Imprinting mechanisms in mammals

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

Epigenetic mechanisms of gene regulation

1996 • 1,097 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15

1995 • 606 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

How does DNA methylation repress transcription?

1997 • 532 citations

Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons

1997 • 495 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells

1997 • 469 citations

Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region

1994 • 430 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

An enhancer deletion affects both H19 and Igf2 expression.

1995 • 398 citations

Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements

1997 • 354 citations

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

1993 • 345 citations

A 5′ 2-Kilobase-Pair Region of the Imprinted Mouse H19 Gene Exhibits Exclusive Paternal Methylation throughout Development

1997 • 341 citations

Transactivation of Igf2 in a mouse model of Beckwith–Wiedemann syndrome

1997 • 325 citations

A 450 kb Transgene Displays Properties of the Mammalian X-Inactivation Center

1996 • 315 citations

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.

1992 • 279 citations

Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes

1994 • 277 citations

Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes.

1996 • 271 citations

Long-range cis effects of ectopic X-inactivation centres on a mouse autosome

1997 • 268 citations

Biallelic expression of imprinted genes in the mouse germ line: implications for erasure, establishment, and mechanisms of genomic imprinting.

1995 • 263 citations

Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene

1996 • 257 citations

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.

1996 • 254 citations

Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2

1997 • 248 citations

Xist has properties of the X-chromosome inactivation centre

1997 • 248 citations

Evidence that random and imprinted Xist expression is controlled by preemptive methylation

1994 • 247 citations

Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element.

1997 • 243 citations

Homologous Association of Oppositely Imprinted Chromosomal Domains

1996 • 238 citations

Gene structure, DNA methylation, and imprinted expression of the human SNRPN gene.

1996 • 234 citations

Identification of an imprinted U2af binding protein related sequence on mouse chromosome 11 using the RLGS method

1994 • 219 citations

Imprinting mutations suggested by abnormal DNA methylation patterns in familial Angelman and Prader-Willi syndromes.

1994 • 219 citations

Imprinting mutations in the Beckwith—Wiedemann syndrome suggested by an altered imprinting pattern in the IGF2–H19 domain

1995 • 215 citations

Parental imprinting of autosomal mammalian genes

1994 • 208 citations

Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern

1997 • 195 citations

DNA Demethylation In Vitro: Involvement of RNA

1996 • 188 citations

Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching.

1993 • 170 citations

PARENTAL IMPRINTING AND HUMAN DISEASE

1996 • 170 citations

Human PEG1/MEST, an Imprinted Gene on Chromosome 7

1997 • 158 citations

Methylation of the mouse Xist gene in sperm and eggs correlates with imprinted Xist expression and paternal X–inactivation

1995 • 155 citations

Production of Androgenetic Zebrafish (Danio rerio)

1996 • 139 citations

Interchromosomal Transfer of Epigenetic States in Ascobolus: Transfer of DNA Methylation Is Mechanistically Related to Homologous Recombination

1996 • 132 citations

Imprinted chromosomal regions of the human genome display sex-specific meiotic recombination frequencies

1995 • 129 citations

Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway

1996 • 127 citations

Conservation of a maternal-specific methylation signal at the human IGF2R locus

1995 • 116 citations

Competition- a common motif for the imprinting mechanism?

1997 • 115 citations

Formation of methylation patterns in the mammalian genome

1997 • 114 citations

Gamete–specific methylation correlates with imprinting of the murine Xist gene

1995 • 113 citations

Sex-specific meiotic recombination in the Prader--Willi/Angelman syndrome imprinted region

1995 • 110 citations

Imprinting of Igf2 and H19 from a 130 kb YAC transgene

1997 • 108 citations

An imprinting element from the mouse H19 locus functions as a silencer in Drosophila

1997 • 106 citations

An Imprinted Mouse Transcript Homologous to the Human Imprinted in Prader-Willi Syndrome (IPW) Gene

1997 • 105 citations

Loss of the maternal H19 gene induces changes in Igf 2 methylation in both cis and trans

1997 • 105 citations

The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns

1998 • 101 citations

A new imprinted gene cloned by a methylation-sensitive genome scanning method

1993 • 100 citations

Monoallelic Expression of HumanPEG1/MESTIs Paralleled by Parent-Specific Methylation in Fetuses

1997 • 96 citations

The structural H19 gene is required for transgene imprinting

1996 • 95 citations

Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus

1996 • 93 citations

Genomic imprinting: causes and consequences.

1995 • 91 citations

Imprinted genes and regulation of gene expression by epigenetic inheritance

1996 • 88 citations

Allelic methylation of H19 and IGF2 in the Beckwith — Wiedemann syndrome

1994 • 87 citations

Genomic Structure and Parent-of-Origin-Specific Methylation of Peg1

1997 • 85 citations

Dynamic methylation adjustment and counting as part of imprinting mechanisms.

1996 • 81 citations

A 5′ Differentially Methylated Sequence and the 3′-Flanking Region Are Necessary for H19 Transgene Imprinting

1997 • 77 citations

Maternal-Specific Methylation of the HumanIGF2RGene Is Not Accompanied by Allele-Specific Transcription

1996 • 70 citations

Regulation of genomic imprinting by gametic and embryonic processes.

1995 • 67 citations

Multiple roles for DNA methylation in gametic imprinting

1996 • 66 citations

Different Mechanisms and Recurrence Risks of Imprinting Defects in Angelman Syndrome

1997 • 65 citations

Imprinting at the MouseIns2Locus: Evidence forcis- andtrans-Allelic Interactions

1998 • 56 citations

DNA methylation in genomic imprinting

1997 • 54 citations

Genomic Imprinting in Mice: Its Function and Mechanism1

1996 • 54 citations

Allele-specific methylation and expression of an imprinted U2afl-rsl (SP2) gene

1995 • 53 citations

Genomic Imprinting: A Chromatin Connection

1997 • 52 citations

Polymorphic Functional Imprinting of the Human IGF2 Gene among Individuals, in Blood Cells, Is Associated with H19 Expression

1996 • 51 citations

Genomic Imprinting and Chromosomal Localization of the HumanMESTGene

1996 • 50 citations

Parental Chromosome-specific Chromatin Conformation in the Imprinted U2af1-rs1 Gene in the Mouse

1997 • 48 citations

Imprinting mutations on human chromosome 15

1997 • 47 citations

Developmental Regulation of Genomic Imprinting during Gametogenesis

1995 • 45 citations

Genomic Deletion of an Imprint Maintenance Element Abolishes Imprinting of Both Insulin-like Growth Factor II andH19

1997 • 44 citations

Identification of a silencing element in the human 15q11-q13 imprinting center by using transgenicDrosophila

1998 • 38 citations

Aberrant Methylation of an Imprinted Gene U2af1-rs1(SP2) Caused by Its Own Transgene

1997 • 36 citations

Parental imprinting of an IGF‐2 transgene

1993 • 34 citations

An Oocyte-Specific Methylation Imprint Center in the MouseU2afbp-rs/U2af1-rs1Gene Marks the Establishment of Allele-Specific Methylation during Preimplantation Development

1997 • 24 citations

A male-specific nuclease-resistant chromatin fraction in the mealybug Planococcus lilacinus

1996 • 21 citations

Genomic regions regulating imprinting and insulin‐like growth factor‐II promoter 3 activity in transgenics: novel enhancer and silencer elements

1997 • 19 citations

The Wellcome Prize Lecture. Genetic imprinting: the battle of the sexes rages on

1996 • 19 citations

Imprinted Genes Are Up-Regulated by Growth Arrest in Embryonic Fibroblasts

1997 • 18 citations

Maternal and paternal genomes function independently in mouse ova in establishing expression of the imprinted genes Snrpn and Igf2r: no evidence for allelic trans-sensing and counting mechanisms.

1996 • 16 citations

Imprint switch mechanism indicated by mutations in prader-willi and angelman syndromes

1997 • 13 citations

Establishment of Imprinted Methylation Patterns during Development

1996 • 11 citations

Convergent themes in X chromosome inactivation and autosomal imprinting

1997 • 10 citations

Genomic Imprinting and Modifier Genes in the Mouse

1996 • 8 citations

Genomic imprinting of chromatin inDrosophila melanogaster

1996 • 7 citations

Panning for gold at the K stream

1997 • 3 citations

Genomic imprinting as a developmental process disturbed in cancer

1997 • 1 citations