Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

Expression of a large family of POU-domain regulatory genes in mammalian brain development

1989 • 828 citations

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

1988 • 771 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor.

1989 • 664 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene

1987 • 516 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Multiple sequence motifs are involved in SV40 enhancer function.

1986 • 511 citations

A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

1988 • 494 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter

1987 • 407 citations

A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

1988 • 399 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro

1987 • 386 citations

A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally.

1989 • 352 citations

Octamer binding proteins confer transcriptional activity in early mouse embryogenesis.

1989 • 338 citations

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter

1986 • 336 citations

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors

1988 • 334 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

The POU domain is a bipartite DNA-binding structure

1988 • 304 citations

Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA Motif

1988 • 304 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Glucocorticoid Receptor Mutants That Define a Small Region Sufficient for Enhancer Activation

1987 • 260 citations

Nuclear factor III, a novel sequence-specific DNA-binding protein from HeLa cells stimulating adenovirus DNA replication

1986 • 256 citations

OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts

1987 • 255 citations

Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.

1987 • 255 citations

An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes

1985 • 250 citations

A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain

1988 • 234 citations

Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.

1988 • 234 citations

Caenorhabditis elegans has scores of homoeobox-containing genes

1989 • 197 citations

The Adenovirus Major Late Transcription Factor Activates the Rat γ-Fibrinogen Promoter

1987 • 177 citations

Repression of the IgH Enhancer in Teratocarcinoma Cells Associated with a Novel Octamer Factor

1989 • 176 citations

Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements.

1988 • 174 citations

In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers.

1987 • 149 citations

The conserved decanucleotide from the immunoglobulin heavy chain promoter induces a very high transcriptional activity in B-cells when introduced into an heterologous promoter.

1987 • 144 citations

The Oct-2 protein binds cooperatively to adjacent octamer sites.

1989 • 132 citations

Independently evolving chicken histone H2B genes: identification of a ubiquitous H2B-specific 5′ element

1982 • 131 citations

Eukaryotic expression vectors for the analysis of mutant proteins

1989 • 126 citations

Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2

1988 • 113 citations

A single glutamic acid residue plays a key role in the transcriptional activation function of lambda repressor

1989 • 94 citations

Purification and characterization of nuclear factor III (origin recognition protein C), a sequence-specific DNA binding protein required for efficient initiation of adenovirus DNA replication.

1988 • 93 citations

Rapid test forin vivostability and DNA binding of mutated octamer binding proteins with ‘mini extracts’, prepared from a transfected cells

1989 • 91 citations

Role of the octamer motif in hybrid cell extinction of immunoglobulin gene expression: Extinction is dominant in a two enhancer system

1989 • 82 citations

Sequences closely related to an immunoglobulin gene promoter/enhancer element occur also upstream of other eukaryotic and of prokaryotic genes

1986 • 78 citations

Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif

1989 • 66 citations

Constraints on spacing between transcription factor binding sites in a simple adenovirus promoter.

1988 • 62 citations

No strict alignment is required between a transcriptional activator binding site and the "TATA box" of a yeast gene.

1988 • 56 citations

Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.

1988 • 52 citations

The octamer motif is a B-lymphocyte-specific regulatory element of the HLA-DR alpha gene promoter.

1989 • 47 citations

Nuclear factors binding to the human immunoglobulin heavy-chain gene enhancer

1987 • 34 citations

Both immunoglobulin promoter and enhancer sequences are targets for suppression in myeloma-fibroblast hybrid cells.

1988 • 34 citations

A distinct octamer-binding protein present in malignant melanoma cells

1988 • 31 citations

Genes Activated in the Presence of an Immunoglobulin Enhancer or Promoter Are Negatively Regulated by a T-Lymphoma Cell Line

1988 • 13 citations

Tissue specific gene expression

1990 • 6 citations

The testi-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa

1989 • 2 citations