Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Calcium signaling

1995 • 1,905 citations

Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum

1991 • 1,699 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

1989 • 1,119 citations

Capacitative calcium entry

1995 • 1,112 citations

Responses of retinal rods to single photons.

1979 • 971 citations

The structure and function of proline-rich regions in proteins

1994 • 965 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release

1991 • 843 citations

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors

1992 • 732 citations

Isolation of a putative phospholipase c gene of drosophila, norpA, and its role in phototransduction

1988 • 665 citations

Abnormal Electroretinogram from a Drosophila Mutant

1969 • 642 citations

The Drosophila ninaE gene encodes an opsin

1985 • 545 citations

Isolation and structure of a rhodopsin gene from D. melanogaster

1985 • 481 citations

Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene

1992 • 441 citations

Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger

1993 • 363 citations

Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate

1984 • 337 citations

Arrestin Function in Inactivation of G Protein-Coupled Receptor Rhodopsin in Vivo

1993 • 313 citations

myo-inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors

1984 • 310 citations

The Drosophila ninaC locus encodes two photoreceptor cell specific proteins with domains homologous to protein kinases and the myosin heavy chain head

1988 • 306 citations

The ninaA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein

1989 • 288 citations

Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization

1993 • 262 citations

Induction of photoreceptor voltage noise in the dark in Drosophila mutant

1975 • 254 citations

Photoreceptor Deactivation and Retinal Degeneration Mediated by a Photoreceptor-Specific Protein Kinase C

1991 • 240 citations

Activation of recombinant trp by thapsigargin in Sf9 insect cells

1994 • 226 citations

The ANK repeat: a ubiquitous motif involved in macromolecular recognition

1992 • 225 citations

Probability of Occurrence of Discrete Potential Waves in the Eye of Limulus

1964 • 216 citations

A second opsin gene expressed in the ultraviolet-sensitive R7 photoreceptor cells of Drosophila melanogaster

1987 • 215 citations

Nonphototactic Mutants in a Study of Vision of Drosophila

1969 • 207 citations

Coupling of photoexcited rhodopsin to inositol phospholipid hydrolysis in fly photoreceptors.

1987 • 193 citations

A rhodopsin gene expressed in photoreceptor cell R7 of the Drosophila eye: homologies with other signal-transducing molecules

1987 • 193 citations

Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues

1995 • 193 citations

Whole-cell recordings of the light induced current in dissociated Drosophila photoreceptors: evidence for feedback by calcium permeating the light-sensitive channels

1991 • 192 citations

Neurogenetics : genetic approaches to the nervous system

1979 • 188 citations

A Drosophila mutant defective in extracellular calcium-dependent photoreceptor deactivation and rapid desensitization

1991 • 186 citations

Inositol phosphates and Ca ²⁺ entry: toward a proliferation or a simplification?

1992 • 184 citations

Localization of Drosophila retinal degeneration B, a membrane-associated phosphatidylinositol transfer protein

1993 • 183 citations

Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae.

1994 • 182 citations

INHIBITION BY NEOMYCIN OF POLYPHOSPHOINOSITIDE TURNOVER IN SUBCELLULAR FRACTIONS OF GUINEA‐PIG CEREBRAL CORTEX IN VITRO

1976 • 182 citations

Signal Transduction in Drosophila Photoreceptors

1995 • 178 citations

Regulation of PLC-mediated signalling in vivo by CDP-diacylglycerol synthase

1995 • 169 citations

Calcium influx and its control by calcium release

1993 • 167 citations

Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase

1992 • 158 citations

Transcript localization of four opsin genes in the three visual organs of Drosophila; RH2 is ocellus specific

1988 • 156 citations

Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster.

1992 • 155 citations

Protein kinase C is required for light adaptation in Drosophila photoreceptors

1993 • 154 citations

Regulatory arrestin cycle secures the fidelity and maintenance of the fly photoreceptor cell.

1993 • 150 citations

Cyclic GMP is involved in the excitation of invertebrate photoreceptors

1986 • 147 citations

Cytosolic calcium transients: Spatial localization and role in drosophila photoreceptor cell function

1994 • 143 citations

Dependence of Calmodulin Localization in the Retina on the NINAC Unconventional Myosin

1993 • 142 citations

The localization of calcium release by inositol trisphosphate in Limulus photoreceptors and its control by negative feedback

1988 • 138 citations

The light response of drosophila photoreceptors is accompanied by an increase in cellular calcium: Effects of specific mutations

1994 • 137 citations

dgq: A drosophila gene encoding a visual system-specific Gα molecule

1990 • 137 citations

Excitation and adaptation of Limulus ventral photoreceptors by inositol 1,4,5 triphosphate result from a rise in intracellular calcium.

1986 • 134 citations

Isolation and structure of an arrestin gene from Drosophila.

1990 • 131 citations

The drosophila dgq gene encodes a Gα protein that mediates phototransduction

1994 • 129 citations

A 49-Kilodalton Phosphoprotein in the Drosophila Photoreceptor Is an Arrestin Homolog

1990 • 128 citations

Pressure injection of calcium both excites and adapts Limulus ventral photoreceptors.

1986 • 127 citations

Phosphatidylinositol 3-kinase activity is required for early endosome fusion

1995 • 119 citations

Twenty Drosophila visual system cDNA clones: one is a homolog of human arrestin.

1990 • 119 citations

The Molecular Mechanism of Photoreception

1986 • 118 citations

A novel protein encoded by the inad gene regulates recovery of visual transduction in drosophila

1995 • 117 citations

Drosophila homologs of two mammalian intracellular Ca2+-release channels: identification and expression patterns of the inositol 1,4,5- triphosphate and the ryanodine receptor genes

1992 • 116 citations

Photolysis of caged Ca2+ facilitates and inactivates but does not directly excite light-sensitive channels in Drosophila photoreceptors

1995 • 112 citations

Phosrestin I undergoes the earliest light-induced phosphorylation by a calcium/calmodulin-dependent protein kinase in drosophila photoreceptors

1994 • 111 citations

Light-induced reduction in excitation efficiency in the trp mutant of Drosophila.

1982 • 110 citations

Effects of Ca2+ chelators on purified inositol 1,4,5-trisphosphate (InsP3) receptors and InsP3-stimulated Ca2+ mobilization

1993 • 110 citations

Appearance of a Novel Ca2+ Influx Pathway in Sf9 Insect Cells Following Expression of the Transient Receptor Potential-like (trpl) Protein of Drosophila

1994 • 108 citations

Light- and GTP-activated hydrolysis of phosphatidylinositol bisphosphate in squid photoreceptor membranes.

1988 • 101 citations

The role of the inositol phosphate cascade in visual excitation of invertebrate microvillar photoreceptors.

1991 • 100 citations

Feedback inhibition by calcium limits the release of calcium by inositol trisphosphate in Limulus ventral photoreceptors

1990 • 99 citations

Role of intracellular calcium and sodium in light adaptation in the retina of the honey bee drone (Apis mellifera, L).

1976 • 96 citations

Adapting bump model for ventral photoreceptors of Limulus.

1982 • 88 citations

Light-dependent channels from excised patches of Limulus ventral photoreceptors are opened by cGMP.

1991 • 87 citations

Calcium-sequestering smooth endoplasmic reticulum in retinula cells of the blowfly

1982 • 84 citations

Chapter 5 Inositol lipid pathway in fly photoreceptors: Excitation, calcium mobilization and retinal degeneration

1991 • 81 citations

The Drosophila cation channel trpl expressed in insect Sf9 cells is stimulated by agonists of G‐protein‐coupled receptors

1995 • 77 citations

Light stimulates the rapid formation of inositol trisphosphate in squid retinas

1986 • 75 citations

Calcium- and inositol polyphosphate-sensitivity of the calcium-sequestering endoplasmic reticulum in the photoreceptor cells of the honeybee drone

1989 • 74 citations

Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors.

1994 • 74 citations

Photoreceptor Mutant of Drosophila : Is Protein Involved in Intermediate Steps of Phototransduction?

1976 • 73 citations

Calcium-dependent inactivation of light-sensitive channels in Drosophila photoreceptors.

1994 • 68 citations

Spontaneous activation of light-sensitive channels in Drosophila photoreceptors.

1994 • 68 citations

An eye-specific Gβ subunit essential for termination of the phototransduction cascade

1994 • 66 citations

Excitation of Limulus Photoreceptors by Vanadate and by a Hydrolysis-Resistant Analog of Guanosine Triphosphate

1981 • 65 citations

A Gβ protein in the drosophila compound eye is different from that in the brain

1991 • 63 citations

TRP, a protein essential for inositide-mediated Ca2+ influx is localized adjacent to the calcium stores in Drosophila photoreceptors

1995 • 63 citations

Topography of Ca2+-sequestering endoplasmic reticulum in photoreceptors and pigmented glial cells in the compound eye of the honeybee drone

1989 • 62 citations

Ca2+ is an obligatory intermediate in the excitation cascade of limulus photoreceptors

1993 • 62 citations

Inositol Lipid Cascade of Vision Studied in Mutant Flies

1988 • 58 citations

Kinetics of light-sensitive channels in vertebrate photoreceptors

1985 • 57 citations

Properties of photoreceptor-specific phospholipase C encoded by the norpA gene of Drosophila melanogaster.

1991 • 57 citations

Mechanisms and genetics of photoreceptors desensitization in Drosophila flies

1993 • 55 citations

Lanthanum reduces the excitation efficiency in fly photoreceptors.

1991 • 54 citations

Magnesium-dependent block of the light-activated and trp-dependent conductance in Drosophila photoreceptors

1995 • 53 citations

Injection of guanosine and adenosine nucleotides into Limulus ventral photoreceptor cells

1982 • 53 citations

Lanthanum mimicks the trp photoreceptor mutant of Drosophila in the blowfly Calliphora

1989 • 52 citations

Calcium Enables Photoreceptor Pigment Migration in A Mutant Fly

1984 • 50 citations

Purification and partial amino acid sequences of phosphoinositide-specific phospholipase C of Drosophila eye.

1990 • 47 citations

The inositol-lipid pathway is necessary for light excitation in fly photoreceptors.

1992 • 46 citations

Measurement of cytosolic Ca2+ concentration in Limulus ventral photoreceptors using fluorescent dyes.

1995 • 45 citations

Ca²⁺limits the development of the light response inDrosophilaphotoreceptors

1993 • 44 citations

Bumps, the Elementary Excitatory Responses of Invertebrates

1986 • 42 citations

Light-induced changes in the content of inositol phosphates in squid (Loligo pealei) retina

1987 • 41 citations

Structure of retinular cells in a Drosophila melanogaster visual mutant, rdgA, at early stages of degeneration

1988 • 37 citations

The characteristics of chemically induced noise inMusca photoreceptors

1985 • 36 citations

Bump latency distribution and bump adaptation of limulus ventral nerve photoreceptor in varied extracellular calcium concentrations

1983 • 35 citations

Cyclic nucleotides and inositol trisphosphate activate different components of the receptor current in Limulus ventral nerve photoreceptors

1993 • 35 citations

Intracellular Ca2+ concentration and latency of light-induced Ca2+ changes in photoreceptors of the honeybee drone

1994 • 32 citations

Chemical excitation and inactivation in photoreceptors of the fly mutants trp and nss.

1989 • 29 citations

Intracellular injection of heparin and polyamines. Effects on phototransduction in limulus ventral photoreceptors.

1993 • 28 citations

Three‐dimensional organization of endoplasmic reticulum in the ventral photoreceptors of Limulus

1994 • 25 citations

Termination of photoreceptor responses

1994 • 23 citations

Effects of intracellular Ca2+ chelation on the light response in Drosophila photoreceptors

1995 • 23 citations

Variations in the voltage response to single quanta of light in the photoreceptors of Locusta Migratoria

1983 • 20 citations

The latency of the response of Limulus photoreceptors to inositol trisphosphate lacks the calcium-sensitivity of that to light

1992 • 19 citations

On the Ca2+-dependence of inositol-phospholipid-specific phospholipase C of microvillar photoreceptors from Sepia officinalis

1994 • 16 citations

Two components of the receptor current are developed from distinct elementary signals in Limulus ventral nerve photoreceptor

1993 • 13 citations

Multi-step rhodopsin inactivation schemes can account for the size variability of single photon responses in Limulus ventral photoreceptors.

1994 • 11 citations

The molecular mechanism of photoreception

1987 • 8 citations

Deleted Work

1955 • 0 citations