Both immunoglobulin promoter and enhancer sequences are targets for suppression in myeloma-fibroblast hybrid cells.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Transcriptional selectivity of viral genes in mammalian cells

1986 • 722 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

Deletion of thymidine kinase activity from L cells resistant to bromodeoxyuridine

1963 • 611 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene

1984 • 410 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro

1987 • 386 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences

1986 • 298 citations

Comparison of Total Sequence of a Cloned Rabbit β-Globin Gene and Its Flanking Regions with a Homologous Mouse Sequence

1979 • 256 citations

Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.

1987 • 255 citations

Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.

1984 • 205 citations

The conserved decanucleotide from the immunoglobulin heavy chain promoter induces a very high transcriptional activity in B-cells when introduced into an heterologous promoter.

1987 • 144 citations

Fine mapping of an immunoglobulin gene activator.

1984 • 144 citations

The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells.

1986 • 140 citations

Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity

1986 • 123 citations

Cell-type preference of immunoglobulin kappa and lambda gene promoters.

1985 • 118 citations

Synergism between immunoglobulin enhancers and promoters

1986 • 116 citations

The mouse immunoglobulin heavy-chain enhancer: effect on transcription in vitro and binding of proteins present in HeLa and lymphoid B cell extracts.

1986 • 114 citations

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

1987 • 113 citations

During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation

1986 • 105 citations

Transcriptional and posttranscriptional control of immunoglobulin mRNA production during Blymphocyte development

1986 • 99 citations

Isolation and characterization of temperature-sensitive mutants of Simian Virus 40

1972 • 96 citations

Identification and Characterization of Two Functional Domains within the Murine Heavy-Chain Enhancer

1988 • 81 citations

Nucleic Acids and Molecular Biology

1987 • 79 citations

Suppression of Immunoglobulin Synthesis by Cellular Hybridization

1971 • 65 citations

Repression of Rearranged μ Gene and Translocated c- myc in Mouse 3T3 Cells × Burkitt Lymphoma Cell Hybrids

1984 • 61 citations

Induction of immunoglobulin gene expression in mouse fibroblasts by cycloheximide treatment.

1984 • 53 citations

Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer.

1988 • 53 citations

Plasmidial maintenance in rodent fibroblasts of a BPV1-pBR322 shuttle vector without immediately apparent oncogenic transformation of the recipient cells.

1984 • 49 citations

Negative Regulation Contributes to Tissue Specificity of the Immunoglobulin Heavy-Chain Enhancer

1987 • 46 citations

Human Thymidine Kinase Gene: Molecular Cloning and Nucleotide Sequence of a cDNA Expressible in Mammalian Cells

1984 • 45 citations

IgG Synthesis in Hybrid Cells from an Antibody-producing Mouse Myeloma and an L Cell Substrain

1970 • 44 citations

Unrearranged immunoglobulin lambda variable region is transcribed in kappa-producing myelomas.

1984 • 29 citations

Extinction of Expression of Immunoglobulin Genes in Myeloma × Fibroblast Somatic Cell Hybrids

1987 • 27 citations

Induction of c-fos and AFP expression in a differentiating teratocarcinoma cell line

1986 • 25 citations

Localization of a Repressive Sequence Contributing to B-Cell Specificity in the Immunoglobulin Heavy-Chain Enhancer

1988 • 22 citations

A universally applicable method of isolating somatic cell hybrids by two-colour flow sorting

1981 • 20 citations

Phenotype of hybrids between lymphoid cells and rat hepatoma cells

1982 • 17 citations

Time course of arrest of immunoglobulin expression in heterokaryons and early hybrids of human lymphoma cells and mouse fibroblasts

1985 • 10 citations

Hybridization of a human myeloma permanent cell line with mouse cells

1976 • 8 citations