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TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

1993 • 1,122 citations

Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy

1999 • 1,100 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

Maternal Intrauterine Infection, Cytokines, and Brain Damage in the Preterm Newborn

1997 • 898 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

DNA–based immunization by in vivo transfection of dendritic cells

1996 • 849 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin

1992 • 810 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

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PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR I<scp>G</scp>A-PRODUCING IMMUNOCYTES IN THE RABBIT

1971 • 756 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Expression of hepatitis B surface antigen in transgenic plants.

1992 • 711 citations

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

1993 • 655 citations

Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.

1992 • 641 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

The role of nasopharyngeal lymphoid tissue

1992 • 532 citations

Role of NK1.1 ⁺ T Cells in a T _H 2 Response and in Immunoglobulin E Production

1995 • 508 citations

Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice.

1991 • 499 citations

Dendritic Cell Vaccines for Cancer Immunotherapy

1999 • 497 citations

Protective Effect of Rotavirus VP6-Specific IgA Monoclonal Antibodies That Lack Neutralizing Activity

1996 • 487 citations

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

1998 • 480 citations

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

1992 • 480 citations

Adenoviruses as Gene-Delivery Vehicles

1996 • 480 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Expression of rabies virus glycoprotein from a recombinant vaccinia virus

1984 • 448 citations

Replicon-Helper Systems from Attenuated Venezuelan Equine Encephalitis Virus: Expression of Heterologous Genesin Vitroand Immunization against Heterologous Pathogensin Vivo

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Intracellular neutralization of virus by immunoglobulin A antibodies.

1992 • 438 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Systemic tolerance and secretory immunity after oral immunization.

1980 • 432 citations

Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens.

1986 • 428 citations

The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions.

1978 • 422 citations

Oral Somatic Transgene Vaccination Using Attenuated S. typhimurium

1997 • 409 citations

Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus.

1993 • 397 citations

Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.

1995 • 392 citations

CpG DNA Induces Sustained IL-12 Expression In Vivo and Resistance toListeria monocytogenesChallenge

1998 • 383 citations

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 • 381 citations

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 • 372 citations

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin.

1992 • 369 citations

DNA Vaccination: Transfection and Activation of Dendritic Cells as Key Events for Immunity

1999 • 367 citations

Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity

1995 • 353 citations

Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function.

1990 • 349 citations

Applications of pox virus vectors to vaccination: an update.

1996 • 348 citations

Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells.

1990 • 340 citations

Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen.

1984 • 334 citations

Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice.

1993 • 334 citations

Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance

1998 • 327 citations

Antigen Presentation by Dendritic Cells after Immunization with DNA Encoding a Major Histocompatibility Complex Class II–restricted Viral Epitope

1997 • 326 citations

Cross‐protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity

1984 • 320 citations

CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus

1998 • 318 citations

Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance.

1994 • 317 citations

Role of J Chain and Secretory Component in Receptor‐Mediated Glandular and Hepatic Transport of Immunoglobulins in Man

1985 • 312 citations

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

1997 • 305 citations

Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches

1998 • 301 citations

Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women

1997 • 292 citations

A recombinant vector derived from the host range-restricted and highly attenuated MVA strain of vaccinia virus stimulates protective immunity in mice to influenza virus

1994 • 291 citations

Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine

1991 • 290 citations

Role of Cytokines in the Differentiation of CD4⁺ T‐Cell Subsets in vivo

1991 • 289 citations

Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants.

1995 • 288 citations

The adjuvant effect of Vibrio cholerae and Escherichia coli heat‐labile enterotoxins is linked to their ADP‐ribosyltransferase activity

1992 • 286 citations

Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens

1988 • 283 citations

A plant-based cholera toxin B subunit–insulin fusion protein protects against the development of autoimmune diabetes

1998 • 278 citations

Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens.

1997 • 278 citations

Regulation of IgA synthesis and immune response by T cells and interleukins

1989 • 278 citations

The development of immunoglobulinlevels in man

1968 • 276 citations

Comparison of the carbohydrate-binding specificities of cholera toxin and Escherichia coli heat-labile enterotoxins LTh-I, LT-IIa, and LT-IIb

1988 • 269 citations

Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge

1998 • 265 citations

IgA antibody-producing cells in peripheral blood after antigen ingestion: evidence for a common mucosal immune system in humans.

1987 • 264 citations

Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.

1987 • 259 citations

Resistance to Leishmania major Induced by Tolerance to a Single Antigen

1996 • 258 citations

Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.

1996 • 256 citations

Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL.

1997 • 256 citations

Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina

1997 • 256 citations

Organ and Isotype Distribution of Plasma Cells Producing Specific Antibody after Oral Immunization: Evidence for A Generalized Secretory Immune System

1979 • 254 citations

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

1989 • 252 citations

Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces

1994 • 250 citations

Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation.

1990 • 238 citations

Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization.

1996 • 237 citations

Protective Immunity Induced by Oral Immunization with a Rotavirus DNA Vaccine Encapsulated in Microparticles

1998 • 233 citations

Distribution of IgA1-, IgA2-, and J chain-containing cells in human tissues.

1984 • 232 citations

Transforming growth factor-beta directs IgA switching in human B cells.

1992 • 232 citations

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

1997 • 231 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Specific Immune Induction Following DNA-Based Immunization Through In Vivo Transfection and Activation of Macrophages/Antigen-Presenting Cells

1998 • 223 citations

Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses.

1997 • 222 citations

Role of B cells and cytotoxic T lymphocytes in clearance of and immunity to rotavirus infection in mice

1995 • 215 citations

Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization

1997 • 215 citations

Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL.

1997 • 215 citations

Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells.

1990 • 213 citations

Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant

1996 • 211 citations

Oral vaccination. Identification of classes of proteins that provoke an immune response upon oral feeding.

1988 • 211 citations

Effect of Tonsillectomy and Adenoidectomy on Nasopharyngeal Antibody Response to Poliovirus

1971 • 210 citations

Mutants in the ADP-ribosyltransferase Cleft of Cholera Toxin Lack Diarrheagenicity but Retain Adjuvanticity

1997 • 209 citations

Local Antibody Response to Poliovaccine in the Human Female Genital Tract

1973 • 203 citations

Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit.

1996 • 198 citations

Cholera toxin B subunit as a carrier protein to stimulate a mucosal immune response.

1984 • 196 citations

A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.

1987 • 196 citations

Lymphoglandular complexes of the colon: structure and distribution

1986 • 196 citations

Vaccination against Chlamydial Genital Tract Infection after Immunization with Dendritic Cells Pulsed Ex Vivo with Nonviable Chlamydiae

1998 • 194 citations

Differential cytokine expression in acute and chronic murine graft‐versus‐host‐disease

1993 • 194 citations

Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin.

1994 • 192 citations

Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the Cholera toxin B subunit

1996 • 191 citations

Oral Salmonella typhimurium (AroA-) vaccine expressing a major leishmanial surface protein (gp63) preferentially induces T helper 1 cells and protective immunity against leishmaniasis.

1990 • 188 citations

Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses

1996 • 181 citations

Human immune responses to influenza virus vaccines administered by systemic or mucosal routes

1995 • 180 citations

Gene Transfer in Dendritic Cells, Induced by Oral DNA Vaccination With Salmonellatyphimurium, Results in Protective Immunity Against a Murine Fibrosarcoma

1998 • 180 citations

A recombinant Salmonella typhimurium vaccine induces local immunity by four different routes of immunization

1995 • 179 citations

Mechanisms for Mucosal Immunogenicity and Adjuvancy of Escherichia coli Labile Enterotoxin

1996 • 173 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein

1990 • 164 citations

Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations.

1988 • 164 citations

Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.

1989 • 161 citations

HIV-1 Induces Cytotoxic T Lymphocytes in the Cervix of Infected Women

1997 • 158 citations

Inactivated influenza virus, when presented on dendritic cells, elicits human CD8+ cytolytic T cell responses.

1995 • 157 citations

Immunology of the lung and upper respiratory tract

1985 • 156 citations

Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2/B subunits.

1995 • 156 citations

Novel Delivery Systems for Oral Vaccines

1994 • 155 citations

Antibodies and Antibody-Secreting Cells in the Female Genital Tract after Vaginal or Intranasal Immunization with Cholera Toxin B Subunit or Conjugates

1998 • 154 citations

Secretory immune system of the female reproductive tract: I. Immunoglobulin and secretory component‐containing cells

1989 • 153 citations

Specific secretory immune responses in the female genital tract following intranasal immunization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus

1995 • 153 citations

Induction of compartmentalized B-cell responses in human tonsils

1995 • 149 citations

A Recombinant Human Adenovirus Vaccine against Rabies

1990 • 145 citations

Is BALT a major component of the human lung immune system?

1992 • 145 citations

Bone Marrow‐Derived Dendritic Cells Serve as Potent Adjuvants for Peptide‐Based Antitumor Vaccines

1997 • 144 citations

Langerhans' cells and lymphocyte subsets in the female genita1 tract.

1985 • 143 citations

Antibody-producing cells in peripheral blood and salivary glands after oral cholera vaccination of humans

1991 • 142 citations

Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A).

1996 • 142 citations

Selective transport of IgA. Cellular and molecular aspects.

1991 • 139 citations

Mucosal Immunity and Protection after Intranasal Immunization with Recombinant Adenovirus Expressing Herpes Simplex Virus Glycoprotein B

1993 • 136 citations

Isotype specificity of helper T cell clones. Peyer's patch Th cells preferentially collaborate with mature IgA B cells for IgA responses.

1984 • 136 citations

Migration and homing of lymphoid cells

1988 • 136 citations

Long‐Term Immunity and Protection against Herpes Simplex Virus Type 2 in the Murine Female Genital Tract after Mucosal but Not Systemic Immunization

1998 • 136 citations

Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239

1997 • 135 citations

Transforming growth factor-beta 1 is a costimulator for IgA production.

1990 • 134 citations

Intranasal Immunization with Plasmid DNA-Lipid Complexes Elicits Mucosal Immunity in the Female Genital and Rectal Tracts

1999 • 134 citations

Murine Peyer's patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses.

1982 • 133 citations

Salmonella typhi Vaccine Strain CVD 908 Expressing the Circumsporozoite Protein of Plasmodium falciparum: Strain Construction and Safety and Immunogenicity in Humans

1994 • 132 citations

Vaccine-Containing Biodegradable Microspheres Specifically Enter the Gut-Associated Lymphoid Tissue Following Oral Administration and Induce a Disseminated Mucosal Immune Response

1989 • 132 citations

An adenovirus-simian immunodeficiency virus env vaccine elicits humoral, cellular, and mucosal immune responses in rhesus macaques and decreases viral burden following vaginal challenge

1997 • 131 citations

Dendritic cells and tolerance induction

1996 • 128 citations

Use of Human Adenovirus-based Vectors for Antigen Expression in Animals

1989 • 122 citations

Humoral, mucosal, and cellular immunity in response to a human immunodeficiency virus type 1 immunogen expressed by a Venezuelan equine encephalitis virus vaccine vector

1997 • 121 citations

The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant

1991 • 120 citations

Antiviral cytotoxic T lymphocytes in vaginal mucosa of simian immunodeficiency virus-infected rhesus macaques.

1995 • 119 citations

Human intestinal mononuclear cells. I. Investigation of antibody-dependent, lectin-induced, and spontaneous cell-mediated cytotoxic capabilities.

1980 • 118 citations

Gut mucosal immunization with reovirus serotype 1/L stimulates virus-specific cytotoxic T cell precursors as well as IgA memory cells in Peyer's patches.

1987 • 117 citations

Antibody-secreting cells in the evaluation of the immunogenicity of an oral vaccine

1990 • 117 citations

Leukocytes in the intestinal epithelium: an unusual immunological compartment

1985 • 113 citations

A viral vaccine vector that expresses foreign genes in lymph nodes and protects against mucosal challenge

1996 • 110 citations

Oral and rectal immunization of adult female volunteers with a recombinant attenuated Salmonella typhi vaccine strain

1996 • 104 citations

Selective Transport of IgA

1991 • 104 citations

Immunological responses to fed protein antigens in mice. II. Oral tolerance for CMI is due to activation of cyclophosphamide-sensitive cells by gut-processed antigen.

1983 • 102 citations

Appearance of secretory IgM and IgA antibodies to Escherichia coli in saliva during early infancy and childhood

1984 • 101 citations

Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells.

1990 • 99 citations

The number and distribution of lymphoid follicles in the human large intestine.

1986 • 99 citations

Human circulating specific antibody‐forming cells after systemic and mucosal immunizations: differential homing commitments and cell surface differentiation markers

1995 • 96 citations

Evidence for CD8+ T-cell immunity to murine rotavirus in the absence of perforin, fas, and gamma interferon

1997 • 95 citations

The Frequency of Cells Secreting Interferon-γ and Interleukin-4, -5, and -10 in the Blood and Duodenal Mucosa of Children with Cow's Milk Hypersensitivity

1997 • 92 citations

Secretory Immunity in the Female Reproductive Tract

1994 • 90 citations

Natural killer activity of gut mucosal lymphoid cells in mice

1981 • 88 citations

Adoptive transfer of gut intraepithelial lymphocytes protects against murine infection with Toxoplasma gondii.

1997 • 85 citations

Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice

1990 • 85 citations

Live oral avirulent Salmonella vaccines

1993 • 83 citations

Immunogenicity of Recombinant Adenovirus-Human Immunodeficiency Virus Vaccines in Chimpanzees Following Intranasal Administration

1994 • 81 citations

Comparison of Intranasal and Intramuscular Immunization against Human Immunodeficiency Virus Type 1 with a DNA-Monophosphoryl Lipid A Adjuvant Vaccine

1998 • 80 citations

Comparative effectiveness of the cholera toxin B subunit and alkaline phosphatase as carriers for oral vaccines

1993 • 79 citations

Repetitive Adenovirus Administration to the Parotid Gland: Role of Immunological Barriers and Induction of Oral Tolerance

1998 • 78 citations

Local Intravaginal Vaccination of the Female Genital Tract

1996 • 77 citations

Intranasal immunization induces long-term protection in mice against a Chlamydia trachomatis genital challenge

1996 • 76 citations

Specific-Antibody-Secreting Cells in the Rectums and Genital Tracts of Nonhuman Primates following Vaccination

1998 • 74 citations

Class I-restricted CTL induction by mucosal immunization with naked DNA encoding measles virus haemagglutinin.

1997 • 72 citations

Developmental relationship between cytotoxic α/β T cell receptor‐positive intraepithelial lymphocytes and Peyer's patch lymphocytes

1993 • 72 citations

Immunogenicity of Recombinant Adenovirus-Respiratory Syncytial Virus Vaccines with Adenovirus Types 4, 5, and 7 Vectors in Dogs and a Chimpanzee

1992 • 69 citations

Borrelia burgdorferi-pulsed dendritic cells induce a protective immune response against tick-transmitted spirochetes

1997 • 69 citations

Respiratory syncytial virus infection in C57BL/6 mice: clearance of virus from the lungs with virus-specific cytotoxic T cells

1991 • 69 citations

Current options for vaccine delivery systems by mucosal routes

1997 • 68 citations

Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection

1991 • 67 citations

Specific immune response in humans following rectal delivery of live typhoid vaccine

1990 • 64 citations

Induction of mucosal immune responses against a heterologous antigen fused to filamentous hemagglutinin after intranasal immunization with recombinant Bordetella pertussis.

1996 • 64 citations

Dendritic Cells and Langerhans Cells in the Uptake of Mucosal Antigens

1999 • 63 citations

The Relative Role of Lymphocyte Granule Exocytosis versus Death Receptor-Mediated Cytotoxicity in Viral Pathophysiology

1998 • 62 citations

Treatment of experimental autoimmune arthritis by nasal administration of a type II collagen-cholera toxoid conjugate vaccine

1999 • 61 citations

Cytotoxic T cells in small intestine epithelial, lamina propria and lung lymphocytes.

1981 • 60 citations

T- and B-cell functions and epitope expression in nonhuman primates immunized with simian immunodeficiency virus antigen by the rectal route.

1993 • 60 citations

Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras

1992 • 59 citations

Acquisition of lymphokine-producing phenotype by CD4+ T cells

1994 • 59 citations

Initial safety and immunogenicity studies of an oral recombinant adenohepatitis B vaccine

1992 • 59 citations

The distribution of immunocompetent cells in the genital tract of HIV-positive women

1996 • 58 citations

Vaccination against pox diseases under immunosuppressive conditions.

1978 • 58 citations

Local and systemic antibody responses to dextran-cholera toxin B subunit conjugates

1995 • 57 citations

Lymphoid and non-lymphoid cells in nasal-associated lymphoid tissue (NALT) in the rat

1990 • 57 citations

Interleukin‐5 expressed by a recombinant virus vector enhances specific mucosal IgA responses in vivo

1993 • 57 citations

The development and structure of mouse nasal-associated lymphoid tissue: an immuno- and enzyme-histochemical study.

1993 • 55 citations

Cholera toxin acts as a potent adjuvant for the induction of cytotoxic T-lymphocyte responses with non-replicating antigens.

1994 • 54 citations

Immunohistochemical characterization of intraepithelial and subepithelial mononuclear cells of the upper airways.

1993 • 54 citations

Organization of Mucosal Lymphoid Tissue

1999 • 53 citations

Immunization with baculovirus-expressed recombinant rotavirus proteins VP1, VP4, VP6, and VP7 induces CD8+ T lymphocytes that mediate clearance of chronic rotavirus infection in SCID mice

1991 • 52 citations

Respiratory syncytial virus infection in cyclophosphamide-treated cotton rats

1982 • 52 citations

Compartmentalization within the Common Mucosal Immune System

1995 • 52 citations

Intranasal Administration of aSchistosoma mansoniGlutathioneS-Transferase-Cholera Toxoid Conjugate Vaccine Evokes Antiparasitic and Antipathological Immunity in Mice

1999 • 51 citations

The development of oral vaccines based on live attenuatedSalmonellastrains

1993 • 51 citations

Reovirus-induced liver disease in severe combined immunodeficient (SCID) mice. A model for the study of viral infection, pathogenesis, and clearance.

1990 • 51 citations

Recombinant cholera toxin B subunit and gene fusion proteins for oral vaccination

1990 • 50 citations

Antibody in Tears, Saliva and Nasal Secretions Following Oral Immunization of Humans with Inactivated Influenza Virus Vaccine

1986 • 50 citations

Targeting and controlled release of antigens for the effective induction of secretory antibody responses

1991 • 50 citations

Colonization in the rectum and uterine cervix with group B streptococci may induce specific antibody responses in cervical secretions of pregnant women

1996 • 49 citations

Inhibition of specific immune responses by feeding protein antigens. II. Effects of prior passive and active immunization.

1979 • 48 citations

Selective tolerization of Th1-like cells after nasal administration of a cholera toxoid-LACK conjugate

1998 • 47 citations

Toward a poliovirus-based simian immunodeficiency virus vaccine: correlation between genetic stability and immunogenicity

1997 • 47 citations

B lymphocytes in human disease

1989 • 47 citations

Expression and gene transcript of Fc receptors for IgG, HLA class II antigens and Langerhans cells in human cervico-vaginal epithelium

1992 • 47 citations

Oral delivery of micro-encapsulated DNA vaccines.

1998 • 46 citations

Functional Characteristics of Lymphocytes Isolated From the Rat Large Intestine

1984 • 44 citations

Detection of Human Cytokine-Secreting Cells in Distinct Anatomical Compartments

1991 • 44 citations

Mucosal immunity in the female genital tract: relevance to vaccination efforts against the human immunodeficiency virus.

1994 • 43 citations

Antigen Delivery Systems: New Approaches to Mucosal Immunization

1994 • 43 citations

Enteric immunization of mice against influenza with recombinant vaccinia.

1994 • 43 citations

Mucosal Transmission of Simian Immunodeficiency Virus

1994 • 42 citations

Direct Gene Transfer to the Respiratory Tract of Mice with Pure Plasmid and Lipid-Formulated DNA

1998 • 39 citations

Host Responses to Respiratory Virus Infection and Immunization

1999 • 39 citations

Salmonellae as oral vaccine carriers.

1995 • 38 citations

Safety and immunogenicity of intramuscular and intravaginal delivery of HIV‐1 DNA constructs to infant chimpanzees

1997 • 38 citations

Mucosal Immunogenicity of a Holotoxin-Like Molecule Containing the Serine-RichEntamoeba histolyticaProtein (SREHP) Fused to the A₂Domain of Cholera Toxin

1998 • 38 citations

Cholera Toxin B Subunit as Transmucosal Carrier‐Delivery and Immunomodulating System for Induction of Antiinfectious and Antipathological Immunitya

1996 • 38 citations

Clinical and immunological response to oral and subcutaneous immunotherapy with grass pollen extracts

1982 • 37 citations

CD8 lymphocyte subpopulations in Peyer's patches induced by reovirus serotype 1 infection.

1990 • 35 citations

The response of gut-associated T lymphocytes to intestinal viral immunization.

1984 • 34 citations

Suppression of delayed-type hypersensitivity and IgE antibody responses to ovalbumin by intranasal administration of Escherichia coli heat-labile enterotoxin B subunit-conjugated ovalbumin

1997 • 32 citations

Inhibition of Specific Immune Responses by Feeding Protein Antigens

1979 • 31 citations

Mucosal vaccination with recombinant poxvirus vaccines protects ferrets against symptomatic CDV infection

1999 • 31 citations

The early appearance of specific cytotoxic T cells in murine gut mucosa.

1980 • 30 citations

The Role of Host Responses in the Recovery of Mice from Sendai Virus Infection

1980 • 30 citations

Vaccination in the 21st Century

1993 • 29 citations

Irradiated mice lose the capacity to 'process' fed antigen for systemic tolerance of delayed-type hypersensitivity.

1987 • 29 citations

Intra-Epithelial Lymphocytes and Non-Lymphoid Cells in the Human Nasal Mucosa

1989 • 29 citations

Oral Immunization with Influenza Virus: Experimental and Clinical Studies

1989 • 27 citations

Applications of molecular microbiology to vaccinology

1997 • 27 citations

The Role of Chemokines in Oral Tolerance.

1996 • 26 citations

Recombinant Viruses as Vectors for Mucosal Immunity

1999 • 26 citations

Tissue distribution of mucosal antibody-producing cells specific for respiratory syncytial virus in severe combined immune deficiency (SCID) mice engrafted with human tonsils

1991 • 24 citations

Conditions affecting enhanced corneal allograft survival by oral immunization.

1998 • 24 citations

Oral hyposensitization of children with pollinosis or house-dust asthma.

1977 • 23 citations

Antigen Trafficking in the Intestinea

1996 • 23 citations

Cytotoxic T cell activity against the 22-kda protein of human respiratory syncytial virus (RSV) is associated with a significant reduction in pulmonary RSV replication

1991 • 23 citations

Lipid matrix-based subunit vaccines: a structure-function approach to oral and parenteral immunization.

1994 • 21 citations

Induction of mucosal immunity in cotton rats to haemagglutinin-esterase glycoprotein of bovine coronavirus by recombinant adenovirus.

1995 • 20 citations

Comparison of the efficacy of replication-defective adenovirus and Nyvac poxvirus as vaccine vectors in mice

1996 • 19 citations

Characterization of the Expression and Immunogenicity of Poliovirus Replicons that Encode Simian Immunodeficiency Virus SIVmac239 Gag or Envelope SU Proteins

1997 • 19 citations

Intranasal administration of diphtheria toxoid. Selecting antibody isotypes using formulations having various lipophilic characteristics

1995 • 18 citations

Arthritis: Animal Models of Oral Tolerancea

1996 • 16 citations

New Generation Vaccines

1993 • 15 citations

Recombinant vaccine delivery systems and encoded vaccines

1994 • 15 citations

Poly(lactide-co-glycolide) Microencapsulation of Vaccines for Mucosal Immunization

1996 • 11 citations

Attenuated Salmonella as Vectors for Oral Immunization

1996 • 11 citations

A plaque hybridization assay for quantifying and cloning infectious human immunodeficiency virus type 1 virions

1998 • 11 citations

Mucosal Immunity and the Gut Epithelium: Interactions in Health and Disease

1996 • 10 citations