In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

Rosette-Forming Human Lymphoid Cell Lines. I. Establishment and Evidence for Origin of Thymus-Derived Lymphocytes<xref ref-type="fn" rid="FN1">2</xref>

1972 • 916 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

1981 • 776 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome

1984 • 674 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

Multiple sequence motifs are involved in SV40 enhancer function.

1986 • 511 citations

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1984 • 458 citations

An EBV-Genome-Negative Cell Line Established from an American Burkitt Lymphoma; Receptor Characteristics. EBV Infectibility and Permanent Conversion into EBV-Positive Sublines by <i>in vitro</i> Infection

1975 • 434 citations

A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene

1984 • 410 citations

Murine B Cell Leukemia Line with Inducible Surface Immunoglobulin Expression

1978 • 388 citations

Specific interaction between enhancer-containing molecules and cellular components

1984 • 374 citations

Purification of nuclear factor I by DNA recognition site affinity chromatography.

1986 • 331 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences

1986 • 298 citations

The SV40 enhancer is composed of multiple functional elements that can compensate for one another

1986 • 293 citations

Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors

1985 • 271 citations

The SV40 enhancer can be dissected into multiple segments, each with a different cell type specificity.

1987 • 265 citations

Nuclear factor III, a novel sequence-specific DNA-binding protein from HeLa cells stimulating adenovirus DNA replication

1986 • 256 citations

An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes

1985 • 250 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

Discrete elements within the SV40 enhancer region display different cell-specific enhancer activities.

1987 • 240 citations

Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts

1986 • 209 citations

Structure of two forms of the interferon-induced (2′-5′) oligo A synthetase of human cells based on cDNAs and gene sequences.

1985 • 201 citations

Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) genes.

1986 • 201 citations

Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor.

1984 • 199 citations

A dimer of AraC protein contacts three adjacent major groove regions of the araI DNA site.

1985 • 197 citations

Two regulatory elements for immunoglobulin kappa light chain gene expression.

1984 • 197 citations

Sequence-specific interactions between cellular DNA-binding proteins and the adenovirus origin of DNA replication.

1987 • 169 citations

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

1983 • 165 citations

A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes

1987 • 160 citations

Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B gene.

1986 • 157 citations

Fine mapping of an immunoglobulin gene activator.

1984 • 144 citations

The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells.

1986 • 140 citations

Specific protein binding to the simian virus 40 enhancer in vitro.

1986 • 135 citations

Promoter Elements of Genes Coding for Proteins and Modulation of Transcription by Estrogens and Progesterone

1984 • 133 citations

The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer

1987 • 129 citations

Cell-type preference of immunoglobulin kappa and lambda gene promoters.

1985 • 118 citations

The mouse immunoglobulin heavy-chain enhancer: effect on transcription in vitro and binding of proteins present in HeLa and lymphoid B cell extracts.

1986 • 114 citations

In Vivo Competition Between a Metallothionein Regulatory Element and the SV40 Enhancer

1986 • 106 citations

During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation

1986 • 105 citations

Oligonucleotide-directed mutagenesis by microscale ‘shot-gun’ gene synthesis

1985 • 105 citations

The Immunoglobulin Octanucleotide: Independent Activity and Selective Interaction with Enhancers

1987 • 97 citations

Cell-type-specific transcription of an immunoglobulin kappa light chain gene in vitro.

1986 • 96 citations

Functional domains of the yeast regulatory protein GAL4.

1986 • 95 citations

Mutational analysis of the immunoglobulin heavy chain promoter region.

1986 • 94 citations

Human U2 and U1 RNA genes use similar transcription signals.

1984 • 91 citations

Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements.

1986 • 73 citations

Multiple Sequence Elements Are Required for Maximal in Vitro Transcription of a Human Histone H2B Gene

1986 • 73 citations

Sequence-Specific Interactions Between Cellular DNA-Binding Proteins and the Adenovirus origin of DNA Replication

1987 • 73 citations

Magic Enhancers?

1984 • 70 citations

Specific Protein Binding to the Simian Virus 40 Enhancer in Vitro

1986 • 68 citations

Maximizing gene expression

1987 • 63 citations

Characterization of Productive and Sterile Transcripts from the Immunoglobulin Heavy-Chain Locus: Processing of μ_m and μ_s mRNA

1983 • 63 citations

Regulation of eukaryotic gene expression by transactivating proteins and cis acting DNA elements

1984 • 59 citations

Upstream regulatory sequences of immunoglobulin genes are recognized by nuclear proteins which also bind to other gene regions

1986 • 42 citations

Nuclear factors bind to regulatory regions of the mouse kappa immunoglobulin gene

1986 • 40 citations

Characterization of Two Nonallelic Pairs of Late Histone H2A and H2B Genes of the Sea Urchin: Differential Regulation in the Embryo and Tissue-Specific Expression in the Adult

1986 • 35 citations

Viral and cellular transcription enhancers.

1985 • 22 citations