The conserved decanucleotide from the immunoglobulin heavy chain promoter induces a very high transcriptional activity in B-cells when introduced into an heterologous promoter.

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

1985 • 1,248 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

1984 • 891 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Enhancer elements

1983 • 576 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

POSITIVE CONTROL OF TRANSCRIPTION INITIATION IN BACTERIA

1984 • 369 citations

A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells

1984 • 365 citations

Compilation and analysis of eukaryotic POL II promoter sequences

1986 • 345 citations

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter

1986 • 336 citations

Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence

1985 • 313 citations

Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences

1986 • 298 citations

An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes

1985 • 250 citations

Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts

1986 • 209 citations

Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells.

1986 • 178 citations

Distinct factors bind to apparently homolgous sequences in the immunoglobulin heavy-chain enhancer

1986 • 161 citations

Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B gene.

1986 • 157 citations

Upstream sequences required for tissue-specific activation of the cardiac actin gene in Xenopus laevis embryos.

1986 • 144 citations

The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells.

1986 • 140 citations

Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells.

1987 • 138 citations

Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors.

1985 • 127 citations

Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity

1986 • 123 citations

The mouse immunoglobulin heavy-chain enhancer: effect on transcription in vitro and binding of proteins present in HeLa and lymphoid B cell extracts.

1986 • 114 citations

The two embryonic U1 RNA genes of Xenopus laevis have both common and gene-specific transcription signals.

1985 • 114 citations

Cell type-specific negative regulatory element in the control region of the rat alpha-fetoprotein gene.

1986 • 113 citations

Repression mediates cell-type-specific expression of the rat growth hormone gene.

1986 • 99 citations

Mechanisms that Regulate Immunoglobulin Gene Expression

1985 • 97 citations

Cell-type-specific transcription of an immunoglobulin kappa light chain gene in vitro.

1986 • 96 citations

Mutational analysis of the immunoglobulin heavy chain promoter region.

1986 • 94 citations

Transcription signals in embryonic Xenopus laevis U1 RNA genes.

1985 • 91 citations

Ren-1 and Ren-2 loci are expressed in mouse kidney.

1985 • 88 citations

Sequences closely related to an immunoglobulin gene promoter/enhancer element occur also upstream of other eukaryotic and of prokaryotic genes

1986 • 78 citations

Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements.

1986 • 73 citations

Multiple Sequence Elements Are Required for Maximal in Vitro Transcription of a Human Histone H2B Gene

1986 • 73 citations

Expression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative analysis of 5'-proximal flanking regions.

1984 • 61 citations

Trans-acting nuclear protein responsible for induction of rearranged human immunoglobulin heavy chain gene

1986 • 46 citations

Upstream regulatory sequences of immunoglobulin genes are recognized by nuclear proteins which also bind to other gene regions

1986 • 42 citations

Mouse kidney and submaxillary gland renin genes differ in their 5' putative regulatory sequences.

1984 • 42 citations

Nuclear factors bind to regulatory regions of the mouse kappa immunoglobulin gene

1986 • 40 citations

Cell‐Type Specific Regulation of a K Immunoglobulin Gene by Promoter and Enhancer Elements

1986 • 21 citations

Analysis of promoter and enhancer cell type specificities and the regulation of immunoglobulin gene expression

1986 • 14 citations

Expression of Tissue-Specific Ren-1 and Ren-2 Genes of Mice: Comparative Analysis of 5′-Proximal Flanking Regions

1984 • 14 citations