Dendritic cells and tolerance induction

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1973 • 2,286 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Cell migration, chimerism, and graft acceptance

1992 • 1,075 citations

Epidermal Langerhans cells are derived from cells originating in bone marrow

1979 • 879 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Negative selection of lymphocytes

1994 • 810 citations

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

1982 • 807 citations

Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance

1993 • 795 citations

Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice.

1978 • 791 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.

1990 • 561 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

The regulation of immune responses to dietary protein antigens

1987 • 489 citations

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

1995 • 472 citations

Identification of proliferating dendritic cell precursors in mouse blood.

1992 • 445 citations

An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.

1993 • 427 citations

The distinct surface of human blood dendritic cells, as observed after an improved isolation method.

1990 • 402 citations

Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium.

1993 • 395 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Cultured Human Langerhans Cells Resemble Lymphoid Dendritic Cells in Phenotype and Function

1989 • 376 citations

Nitric oxide induces apoptosis in mouse thymocytes.

1995 • 356 citations

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

1989 • 318 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo.

1993 • 284 citations

BONE MARROW-DERIVED DENDRITIC CELL PROGENITORS (NLDC 145+, MHC CLASS II+, B7-1dim, B7-2−) INDUCE ALLOANTIGEN-SPECIFIC HYPORESPONSIVENESS IN MURINE T LYMPHOCYTES1,2

1995 • 281 citations

Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4+ T helper 1 cells.

1991 • 251 citations

Molecules involved in T-cell costimulation

1993 • 237 citations

Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone.

1988 • 226 citations

Endotoxin-mediated dendritic cell release from the intestine. Characterization of released dendritic cells and TNF dependence.

1995 • 226 citations

Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer.

1992 • 224 citations

Migration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues.

1988 • 215 citations

Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis.

1996 • 210 citations

Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival.

1995 • 202 citations

Bone marrow origin of Ia-positive cells in the medulla rat thymus.

1981 • 197 citations

Programmed Cell Death of T Cells Signaled by the T Cell Receptor and the α₃Domain of Class I MH

1991 • 196 citations

Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract.

1994 • 190 citations

Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor.

1995 • 185 citations

Studies of the cell surface of mouse dendritic cells and other leukocytes

1981 • 182 citations

Microchimerism, dendritic cell progenitors and transplantation tolerance

1995 • 181 citations

COMBINED TRANSPLANTATION OF LIVER AND KIDNEY FROM THE SAME DONOR PROTECTS THE KIDNEY FROM REJECTION AND IMPROVES KIDNEY GRAFT SURVIVAL

1995 • 180 citations

Isolation and characterization of dendritic cells from mouse heart and kidney.

1994 • 179 citations

Control of the Immune Response at the Level of Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes

1989 • 163 citations

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

1984 • 158 citations

The injured cell: the role of the dendritic cell system as a sentinel receptor pathway

1995 • 154 citations

Immunoregulatory mechanisms of the eye

1992 • 153 citations

Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity.

1995 • 152 citations

Induction of immune responses in vivo with small numbers of veiled (dendritic) cells.

1983 • 149 citations

MIGRATION PATTERNS OF DENDRITIC LEUKOCYTES

1990 • 139 citations

Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: An in vivo approach to investigate la gene function

1987 • 134 citations

FURTHER STUDIES OF VETO ACTIVITY IN RHESUS MONKEY BONE MARROW IN RELATION TO ALLOGRAFT TOLERANCE AND CHIMERISM

1994 • 130 citations

STUDIES OF THE ROLE OF THE THYMIC ENVIRONMENT IN THE INDUCTION OF TOLERANCE TO MHC ANTIGENS

1985 • 127 citations

Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo.

1995 • 121 citations

Defective regional immunity in the respiratory tract of neonates is attributable to hyporesponsiveness of local dendritic cells to activation signals.

1995 • 114 citations

Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy.

1990 • 112 citations

Quantitation of Surface Antigens on Cultured Murine Epidermal Langerhans Cells: Rapid and Selective Increase in the Level of Surface MHC Products

1988 • 103 citations

Distinctive humoral immune responses following anterior chamber and intravenous administration of soluble antigen. Evidence for active suppression of IgG2-secreting B lymphocytes.

1990 • 97 citations

Freshly isolated spleen dendritic cells and epidermal Langerhans cells undergo similar phenotypic and functional changes during short-term culture.

1990 • 90 citations

ROLE OF THE THYMUS IN TOLERANCE

1966 • 90 citations

Influence of dendritic cells on tumor growth.

1985 • 84 citations

Maturational steps of bone marrow-derived dendritic murine epidermal cells. Phenotypic and functional studies on Langerhans cells and Thy-1+ dendritic epidermal cells in the perinatal period.

1989 • 83 citations

Understanding the dendritic cell lineage through a study of cytokine receptors.

1994 • 81 citations

Transplantation milestones. Viewed with one- and two-way paradigms of tolerance

1995 • 74 citations

Ontogeny of Ia-Positive and Thy-1-Positive Leukocytes of Murine Epidermis

1986 • 68 citations

Migration patterns of dendritic leukocytes

1989 • 66 citations

Liver transplants contribute to their own success

1996 • 61 citations

CD8 functions as an inhibitory ligand in mediating the immunoregulatory activity of CD8+ cells.

1990 • 55 citations

Functional studies of major histocompatibility class II-positive dendritic cells and resident tissue macrophages isolated from the rat iris.

1995 • 41 citations

The Role of Antigen-Presenting Cells in the Regulation of Delayed-Type Hypersensitivity

1993 • 40 citations

Different migration patterns of antigen-presenting cells correlate with Th1/Th2-type responses in mice.

1995 • 36 citations

Immunological tolerance to a defined myelin basic protein antigen administered intrathymically.

1994 • 29 citations

Implantation of cultured thymic fragments in congenitally athymic nude rats: ignorance of thymic epithelial haplotype in generation of alloreactivity.

1986 • 25 citations

Origin and steady-state turnover of major histocompatibility complex Class II-positive dendritic cells and resident-tissue macrophages in the iris of the rat eye

1996 • 25 citations

The role of antigen-presenting cells in the regulation of delayed-type hypersensitivity. I. Spleen dendritic cells.

1992 • 24 citations

The dendritic cell system and anti-tumour immunity.

1993 • 22 citations

Role of the thymus in tolerance. IX. Inhibition of experimental autoallergic encephalomyelitis by intrathymic injection of encephalitogen.

1970 • 18 citations

The Changing Immunology of Organ Transplantation

1995 • 11 citations

Ex-Vivo treatment of antigen presenting cells with CTLA4Ig and peptide prevents EAE in the lewis rat

1996 • 4 citations