Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina

Immunochemical quantitation of antigens by single radial immunodiffusion

1965 • 9,369 citations

The common mucosal immune system and current strategies for induction of immune responses in external secretions

1987 • 810 citations

Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues.

1979 • 732 citations

Handbook of Mucosal Immunology

1994 • 711 citations

Actions of cholera toxin and the prevention and treatment of cholera

1981 • 532 citations

Identification ofEscherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM1-ELISA) procedure

1978 • 359 citations

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

1989 • 252 citations

Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces

1994 • 250 citations

Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit

1993 • 241 citations

Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memory.

1991 • 226 citations

Oral vaccination. Identification of classes of proteins that provoke an immune response upon oral feeding.

1988 • 211 citations

Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant

1996 • 211 citations

Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin.

1994 • 192 citations

Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the Cholera toxin B subunit

1996 • 191 citations

Human immune responses to influenza virus vaccines administered by systemic or mucosal routes

1995 • 180 citations

A recombinant Salmonella typhimurium vaccine induces local immunity by four different routes of immunization

1995 • 179 citations

Saliva, breast milk, and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease

1986 • 171 citations

Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.

1989 • 161 citations

Specific secretory immune responses in the female genital tract following intranasal immunization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus

1995 • 153 citations

Induction of compartmentalized B-cell responses in human tonsils

1995 • 149 citations

Induction of Mucosal and Systemic Immunity to a Recombinant Simian Immunodeficiency Viral Protein

1992 • 142 citations

Mucosal Immunity and Protection after Intranasal Immunization with Recombinant Adenovirus Expressing Herpes Simplex Virus Glycoprotein B

1993 • 136 citations

Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination

1990 • 124 citations

Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant.

1994 • 107 citations

A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins

1995 • 100 citations

Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy

1996 • 99 citations

Immunoglobulin G antibodies in human vaginal secretions after parenteral vaccination

1994 • 95 citations

Antibody responses in volunteers induced by nasal influenza vaccine combined with Escherichia coli heat-labile enterotoxin B subunit containing a trace amount of the holotoxin

1996 • 93 citations

Resistance of adults to challenge with influenza A wild-type virus after receiving live or inactivated virus vaccine

1986 • 89 citations

Local Intravaginal Vaccination of the Female Genital Tract

1996 • 77 citations

Comparison of IgA versus IgG monoclonal antibodies for passive immunization of the murine respiratory tract

1992 • 70 citations

Mucosal Immunity in the Female and Male Reproductive Tracts

1994 • 69 citations

Induction of Mucosal Antibodies by Live Attenuated and Inactivated Influenza Virus Vaccines in the Chronically III Elderly

1996 • 63 citations

Local and systemic antibody responses to dextran-cholera toxin B subunit conjugates

1995 • 57 citations

Induction of antibody response to Chlamydia trachomatis in the genital tract by oral immunization

1991 • 56 citations

Evaluation of different immunization schedules for oral cholera B subunit-whole cell vaccine in Swedish volunteers

1993 • 52 citations

BACTERIAL ENTERIC INFECTIONS AND VACCINE DEVELOPMENT

1992 • 52 citations

Colonization in the rectum and uterine cervix with group B streptococci may induce specific antibody responses in cervical secretions of pregnant women

1996 • 49 citations

Immune response of the female rat genital tract after oral and local immunization with keyhole limpet hemocyanin conjugated to the cholera toxin B subunit

1993 • 43 citations

Effects of cholera toxin adjuvant on IgE antibody response to orally or nasally administered ovalbumin

1994 • 39 citations

Insertion of a HIV-1-neutralizing epitope in a surface-exposed internal region of the cholera toxin B-subunit

1994 • 37 citations

Cells Producing Immunoglobulins and other Immune Factors in Human Nasal Mucosa

1985 • 27 citations