Activation of the serum response factor by p65/NF-kappaB.

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

1992 • 632 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Structure of the NF-κB p50 homodimer bound to DNA

1995 • 525 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

The serum response element

1992 • 458 citations

Isolation of a rel -related Human cDNAThat Potentially Encodes the 65-kD Subunit of NF-κB

1991 • 448 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

1993 • 440 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/EBP and NF-κB

1993 • 400 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

Structure of serum response factor core bound to DNA

1995 • 340 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition

1992 • 325 citations

Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

1992 • 314 citations

The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression.

1992 • 288 citations

The SRE: a growth factor responsive transcriptional regulator.

1990 • 287 citations

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.

1992 • 281 citations

Distinct Protein Targets for Signals Acting at the c- fos Serum Response Element

1991 • 244 citations

N- and C-Terminal Sequences Control Degradation of MAD3/IκBα in Response to Inducers of NF-κB Activity

1995 • 227 citations

Net, a new ets transcription factor that is activated by Ras.

1994 • 216 citations

Calcium Activates Serum Response Factor-Dependent Transcription By A Ras- and Elk-1-Independent Mechanism That Involves a Ca²⁺/Calmodulin-Dependent Kinase

1995 • 215 citations

Functionally Distinct NF-κB Binding Sites in the Immunoglobulin κ and IL-2 Receptor α Chain Genes

1989 • 194 citations

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1994 • 186 citations

Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved protein-binding site.

1987 • 181 citations

The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.

1993 • 177 citations

Spatial flexibility in ternary complexes between SRF and its accessory proteins.

1992 • 175 citations

Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain.

1994 • 162 citations

c-fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF.

1993 • 153 citations

The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1.

1994 • 145 citations

Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor.

1994 • 142 citations

A protein domain conserved between yeast MCM1 and human SRF directs ternary complex formation.

1991 • 140 citations

Elk-1 protein domains required for direct and SRF-assisted DNA-binding

1992 • 137 citations

Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties.

1992 • 132 citations

NFκB and Interferon Regulatory Factor 1 Physically Interact and Synergistically Induce Major Histocompatibility Class I Gene Expression

1995 • 121 citations

Identification of transcriptional activation and inhibitory domains in serum response factor (SRF) by using GAL4-SRF constructs.

1993 • 120 citations

DNA binding-induced conformational change of the yeast transcriptional activator PRTF

1990 • 119 citations

Functional and Physical Associations between NF-κB and C/EBP Family Members: a Rel Domain-bZIP Interaction

1993 • 112 citations

Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.

1994 • 104 citations

Ternary complex formation over the c-fos serum response element: p62TCF exhibits dual component specificity with contacts to DNA and an extended structure in the DNA-binding domain of p67SRF.

1992 • 94 citations

Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B.

1994 • 92 citations

Functional dissection of the transcription factor Elk-1.

1994 • 90 citations

Promoter function and structure of the growth factorinducible immediate early genecyr61

1991 • 87 citations

Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel.

1992 • 87 citations

A Novel Mitogen-Inducible Gene Product Related to p50/pl05- NF-κB Participates in Transactivation through a κB Site

1992 • 77 citations

Cell-type specific multiprotein complex formation over the c-fosserum response elementin vivo: ternary complex formation is not required for the induction of c-fos

1991 • 73 citations

MCM1 point mutants deficient in expression of alpha-specific genes: residues important for interaction with alpha 1.

1994 • 61 citations

The Transcription Factors Elk-1 and Serum Response Factor Interact by Direct Protein-Protein Contacts Mediated by a Short Region of Elk-1

1994 • 57 citations

Mutational analysis of the p50 subunit of NF-kappa B and inhibition of NF-kappa B activity by trans-dominant p50 mutants

1993 • 57 citations

Activation of the interleukin-2 receptor alpha gene: regulatory role for DNA-protein interactions flanking the kappa B enhancer.

1989 • 49 citations

Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes.

1993 • 43 citations

The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.

1990 • 41 citations

Inhibition of v-raf-Dependent c-fos Expression and Transformation by a Kinase-Defective Mutant of the Mitogen-Activated Protein Kinase Erk2

1994 • 41 citations

Two Pathways for Serum Regulation of the c-fos Serum Response Element Require Specific Sequence Elements and a Minimal Domain of Serum Response Factor

1994 • 40 citations

Mutational Analysis of the Transcription Activation Domain of RelA: Identification of a Highly Synergistic Minimal Acidic Activation Module

1994 • 36 citations

elk-1 domains responsible for autonomous DNA binding, SRE:SRF interaction and negative regulation of DNA binding.

1992 • 35 citations

Identification of Transcriptional Activation and Inhibitory Domains in Serum Response Factor (SRF) by Using GAL4-SRF Constructs

1993 • 31 citations

Activation of IL-2 receptor alpha-chain gene by individual members of the rel oncogene family in association with serum response factor.

1995 • 25 citations

κB Site-Dependent Activation of the Interleukin-2 Receptor α-Chain Gene Promoter by Human c-Rel

1992 • 23 citations

Activation of the interleukin-2 receptor alpha gene: regulatory role for DNA-protein interactions flanking the kappa B enhancer.

1989 • 20 citations

Interaction Between Nf-κB- and Serum Response Factor-Binding Elements Activates an Interleukin-2 Receptor α-Chain Enhancer Specifically in T Lymphocytes

1993 • 11 citations

MCM1 Point Mutants Deficient in Expression of α-Specific Genes: Residues Important for Interaction with α1

1994 • 10 citations