Principles for Adoptive T Cell Therapy of Human Viral Diseases

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Human gene therapy comes of age

1992 • 927 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

Virus-specific CD8+ T-cell memory determined by clonal burst size

1994 • 525 citations

The Biochemistry, Biology, and Role of Interleukin 2 in the Induction of Cytotoxic T Cell and Antibody-Forming B Cell Responses

1982 • 524 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies.

1992 • 519 citations

Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones.

1986 • 513 citations

Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus.

1988 • 462 citations

B–cell memory is short-lived in the absence of antigen

1988 • 430 citations

Cytokine-mediated regulation of chronic intestinal helminth infection.

1994 • 425 citations

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

1991 • 419 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 • 372 citations

Identification of the major late human cytomegalovirus matrix protein pp65 as a target antigen for CD8⁺ virus‐specific cytotoxic T lymphocytes

1994 • 359 citations

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

1994 • 321 citations

Distinct types of lung disease caused by functional subsets of antiviral T cells.

1994 • 318 citations

Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus

1992 • 303 citations

The SCID-hu mouse as a model for HIV-1 infection

1993 • 288 citations

Human herpesviruses: a consideration of the latent state

1989 • 279 citations

Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2.

1982 • 267 citations

Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse.

1993 • 265 citations

Response to influenza infection in mice with a targeted disruption in the interferon gamma gene.

1993 • 247 citations

Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands

1992 • 243 citations

Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells.

1991 • 241 citations

Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.

1989 • 241 citations

Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.

1990 • 240 citations

Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells.

1992 • 237 citations

Different Roles for L3T4+ and Lyt 2+ T Cell Subsets in the Control of an Acute Herpes Simplex Virus Infection of the Skin and Nervous System

1987 • 236 citations

Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression.

1991 • 235 citations

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment.

1992 • 204 citations

Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells

1992 • 201 citations

Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell function.

1991 • 195 citations

The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen.

1994 • 190 citations

Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

1993 • 150 citations

Protection of Mice from Fatal Herpes Simplex Virus Type 1 Infection by Adoptive Transfer of Cloned Virus-specific and H-2-restricted Cytotoxic T Lymphocytes

1983 • 149 citations

Acquisition of specific cytotoxic activity by human T4+ T lymphocytes in culture

1984 • 147 citations

Theiler's virus infection of beta 2-microglobulin-deficient mice

1993 • 141 citations

Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus

1986 • 138 citations

Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions

1994 • 134 citations

Selective interference with class I major histocompatibility complex presentation of the major immediate-early protein following infection with human cytomegalovirus

1993 • 119 citations

Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes.

1991 • 117 citations

Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase

1989 • 115 citations

Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen.

1994 • 113 citations

MHC Class I-Deficient Mice

1993 • 112 citations

Resistance of Mice Deficient in IL-4 to Retrovirus-Induced Immunodeficiency Syndrome (MAIDS)

1993 • 112 citations

Mouse anti-adenovirus cytotoxic T lymphocytes. Inhibition of lysis by E3 gp19K but not E3 14.7K.

1989 • 105 citations

The amino-terminal helix of GM-CSF and IL-5 governs high affinity binding to their receptors.

1991 • 103 citations

Peripheral clonal deletion of antiviral memory CD8⁺ T cells

1993 • 96 citations

Rapid recovery of lung histology correlates with clearance of influenza virus by specific CD8+ cytotoxic T cells.

1989 • 91 citations

Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals: Gag epitopes are clustered in three regions of the p24gag protein

1993 • 86 citations

Prolonged immunostimulatory effect of low-dose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection.

1993 • 82 citations

Downregulation of peptide transporter genes in cell lines transformed with the highly oncogenic adenovirus 12.

1994 • 75 citations

Effect of T-cell receptor antagonism on interaction between T cells and antigen-presenting cells and on T-cell signaling events.

1993 • 74 citations

Mutation of human immunodeficiency virus type 1 at amino acid 585 on gp41 results in loss of killing by CD8+ A24-restricted cytotoxic T lymphocytes

1992 • 73 citations

Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient mice.

1993 • 67 citations

Immortalizing Genes of Epstein-Barr Virus

1991 • 64 citations

Identification of enhancer-like elements in human IFN-gamma genomic DNA.

1990 • 61 citations

Two subpopulations of human triple-negative thymic cells are susceptible to infection by human immunodeficiency virus type 1 in vitro

1994 • 55 citations

Borna disease virus-specific T cells protect against or cause immunopathological Borna disease.

1994 • 49 citations

Recognition of a Single hsp‐60 Epitope by an Entire Subset of γδ T Lymphocytes

1991 • 43 citations

Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice.

1993 • 40 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. VI. Migration and activity in vivo in acute and persistent infection.

1986 • 27 citations

Virus-specific cytotoxic T cell-mediated lysis of lymphocytes in vitro and in vivo.

1993 • 21 citations