MINIREVIEW: Estrogen Receptor Variants in Clinical Breast Cancer

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

1988 • 636 citations

Variant human breast tumor estrogen receptor with constitutive transcriptional activity.

1991 • 397 citations

Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2.

1987 • 279 citations

Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance

1982 • 249 citations

Estrogen receptor expression in human breast cancer associated with an estrogen receptor gene restriction fragment length polymorphism.

1989 • 145 citations

T47DCO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance.

1990 • 121 citations

Variant Estrogen Receptor mRNA Species Detected in Human Breast Cancer Biopsy Samples

1989 • 111 citations

Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer

1990 • 111 citations

A Variant Estrogen Receptor Messenger Ribonucleic Acid is Associated with Reduced Levels of Estrogen Binding in Human Mammary Tumors

1988 • 108 citations

Truncated forms of DNA-binding estrogen receptors in human breast cancer.

1991 • 104 citations

Human Breast Cancer: Biologically Active Estrogen Receptor in the Absence of Estrogen?

1977 • 86 citations

Characterization of estrogen receptor messenger RNA in human breast cancer.

1987 • 79 citations

PvuII RFLP inside the human estrogen receptor gene

1987 • 78 citations

Genomic DNA analysis of the estrogen receptor gene in breast cancer

1989 • 69 citations

Identification of a variant form of the human estrogen receptor with an amino acid replacement

1989 • 69 citations

Sensitive Detection of Estrogen Receptor RNA by Polymerase Chain Reaction Assay

1990 • 63 citations

Measurement of oestrogen receptor mRNA levels in human breast tumours

1988 • 50 citations

Estrogen receptor gene methylation in human breast tumors.

1990 • 46 citations

Is a functional estrogen receptor always required for progesterone receptor induction in breast cancer?

1981 • 40 citations

Estrogen receptor gene amplification is found in some estrogen receptor-positive human breast tumors

1990 • 36 citations

Estrogen induced increase of estrogen receptor RNA in human breast cancer cells

1988 • 29 citations

A new approach allowing an early prognosis in breast cancer: the ratio of estrogen receptor (ER) ligand binding activity to the ER-specific mRNA level.

1989 • 27 citations

Analysis of the estrogen receptor gene structure in human breast cancer.

1989 • 19 citations

Somatic change in the estrogen receptor gene associated with altered expression of the progesterone receptor.

1991 • 10 citations