Role of the octamer motif in hybrid cell extinction of immunoglobulin gene expression: Extinction is dominant in a two enhancer system

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

1988 • 494 citations

Immunoglobulin gene expression in transformed lymphoid cells.

1983 • 400 citations

A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

1988 • 399 citations

Cell-type-specific contacts to immunoglobulin enhancers in nuclei

1985 • 341 citations

Deletion mapping of DNA regions required for SV40 early region promoter function in vivo.

1982 • 328 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells

1978 • 324 citations

Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA Motif

1988 • 304 citations

A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells

1987 • 301 citations

The SV40 enhancer can be dissected into multiple segments, each with a different cell type specificity.

1987 • 265 citations

A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae.

1987 • 262 citations

Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.

1987 • 255 citations

5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains

1980 • 238 citations

Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.

1987 • 218 citations

Complementation Patterns of Thy-1 Variants and Evidence That Antigen Loss Variants “Pre-Exist” in the Parental Population 2

1974 • 204 citations

Analysis of the role of the transcription factor ATF in the assembly of a functional preinitiation complex

1988 • 180 citations

In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers.

1987 • 149 citations

Regulatory Circuits for Gene Expression: The Metabolism of Galactose and Phosphate

1982 • 141 citations

Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity

1986 • 123 citations

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

1987 • 113 citations

Interaction of a tissue-specific factor with an essential rat growth hormone gene promoter element.

1987 • 89 citations

Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1

1988 • 88 citations

Two Mechanisms for the Extinction of Gene Expression in Hybrid Cells

1988 • 73 citations

Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer.

1988 • 53 citations

Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line.

1988 • 52 citations

DNA rearrangements in MPC-11 immunoglobulin heavy chain class-switch variants.

1982 • 39 citations

Both immunoglobulin promoter and enhancer sequences are targets for suppression in myeloma-fibroblast hybrid cells.

1988 • 34 citations

DNA rearrangement causes a high rate of spontaneous mutation at the immunoglobulin heavy-chain locus of a mouse myeloma cell line.

1986 • 15 citations