Negative Interaction between the RelA(p65) Subunit of NF-κB and the Progesterone Receptor

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

1995 • 1,834 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

1995 • 815 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

Negative effect of the transcriptional activator GAL4

1988 • 672 citations

Progestin Regulation of Cellular Proliferation*

1990 • 659 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

Steroid hormone receptors compete for factors that mediate their enhancer function

1989 • 580 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.

1995 • 487 citations

Isolation of a rel -related Human cDNAThat Potentially Encodes the 65-kD Subunit of NF-κB

1991 • 448 citations

Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.

1994 • 423 citations

Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA

1987 • 419 citations

Interaction of proteins with transcriptionally active estrogen receptors.

1994 • 379 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Progesterone-binding Components of Chick Oviduct

1972 • 372 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

1994 • 307 citations

Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB.

1990 • 290 citations

NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit.

1991 • 287 citations

Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo.

1992 • 282 citations

Human Endometrium: An Active Site of Cytokine Production and Action*

1991 • 274 citations

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

1993 • 268 citations

12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter.

1994 • 266 citations

RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.

1995 • 257 citations

Mitogenic stimulation of human breast cancer cells in a growth factor‐defined medium: Synergistic action of insulin and estrogen

1988 • 245 citations

Hormonal Chemoprevention of Cancer in Women

1993 • 244 citations

Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.

1991 • 195 citations

A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms.

1992 • 171 citations

Immunologic and Endocrine Interrelationships in Pregnancy

1982 • 168 citations

Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies

1987 • 162 citations

Pregnancy Maintenance and Parturition: The Role of Prostaglandin in Manipulating the Immune and Inflammatory Response

1994 • 161 citations

Novel Pathway for Thyroid Hormone Receptor Action through Interaction with jun and fos Oncogene Activities

1991 • 154 citations

Direct effects of estrogen on c-fos and c-myc protooncogene expression and cellular proliferation in human breast cancer cells

1989 • 122 citations

Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.

1992 • 119 citations

Suppression of interleukin 8 production by progesterone in rabbit uterine cervix

1994 • 112 citations

Identification of a Naturally Occurring Transforming Variant of the p65 Subunit of NF-κB

1992 • 105 citations

Polymorphisms in the coding and noncoding regions of murinePgk-1 alleles

1990 • 95 citations

Inhibition of Estrogen Receptor Activity by the Tumor Promoter 12-O-Tetradeconylphorbol-13-Acetate: A Molecular Analysis

1991 • 94 citations

Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody.

1992 • 81 citations

[26] Nuclear retinoic acid receptors: Cloning, analysis, and function

1990 • 73 citations

Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro.

1992 • 69 citations

Clonal heterogeneity in colony stimulating factor production by murine T lymphocytes

1985 • 65 citations

Synthetic progestins induce proliferation of breast tumor cell lines via the progesterone or estrogen receptor

1994 • 63 citations

Disruption of I kappa B alpha regulation by antisense RNA expression leads to malignant transformation.

1994 • 60 citations

Implantation: Tumour necrosis factor α inhibits in-vitro decidualization of human endometrial stromal cells

1994 • 53 citations

Tumor necrosis factor-alpha inhibits the synthesis and release of human decidual prolactin.

1994 • 47 citations

Cloning of cDNA sequences of a progestin-regulated mRNA from MCF7 human breast cancer cells

1986 • 36 citations

Transformation by the vRel oncoprotein requires sequences carboxy-terminal to the Rel homology domain.

1993 • 35 citations

Two novel functions associated with the Rel oncoproteins: DNA replication and cell-specific transcriptional activation.

1993 • 27 citations