Myosin light-chain 1/3 gene alternative splicing: cis regulation is based upon a hierarchical compatibility between splice sites.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression

1987 • 2,333 citations

Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

1977 • 2,070 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

SPLICING OF MESSENGER RNA PRECURSORS

1986 • 1,233 citations

Splicing of Messenger RNA Precursors

1987 • 919 citations

STUDIES ON THE PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSES

1953 • 821 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

ALTERNATIVE SPLICING: A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES

1987 • 712 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

PRE-mRNA SPLICING

1986 • 673 citations

Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA

1979 • 623 citations

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

1987 • 594 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis

1978 • 491 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

The "Spliceosome": Yeast Pre-Messenger RNA Associates with a 40 S Complex in a Splicing-Dependent Reaction

1985 • 421 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

1989 • 391 citations

An RNA Processing Activity That Debranches RNA Lariats

1985 • 300 citations

Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?

1988 • 280 citations

Alternative splicing caused by RNA secondary structure

1985 • 274 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns

1989 • 267 citations

Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing.

1984 • 265 citations

Signals for the selection of a splice site in pre-mRNA

1987 • 247 citations

Mutually exclusive splicing of α-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing

1989 • 238 citations

The role of the mammalian branchpoint sequence in pre-mRNA splicing.

1988 • 215 citations

5′ cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5′ splice region, not by the conserved 5′ GU

1987 • 206 citations

UACUAAC is the preferred branch site for mammalian mRNA splicing.

1989 • 180 citations

A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation.

1987 • 179 citations

Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms.

1987 • 174 citations

The Rat α-Tropomyosin Gene Generates a Minimum of Six Different mRNAs Coding for Striated, Smooth, and Nonmuscle Isoforms by Alternative Splicing

1988 • 167 citations

Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing.

1988 • 163 citations

Generation of Protein Isoform Diversity by Alternative Splicing: Mechanistic and Biological Implications

1987 • 163 citations

A binding consensus: RNA-protein interactions in splicing, snRNPs, and sex

1989 • 162 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA

1986 • 148 citations

A role for exon sequences in alternative splicing of the human fibronection gene

1987 • 145 citations

Amount of RNA secondary structure required to induce an alternative splice.

1987 • 128 citations

The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing.

1988 • 105 citations

Alternative processing of bovine growth hormone mRNA is influenced by downstream exon sequences.

1989 • 97 citations

Branch point selection in alternative splicing of tropomyosin pre-mRNAs

1989 • 89 citations

Myosin light-chain 1 and 3 gene has two structurally distinct and differentially regulated promoters evolving at different rates.

1985 • 85 citations

The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA.

1987 • 84 citations

U1 small nuclear ribonucleoproteins are required early during spliceosome assembly.

1987 • 80 citations

Use of recombinant DNA technology to program eukaryotic cells to synthesize rat proinsulin: a rapid expression assay for cloned genes.

1982 • 69 citations

Alternative Splicing In The Control Of Gene Expression

1989 • 66 citations

Amount of RNA Secondary Structure Required to Induce an Alternative Splice

1987 • 59 citations

Inhibition of splicing but not cleavage at the 5' splice site by truncating human beta-globin pre-mRNA.

1986 • 58 citations

Alternative Splicing: A Ubiquitous Mechanism For The Generation Of Multiple Protein Isoforms From Single Genes

1987 • 40 citations

Short donor site sequences inserted within the intron of beta-globin pre-mRNA serve for splicing in vitro.

1988 • 36 citations

Role of the branch site/3'-splice site region in adenovirus-2 E1A pre-mRNA alternative splicing: evidence for 5'- and 3'-splice site co-operation

1989 • 34 citations

A subfragment of the β tropomyosin gene is alternatively spliced when transfected into differentiating muscle cells

1989 • 33 citations

A Combination of RNase H and S1 nuclease Circumvents an artefact inherent to conventional S1 analysis of RNA splicing

1987 • 27 citations

Correct in vivo splicing of the mouse immunoglobulin kappa light-chain pre-mRNA is dependent on 5' splice-site position even in the absence of transcription.

1988 • 23 citations

Accurate 5' splice-site selection in mouse kappa immunoglobulin light chain premessenger RNAs is not cell-type-specific.

1987 • 22 citations

Comparison of in vitro and in vivo splice site selection in kappa-immunoglobulin precursor mRNA.

1988 • 17 citations

In vitro splicing of kappa immunoglobulin precursor mRNA.

1987 • 13 citations

Developmentally Regulated Expression of a Truncated Myosin Light-Chain 1_F/3_F Gene

1987 • 11 citations

In Vitro Splicing of Kappa Immunoglobulin Precursor mRNA

1987 • 10 citations

Comparison of in Vitro and in Vivo Splice Site Selection in κ-Immunoglobulin Precursor mRNA

1988 • 6 citations

Deleted Work

1955 • 0 citations