Mechanisms for Mucosal Immunogenicity and Adjuvancy of Escherichia coli Labile Enterotoxin

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin

1992 • 810 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

1991 • 530 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells.

1989 • 444 citations

Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.

1995 • 392 citations

Towards a comprehensive view of immunoglobulin class switching

1993 • 373 citations

Isolation and characterization of homogeneous heat-labile enterotoxins with high specific activity from Escherichia coli cultures

1979 • 345 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 343 citations

Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin

1980 • 328 citations

Cholera toxin and cholera B subunit as oral—mucosal adjuvant and antigen vector systems

1993 • 324 citations

IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

1988 • 308 citations

Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens

1988 • 283 citations

Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.

1987 • 259 citations

Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells.

1988 • 242 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.

1990 • 226 citations

Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant

1993 • 208 citations

Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin.

1994 • 192 citations

Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens

1992 • 177 citations

Salmonella typhimuriumaroA mutants as carriers of the Escherichia coli heat-labile enterotoxin B subunit to the murine secretory and systemic immune systems

1987 • 127 citations

Interleukin 4/B cell stimulatory factor 1: one lymphokine, many functions ¹

1987 • 124 citations

Cholera toxin adjuvant greatly promotes antigen priming of T cells

1993 • 121 citations

Comparison of receptors for cholera and Escherichia coli enterotoxins in human intestine

1985 • 108 citations

A rapid method to determine the isotype and specificity of coproantibodies in mice infected with Trichinella or fed cholera toxin

1991 • 75 citations

Local and Systemic Antibody Responses to Naturally Acquired Enterotoxigenic Escherichia coli Diarrhea in an Endemic Area

1986 • 69 citations

Function of αβ TCR⁺ intestinal intraepithelial lymphocytes: T_h1-and T_h2-type cytokine production by CD4⁺ CD8⁻ and CD4⁺ CD8⁺ T cells for helper activity

1993 • 68 citations

Killed Campylobacter elicits immune response and protection when administered with an oral adjuvant

1993 • 60 citations

Ir gene control of the murine secretory IgA response to cholera toxin

1987 • 43 citations

Adjuvant effect of cholera toxin on the mucosal immune response to soluble proteins. Differences between mouse strains and protein antigens.

1989 • 40 citations

Antigen-specific IGG2A production in response to prostaglandin E2, immune complexes, and IFN-gamma.

1991 • 23 citations

Cloning and molecular characterization of the B subunit of Escherichia coli heat-labile enterotoxin

1983 • 21 citations