Coordinate Transcription and V(D)J Recombination of the Kappa Immunoglobulin Light-Chain Locus: NF-κB-Dependent and -Independent Pathways of Activation

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

V(D)J Recombination: Molecular Biology and Regulation

1992 • 464 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1989 • 432 citations

Regulation of the Assembly and Expression of Variable-Region Genes

1986 • 402 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

1987 • 346 citations

Recombination between immunoglobulin variable region gene segments is enhanced by transcription

1986 • 308 citations

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.

1996 • 304 citations

ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role ofcis-Acting Elements

1996 • 295 citations

Immunoglobulin Gene Transcription

1991 • 294 citations

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

1991 • 289 citations

Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line.

1991 • 240 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region.

1989 • 213 citations

Transcription of the unrearranged mouse Cκ locus: Sequence of the initiation region and comparison of activity with a rearranged Vκ-Cκ gene

1981 • 190 citations

Deletion of the Igκ Light Chain Intronic Enhancer/Matrix Attachment Region Impairs but Does Not Abolish VκJκ Rearrangement

1996 • 172 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes

1996 • 166 citations

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

1983 • 165 citations

Transforming Growth Factor β and Cyclosporin A Inhibit the Inducible Activity of the Interleukin-2 Gene in T Cells Through a Noncanonical Octamer-Binding Site

1993 • 148 citations

Chromatin changes accompany immunoglobulin κ gene activation: a potential control region within the gene

1982 • 138 citations

Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site.

1993 • 112 citations

Joining of VK to JK gene segments in a retroviral vector introduced into lymphoid cells

1984 • 110 citations

Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene.

1993 • 85 citations

A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.

1993 • 81 citations

Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line

1984 • 77 citations

Induction of κ Transcription by Interferon-γ Without Activation of NF-κB

1988 • 75 citations

Corepression of RelA and c-Rel Inhibits Immunoglobulin κ Gene Transcription and Rearrangement in Precursor B Lymphocytes

1996 • 70 citations

Early genetic events in T cell development analyzed by in situ hybridization.

1987 • 68 citations

Rearrangement-Enhancing Element Upstream of the Mouse Immunoglobulin Kappa Chain J Cluster

1996 • 67 citations

Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independent of methylatlon status

1984 • 65 citations

Improved downward capillary transfer for blotting of DNA and RNA.

1994 • 65 citations

V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.

1990 • 64 citations

The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin Vκ-Jκ joining

1995 • 59 citations

The temporal order of appearance of transcripts from unrearranged and rearranged Ig genes in murine fetal liver.

1990 • 58 citations

Function and Control of Recombination‐Activating Gene Activity^a

1992 • 58 citations

Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice.

1987 • 49 citations

Methylation status of immunoglobulin x e segments correlates with their recombination potential

1993 • 49 citations

Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation.

1991 • 44 citations

B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment.

1987 • 38 citations

Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions

1993 • 38 citations

The intronic immunoglobulin ϰ gene enhancer acts independently on rearrangement and on transcription

1993 • 35 citations

Identification of a second inducible DNA-protein interaction in the kappa immunoglobulin enhancer

1990 • 35 citations

Mechanisms that control antigen receptor variable region gene assembly

1994 • 35 citations

Promotion of V(D)J recombinational accessibility by the intronic Ek element: role of the κB motif

1995 • 31 citations

Immunoglobulin x light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement

1989 • 28 citations

An AP1 binding site upstream of the kappa immunoglobulin intron enhancer binds inducible factors and contributes to expression

1994 • 22 citations

IFN-gamma induces the kappa intron enhancer via an IFN-stimulated response element.

1996 • 10 citations

Studies of V(D)J Recombination with Extrachromosomal Substrates

1988 • 10 citations

Octamer independent activation of transcription from the kappa immunoglobulin germline promoter

1996 • 9 citations