The Regulatory Role of Vα14 NKT Cells in Innate and Acquired Immune Response

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Interleukin-18 Regulates Both Th1 and Th2 Responses

2001 • 1,284 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

1992 • 1,041 citations

CD1 Recognition by Mouse NK1 ⁺ T Lymphocytes

1995 • 903 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

NKT cells: facts, functions and fallacies

2000 • 875 citations

A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells

2001 • 864 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells

1999 • 856 citations

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

1998 • 837 citations

Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells

2000 • 812 citations

NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

2000 • 690 citations

Biology of Trypanosoma Cruzi

1973 • 679 citations

Human T-cell receptor variable gene segment families

1995 • 663 citations

CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution

1998 • 649 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 645 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells

1999 • 624 citations

CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4

1997 • 612 citations

Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

2001 • 605 citations

Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo

2000 • 589 citations

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

2001 • 556 citations

Multiple immuno-regulatory defects in type-1 diabetes

2002 • 548 citations

Critical contribution of liver natural killer T cells to a murine model of hepatitis

2000 • 532 citations

Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.

1995 • 517 citations

A Thymic Precursor to the NK T Cell Lineage

2002 • 517 citations

Role of NK1.1 ⁺ T Cells in a T _H 2 Response and in Immunoglobulin E Production

1995 • 508 citations

Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells

1997 • 501 citations

Impaired NK1+ T Cell Development and Early IL-4 Production in CD1-Deficient Mice

1997 • 494 citations

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells

1998 • 474 citations

α/β–T Cell Receptor (TCR)+CD4−CD8− (NKT) Thymocytes Prevent Insulin-dependent Diabetes Mellitus in Nonobese Diabetic (NOD)/Lt Mice by the Influence of Interleukin (IL)-4 and/or IL-10

1998 • 473 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

CD1d-restricted Recognition of Synthetic Glycolipid Antigens by Human Natural Killer T Cells

1998 • 445 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

NKT cells derive from double-positive thymocytes that are positively selected by CD1d

2001 • 421 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family

1987 • 397 citations

Augmentation of Vα14 Nkt Cell–Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a–Induced Hepatitis

2000 • 395 citations

Overexpression of Natural Killer T Cells Protects Vα14-Jα281 Transgenic Nonobese Diabetic Mice against Diabetes

1998 • 390 citations

Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis

2001 • 390 citations

Sequential production of interferon-γ by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide

2002 • 382 citations

A Natural Killer T (NKT) Cell Developmental Pathway Involving a Thymus-dependent NK1.1−CD4+ CD1d-dependent Precursor Stage

2002 • 374 citations

Adaptive Immune Response of Vγ2Vδ2 ⁺ T Cells During Mycobacterial Infections

2002 • 368 citations

Susceptibility of Mice Deficient in CD1D or TAP1 to Infection with Mycobacterium tuberculosis

1999 • 361 citations

Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells

1997 • 360 citations

Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site

1999 • 360 citations

T cells in inflammatory bowel disease: protective and pathogenic roles

1995 • 359 citations

Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype.

1999 • 359 citations

Early quantitative and functional deficiency of NK1⁺‐like thymocytes in the NOD mouse

1996 • 359 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells

1999 • 332 citations

Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells

2000 • 330 citations

Natural Killer T Cell Ligand α-Galactosylceramide Enhances Protective Immunity Induced by Malaria Vaccines

2002 • 314 citations

Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis.

1995 • 310 citations

Immunization with α-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis

1999 • 306 citations

Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice.

1994 • 304 citations

Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

2001 • 299 citations

Cutting Edge: Activation of NK T Cells by CD1d and α-Galactosylceramide Directs Conventional T Cells to the Acquisition of a Th2 Phenotype

1999 • 296 citations

The role of natural killer cells in immune surveillance of cancer

1995 • 290 citations

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice.

1996 • 290 citations

Cd1-Restricted Nk T Cells Protect Nonobese Diabetic Mice from Developing Diabetes

2001 • 273 citations

Requirement for natural killer T (NKT) cells in the induction of allograft tolerance

2001 • 270 citations

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.

1996 • 268 citations

Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice

2000 • 265 citations

NK1.1⁺ CD4⁺ CD8‐ thymocytes with specific lymphokine secretion

1993 • 265 citations

Cutting edge: inhibition of experimental tumor metastasis by dendritic cells pulsed with alpha-galactosylceramide.

1999 • 264 citations

α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria

2000 • 261 citations

Antitumor cytotoxicity mediated by ligand-activated human V alpha24 NKT cells.

1999 • 260 citations

NKT cells are phenotypically and functionally diverse

1999 • 259 citations

Association Between αβTCR+CD4−CD8− T-Cell Deficiency and IDDM in NOD/Lt Mice

1997 • 258 citations

Relative Sensitivity of Hepatitis B Virus and Other Hepatotropic Viruses to the Antiviral Effects of Cytokines

2000 • 257 citations

Differential Expression of NK T Cell Vα24JαQ Invariant TCR Chain in the Lesions of Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy

2000 • 256 citations

NK Markers Are Expressed on a High Percentage of Virus-Specific CD8+ and CD4+ T Cells

2000 • 250 citations

NK T Cell-Derived IL-10 Is Essential for the Differentiation of Antigen-Specific T Regulatory Cells in Systemic Tolerance

2001 • 244 citations

Predominant expression of invariant V_α14⁺ TCR α chain in NK1.1⁺ T cell populations

1995 • 243 citations

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction.

1994 • 235 citations

Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production

2001 • 232 citations

Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

1987 • 230 citations

Cutting Edge: Inhibition of Experimental Tumor Metastasis by Dendritic Cells Pulsed with α-Galactosylceramide

1999 • 230 citations

IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects.

1998 • 229 citations

Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice.

1997 • 228 citations

Mechanisms of the Antimetastatic Effect in the Liver and of the Hepatocyte Injury Induced by α-Galactosylceramide in Mice

2001 • 217 citations

A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system.

1999 • 209 citations

Positive darwinian selection observed at the variable-region genes of immunoglobulins.

1989 • 206 citations

Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4-CD8- and alpha beta TCR+NK1.1+ cells.

1990 • 196 citations

Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

1999 • 196 citations

Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation.

1995 • 194 citations

IFN-γ-Inducing Factor/IL-18 Administration Mediates IFN-γ- and IL-12-Independent Antitumor Effects

1998 • 185 citations

MIP-2 Recruits NKT Cells to the Spleen During Tolerance Induction

2001 • 177 citations

Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse

2001 • 176 citations

Liver NK1.1+ CD4+ alpha beta T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis.

1996 • 175 citations

Dysfunction of T cell receptor AV24AJ18+,BV11+ double-negative regulatory natural killer T cells in autoimmune diseases

2001 • 173 citations

Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice

2000 • 169 citations

Involvement of decidual Vα14 NKT cells in abortion

2000 • 169 citations

A Novel Function of Vα14+CD4+NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System

1999 • 163 citations

Monocyte Chemoattractant Protein-1-Dependent Increase of Vα14 NKT Cells in Lungs and Their Roles in Th1 Response and Host Defense in Cryptococcal Infection

2001 • 158 citations

Inhibition of T Helper Cell Type 2 Cell Differentiation and Immunoglobulin E Response by Ligand-Activated Vα14 Natural Killer T Cells

1999 • 158 citations

Binding and Antigen Presentation of Ceramide-Containing Glycolipids by Soluble Mouse and Human Cd1d Molecules

1999 • 154 citations

A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection.

1996 • 154 citations

Activation of Vα14⁺Natural Killer T Cells by α-Galactosylceramide Results in Development of Th1 Response and Local Host Resistance in Mice Infected withCryptococcus neoformans

2001 • 150 citations

Characterization of the cell surface receptor for granulocyte-macrophage colony-stimulating factor.

1986 • 149 citations

CD4+ Vα14 natural killer T cells are essential for acceptance of rat islet xenografts in mice

2000 • 147 citations

Cutting Edge: A Major Fraction of Human Bone Marrow Lymphocytes Are Th2-Like CD1d-Reactive T Cells That Can Suppress Mixed Lymphocyte Responses

2001 • 147 citations

NK1.1+ thymocytes. Adult murine CD4-, CD8- thymocytes contain an NK1.1+, CD3+, CD5hi, CD44hi, TCR-V beta 8+ subset.

1990 • 141 citations

α-Galactosylceramide Induces Early B-Cell Activation through IL-4 Production by NKT Cells

2000 • 141 citations

T Cell Receptors in Murine Autoimmune Diseases

1989 • 137 citations

Extrathymic development of V alpha 14-positive T cells.

1993 • 132 citations

In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development

1998 • 128 citations

Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver.

1991 • 124 citations

IL-18 Enhances IL-4 Production by Ligand-Activated NKT Lymphocytes: A Pro-Th2 Effect of IL-18 Exerted Through NKT Cells

2001 • 124 citations

Costimulation-Dependent Modulation of Experimental Autoimmune Encephalomyelitis by Ligand Stimulation of Vα14 NK T Cells

2001 • 123 citations

Long-Term Survival of Corneal Allografts Is Dependent on Intact CD1d-Reactive NKT Cells

2002 • 123 citations

Induction of Germline Transcription in the TCRγ Locus by Stat5

1999 • 120 citations

Sequence and expression of transcripts of the T-cell antigen receptor alpha-chain gene in a functional, antigen-specific suppressor-T-cell hybridoma.

1986 • 118 citations

Homogenous junctional sequence of the V14+ T-cell antigen receptor alpha chain expanded in unprimed mice.

1990 • 114 citations

NK T Cell-Induced Protection Against Diabetes in Vα14-Jα281 Transgenic Nonobese Diabetic Mice Is Associated with a Th2 Shift Circumscribed Regionally to the Islets and Functionally to Islet Autoantigen

2001 • 113 citations

Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes

2000 • 113 citations

Dominant expression of a distinctive V14+ T-cell antigen receptor alpha chain in mice.

1991 • 101 citations

Essential requirement of an invariant V alpha 14 T cell antigen receptor expression in the development of natural killer T cells.

1996 • 101 citations

Experimental production of possible autoimmune castritis followed by macrocytic anemia in athymic nude mice.

1980 • 92 citations

Structural requirements for antigen presentation by mouse CD1

2000 • 84 citations

Positive selection of invariant V alpha 14+ T cells by non-major histocompatibility complex-encoded class I-like molecules expressed on bone marrow-derived cells.

1995 • 84 citations

DuringTrypanosoma cruziInfection CD1d-Restricted NK T Cells Limit Parasitemia and Augment the Antibody Response to a Glycophosphoinositol-Modified Surface Protein

2002 • 82 citations

Heterogeneity of NK1.1+ T Cells in the Bone Marrow: Divergence from the Thymus

1999 • 78 citations

Corepression of RelA and c-Rel Inhibits Immunoglobulin κ Gene Transcription and Rearrangement in Precursor B Lymphocytes

1996 • 70 citations

CD40‐deficient dendritic cells producing interleukin‐10, but not interleukin‐12, induce T‐cell hyporesponsiveness in vitro and prevent acute allograft rejection

1999 • 69 citations

IL-7 reverses NK1⁺ Tcell-defective IL-4 production in the non-obese diabetic mouse

1996 • 69 citations

A novel recognition motif of human NKT antigen receptor for a glycolipid ligand

1999 • 67 citations

Resistance of Natural Killer T Cell–Deficient Mice to Systemic Shwartzman Reaction

2000 • 63 citations

Predominant use of a particular α-chain in suppressor T cell hybridomas specific for keyhole limpet hemocyanin

1989 • 62 citations

Induction of differentiation of pre-NKT cells to mature Vα14 NKT cells by granulocyte/macrophage colony-stimulating factor

1999 • 56 citations

Decreases in Interleukin-4 Secretion by Invariant CD4−CD8−Vα24JαQ T Cells in Peripheral Blood of Patients with Relapsing–Remitting Multiple Sclerosis

2001 • 55 citations

Development of Valpha4+ NK T cells in the early stages of embryogenesis.

1996 • 52 citations

Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to Vα14 NKT cells

2001 • 51 citations

IL-7 Up-Regulates IL-4 Production by Splenic NK1.1+ and NK1.1− MHC Class I-Like/CD1-Dependent CD4+ T Cells

1999 • 50 citations

Coordinate Transcription and V(D)J Recombination of the Kappa Immunoglobulin Light-Chain Locus: NF-κB-Dependent and -Independent Pathways of Activation

1997 • 42 citations

Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non‐deletional mechanism

1992 • 42 citations

Interleukin-10 inhibits the capacity of synovial macrophages to function as antigen-presenting cells

1998 • 42 citations

Gene expression in NKT cells: defining a functionally distinct CD1d-restricted T cell subset

2001 • 38 citations

Diabetes Prone BB Rats are Severely Deficient in Natural Killer T Cells

1999 • 35 citations

Regulation of experimental autoimmune encephalomyelitis by natural killer(NK) cells

1999 • 21 citations

[Study on molecular evolution for both variable segments of immunoglobulin heavy chain and T cell receptor].

1989 • 2 citations

Deleted Work

1955 • 0 citations