivo 31P and 1H MRS

1993 • 12 citations

The Development of Liability to Schizophrenia: Early and Late Developmental Models

1991 • 12 citations

Role of excitatory amino acid neurotransmission in synaptic plasticity and pathology. An integrative hypothesis concerning the pathogenesis and evolutionary advantages of schizophrenia-related genes

1990 • 12 citations

[Schizophrenia: a psychobiological view].

1996 • 9 citations

Normal frontal lobe gray matter-white matter CT volume ratio in children

1985 • 8 citations

ALL-NIGHT SLEEP ABNORMALITIES IN SCHIZOPHRENIA - RELATIONSHIP TO CT BRAIN VENTRICULAR SIZE AND CLINICAL CHARACTERISTICS

1989 • 7 citations

A MORPHOMETRIC STUDY OF THE CINGULATE CORTEX IN MOOD DISORDER AND SCHIZOPHRENIA

1994 • 5 citations

BPRS symptom factors and sleep variables in schizophrenia

1991 • 4 citations

Developmentally regulated changes in brain membrane metabolism

1992 • 4 citations

Temporal, but not frontal, cortical glutamatergic deficits in schizophrenia

1993 • 3 citations

Calretinin- and calbindin-D28K-immunoreactive interneurons in prefrontal and anterior cingulate cortices in schizophrenia

1993 • 2 citations

Could aberrant neurotrophic activity cause schizophrenia?

1993 • 1 citations

Deleted Work

1955 • 0 citations