Flash photolysis of caged inositol 1,4,5-trisphosphate activates plasma membrane calcium current in human T cells.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

1989 • 1,119 citations

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

1989 • 1,039 citations

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

1986 • 775 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

1984 • 734 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

Solubilization, purification, and characterization of an inositol trisphosphate receptor.

1988 • 650 citations

Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor

1989 • 531 citations

Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels

1987 • 529 citations

CALCIUM CHANNELS: Mechanisms of Selectivity, Permeation, and Block

1987 • 528 citations

Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles

1989 • 512 citations

Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons

1989 • 431 citations

Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel

1992 • 426 citations

Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.

1989 • 402 citations

Structure of a novel InsP3 receptor.

1991 • 383 citations

The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor.

1990 • 339 citations

The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment.

1990 • 326 citations

K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion

1984 • 308 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di-(tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes.

1991 • 243 citations

Inositol 1,4,5-Trisphosphate-Activated Calcium Channels

1992 • 236 citations

IP ₃ Receptor: Localization to Plasma Membrane of T Cells and Cocapping with the T Cell Receptor

1992 • 213 citations

Excitation-contraction coupling in vertebrate skeletal muscle: A tale of two calcium channels

1991 • 199 citations

Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate

1991 • 182 citations

Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.

1984 • 175 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells

1989 • 163 citations

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

1986 • 151 citations

Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.

1992 • 120 citations

The ultrastructure of patch-clamped membranes: a study using high voltage electron microscopy.

1991 • 111 citations

Kinetics of the conductance evoked by noradrenaline, inositol trisphosphate or Ca2+ in guinea‐pig isolated hepatocytes.

1990 • 84 citations

Special Topic: Caged Compounds in Cellular Physiology

1990 • 84 citations

Photolabile precursors of inositol phosphates. Preparation and properties of 1-(2-nitrophenyl)ethyl esters of myo-inositol 1,4,5-trisphosphate

1989 • 84 citations

Regulation of CI− channels by multifunctional CaM kinase

1991 • 68 citations

Photochemical Manipulation of Divalent Cation Levels

1990 • 65 citations

Function of a Heterologous Muscarinic Receptor in T Cell Antigen Receptor Signal Transduction Mutants

1989 • 58 citations

Inositol 1,3,4,5-tetrakisphosphate stimulates calcium release from bovine adrenal microsomes by a mechanism independent of the inositol 1,4,5-trisphosphate receptor

1990 • 57 citations

Triggering of T-lymphocytes via Either T3-Ti or T11 Surface Structures Opens a Voltage-insensitive Plasma Membrane Calcium-permeable Channel: Requirement for Interleukin-2 Gene Function

1989 • 46 citations

Sustained Ca2+ signaling in mouse lacrimal acinar cells due to photolysis of “caged” glycerophosphoryl-myo-inositol 4,5-bisphosphate.

1992 • 37 citations

Ca2+ entry in T cells is activated by emptying the inositol 1,4,5-trisphosphate sensitive Ca2+ pool

1990 • 33 citations