Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity

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2007 • 1,832 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

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Adaptive immunity maintains occult cancer in an equilibrium state

2007 • 1,307 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

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1997 • 1,137 citations

The American Journal of Gastroenterology

2003 • 990 citations

Interleukin 15: biology and relevance to human disease

2001 • 947 citations

IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

2002 • 877 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

1998 • 775 citations

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

2002 • 764 citations

Interleukin-18 Binding Protein

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THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

1999 • 712 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

2003 • 646 citations

IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production

1998 • 636 citations

A proinflammatory role for IL-18 in rheumatoid arthritis

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Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

Expanding the effector CD4 T-cell repertoire: the Th17 lineage

2006 • 595 citations

Coordinated and Distinct Roles for IFN-αβ, IL-12, and IL-15 Regulation of NK Cell Responses to Viral Infection

2002 • 594 citations

SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

2003 • 580 citations

The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

1996 • 492 citations

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2001 • 445 citations

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation.

1995 • 445 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

2001 • 441 citations

IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

1999 • 435 citations

Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γ _c Receptors

2005 • 434 citations

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

2000 • 419 citations

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 417 citations

Converting IL-15 to a superagonist by binding to soluble IL-15Rα

2006 • 388 citations

Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

1997 • 381 citations

15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats

2000 • 381 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

1995 • 363 citations

IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6

2000 • 343 citations

Interleukin-15 protects from lethal apoptosis in vivo

1997 • 339 citations

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

2000 • 335 citations

Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β

2001 • 302 citations

The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation

2006 • 295 citations

Peroxisome Proliferator-Activated Receptor-γ Agonist 15-Deoxy-Δ12,1412,14-Prostaglandin J2 Ameliorates Experimental Autoimmune Encephalomyelitis

2002 • 292 citations

Interleukin‐18 and Host Defense against Infection

2003 • 290 citations

Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development

1998 • 289 citations

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production

2001 • 286 citations

Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells

2001 • 286 citations

Attenuation of Murine Collagen-Induced Arthritis by a Novel, Potent, Selective Small Molecule Inhibitor of IκB Kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), Occurs via Reduction of Proinflammatory Cytokines and Antigen-Induced T Cell Proliferation

2004 • 278 citations

A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts

2003 • 276 citations

Interleukin-2 and interleukin-15: immunotherapy for cancer

2002 • 274 citations

Targeting interleukin‐15 in patients with rheumatoid arthritis: A proof‐of‐concept study

2005 • 262 citations

A fully dissociated compound of plant origin for inflammatory gene repression

2005 • 261 citations

Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus

2005 • 248 citations

A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity

2002 • 237 citations

Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo.

1998 • 234 citations

A highly selective inhibitor of IκB kinase, BMS‐345541, blocks both joint inflammation and destruction in collagen‐induced arthritis in mice

2003 • 213 citations

Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis

2001 • 212 citations

Peroxisome Proliferator-Activated Receptor α Agonists as Therapy for Autoimmune Disease

2004 • 210 citations

Inhibition of Keratinocyte Apoptosis by IL-15: A New Parameter in the Pathogenesis of Psoriasis?

2000 • 209 citations

Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

1997 • 201 citations

Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-α production in mice

2001 • 201 citations

Involvement of Caspase-1 and Caspase-3 in the Production and Processing of Mature Human Interleukin 18 in Monocytic THP.1 Cells

1997 • 198 citations

Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis

2001 • 195 citations

IL-15 Is Highly Expressed in Inflammatory Bowel Disease and Regulates Local T Cell-Dependent Cytokine Production

2000 • 194 citations

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

2007 • 193 citations

Peroxisome proliferator activated receptor in colonic epithelial cells protects against experimental inflammatory bowel disease

2005 • 191 citations

The 5′ Untranslated Region, Signal Peptide, and the Coding Sequence of the Carboxyl Terminus of IL-15 Participate in Its Multifaceted Translational Control

1998 • 189 citations

Critical role of IL-15–IL-15R for antigen-presenting cell functions in the innate immune response

2001 • 179 citations

A Novel Role for Interleukin-18 in Adhesion Molecule Induction through NFκB and Phosphatidylinositol (PI) 3-Kinase-dependent Signal Transduction Pathways

2001 • 167 citations

Autocrine/Paracrine IL-15 That Is Required for Type I IFN-Mediated Dendritic Cell Expression of MHC Class I-Related Chain A and B Is Impaired in Hepatitis C Virus Infection

2003 • 167 citations

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

2003 • 164 citations

Defective Interleukin (IL)-18–mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor–associated Kinase (IRAK)-deficient Mice

1999 • 164 citations

Transregulation of memory CD8 T-cell proliferation by IL-15Rα+ bone marrow–derived cells

2003 • 162 citations

Regulation of IL-18 (IFN-gamma-inducing factor) gene expression.

1997 • 162 citations

Generation of Functional Human Dendritic Cells From Adherent Peripheral Blood Monocytes by CD40 Ligation in the Absence of Granulocyte-Macrophage Colony-Stimulating Factor

1998 • 159 citations

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

2003 • 158 citations

Transcriptional Analysis of Multiple Sclerosis Brain Lesions Reveals a Complex Pattern of Cytokine Expression

2000 • 157 citations

Interleukin 18–independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation

2006 • 156 citations

Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis

1998 • 155 citations

Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial

2009 • 144 citations

IL-18 might reflect disease activity in mild and moderate asthma exacerbation

2001 • 142 citations

Expression and Release of IL-18 Binding Protein in Response to IFN-γ

2001 • 141 citations

Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein

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Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells.

1996 • 139 citations

Interleukin-18 Activates the IRAK-TRAF6 Pathway in Mouse EL-4 Cells

1998 • 138 citations

Interleukin-15 (IL-15) Induces IL-8 and Monocyte Chemotactic Protein 1 Production in Human Monocytes

1997 • 137 citations

Natural, Proteolytic Release of a Soluble Form of Human IL-15 Receptor α-Chain That Behaves as a Specific, High Affinity IL-15 Antagonist

2004 • 132 citations

Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells

2011 • 130 citations

Targeting IL-15 Receptor-Bearing Cells with an Antagonist Mutant IL-15/Fc Protein Prevents Disease Development and Progression in Murine Collagen-Induced Arthritis

2004 • 129 citations

Polymorphisms in the IL 18 gene are associated with specific sensitization to common allergens and allergic rhinitis

2003 • 125 citations

Role of IFN-γ in Th1 Differentiation: IFN-γ Regulates IL-18Rα Expression by Preventing the Negative Effects of IL-4 and by Inducing/Maintaining IL-12 Receptor β2 Expression

2002 • 123 citations

Regulation of lymphoid homeostasis by interleukin-15

2002 • 115 citations

In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive, and undifferentiated arthritis.

1997 • 115 citations

Fibroblast-Like Synoviocytes from Rheumatoid Arthritis Patients Express Functional IL-15 Receptor Complex: Endogenous IL-15 in Autocrine Fashion Enhances Cell Proliferation and Expression of Bcl-xL and Bcl-2

2002 • 112 citations

IL-15 constrains mast cell–dependent antibacterial defenses by suppressing chymase activities

2007 • 112 citations

CD56^bright natural killer cell subsets: Characterization of distinct functional responses to interleukin‐2 and the c‐kit ligand

1997 • 111 citations

Up-Regulation of NK Cytotoxic Activity Via IL-15 Induction by Different Viruses: A Comparative Study

1999 • 111 citations

A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells

2006 • 108 citations

Interleukin 15 activity in the rectal mucosa of inflammatory bowel disease

1998 • 107 citations

Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis

1998 • 100 citations

Increased numbers of interleukin-15-expressing cells in active ulcerative colitis.

1996 • 97 citations

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Rα

2007 • 97 citations

Adenoviral delivery of IL-18 binding protein C ameliorates Collagen-Induced Arthritis in mice

2003 • 95 citations

Interleukin‐18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways

2007 • 95 citations

IL-18 Induces Monocyte Chemotactic Protein-1 Production in Macrophages through the Phosphatidylinositol 3-Kinase/Akt and MEK/ERK1/2 Pathways

2005 • 92 citations

Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity.

2004 • 91 citations

Survival adjustment of mature dendritic cells by IL-15

2005 • 90 citations

Fibroblasts from Human Spleen Regulate NK Cell Differentiation from Blood CD34+ Progenitors Via Cell Surface IL-15

2002 • 87 citations

Mechanisms involved in interleukin‐15‐induced suppression of human neutrophil apoptosis: role of the anti‐apoptotic Mcl‐1 protein and several kinases including Janus kinase‐2, p38 mitogen‐activated protein kinase and extracellular signal‐regulated kinases‐1/2

2002 • 87 citations

Crystal structure of the IL-15–IL-15Rα complex, a cytokine-receptor unit presented in trans

2007 • 87 citations

Treatment of Established Relapsing Experimental Autoimmune Encephalomyelitis with the Proteasome Inhibitor PS-5191

2000 • 85 citations

Systemic Administration of IL-18 Promotes Diabetes Development in Young Nonobese Diabetic Mice

2003 • 84 citations

The IL-15Rα Chain Signals Through Association with Syk in Human B Cells

2001 • 84 citations

The roles of interleukin-15 receptor α: Trans-presentation, receptor component, or both?

2005 • 83 citations

Natural Soluble Interleukin-15Rα Is Generated by Cleavage That Involves the Tumor Necrosis Factor-α-converting Enzyme (TACE/ADAM17)

2004 • 83 citations

Interleukin-18 Induces Rheumatoid Arthritis Synovial Fibroblast CXC Chemokine Production through NFκB Activation

2001 • 82 citations

Interleukin-18 Promotes Joint Inflammation and Induces Interleukin-1-Driven Cartilage Destruction

2004 • 80 citations

Interleukin-15 Prevents Mouse Mast Cell Apoptosis through STAT6-mediated Bcl-xL Expression

2001 • 80 citations

Polymorphisms in Interleukin-15 Gene on Chromosome 4q31.2 Are Associated with Psoriasis Vulgaris in Chinese Population

2007 • 76 citations

Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis

2002 • 75 citations

IL-15 mRNA expression is up-regulated in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis (MS)

1998 • 72 citations

An Absolute Requirement for STAT4 and a Role for IFN-γ as an Amplifying Factor in IL-12 Induction of the Functional IL-18 Receptor Complex

2001 • 72 citations

IL‐15 mediates antigen‐induced neutrophil migration by triggering IL‐18 production

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Up‐regulation of IL‐18 in allergic rhinitis

2002 • 71 citations

Blocking IL-15 Prevents the Induction of Allergen-Specific T Cells and Allergic Inflammation In Vivo

2005 • 71 citations

Dermal Fibroblasts Sustain Proliferation of Activated T Cells via Membrane-Bound Interleukin-15 upon Long-Term Stimulation with Tumor Necrosis Factor-α

2001 • 70 citations

Anti-tumour necrosis factor (TNF) alpha treatment of rheumatoid arthritis (infliximab) selectively down regulates the production of interleukin (IL) 18 but not of IL12 and IL13

2002 • 70 citations

Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Rα chain

2004 • 70 citations

Differential regulation of spontaneous and immune complex‐induced neutrophil apoptosis by proinflammatory cytokines. Role of oxidants, Bax and caspase‐3

2002 • 69 citations

Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention

2004 • 67 citations

Interleukin-15 Induces Rapid Tyrosine Phosphorylation of STAT6 and the Expression of Interleukin-4 in Mouse Mast Cells

2000 • 67 citations

The toll-like receptor-nuclear factor kB pathway in rheumatoid arthritis

2005 • 66 citations

Preclinical and phase I clinical trial of blockade of IL-15 using Mikβ1 monoclonal antibody in T cell large granular lymphocyte leukemia

2005 • 66 citations

IL-1 Receptor-Associated Kinase 4 Is Essential for IL-18-Mediated NK and Th1 Cell Responses

2003 • 65 citations

Expression and alternative processing of IL‐18 inhuman neutrophils

2006 • 60 citations

The role of innate mediators in inflammatory response

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New cytokine targets in inflammatory rheumatic diseases

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Interferon-gamma:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue.

2002 • 53 citations

Effect of nuclear factor-kappaB inhibition on rheumatoid fibroblast-like synoviocytes and collagen induced arthritis.

2005 • 51 citations

Expression and responsiveness of human interleukin-18 receptor (IL-18R) on hematopoietic cell lines

2000 • 51 citations

Signalling, inflammation and arthritis: Crossed signals: the role of interleukin (IL)-12, -17, -23 and -27 in autoimmunity

2008 • 49 citations

The Structure of the Interleukin-15α Receptor and Its Implications for Ligand Binding

2005 • 49 citations

Humanized antibody directed to the IL-2 receptor beta-chain prolongs primate cardiac allograft survival.

1994 • 47 citations

Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells

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New strategies to control inflammatory synovitis: interleukin 15 and beyond

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Lack of association between three vascular endothelial growth factor gene polymorphisms and systemic sclerosis: results from a multicenter EUSTAR study of European Caucasian patients

2006 • 38 citations

CD40–CD40 ligand (CD154) engagement is required but may not be sufficient for human T helper 1 cell induction of interleukin‐2‐ or interleukin‐15‐driven, contact‐dependent, interleukin‐1β production by monocytes

2000 • 36 citations

Role of interleukin 18 in rheumatoid arthritis

2003 • 33 citations

Ontogeny and Expansion of Human Natural Killer Cells: Clinical Implications

2001 • 33 citations

Host's innate immune response to fungal and bacterial agents in vitro: up‐regulation of interleukin‐15 gene expression resulting in enhanced natural killer cell activity

2003 • 31 citations

Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway

2007 • 30 citations

Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS

2008 • 25 citations

Macrophage-Derived IL-18 Targeting for the Treatment of Crohns Disease

2003 • 25 citations

Interleukin‐15 expression by human endothelial cells: up‐regulation by ultraviolet B and psoralen plus ultraviolet A treatment

1996 • 24 citations

Retraction: Endogenous IL-15 Sustains Recruitment of IL-2Rβ and Common γ and IL-2-Mediated Chemokine Production in Normal and Inflamed Human Gingival Fibroblasts

2009 • 16 citations

Endogenous IL-15 Sustains Recruitment of IL-2Rβ and Common γ and IL-2-Mediated Chemokine Production in Normal and Inflamed Human Gingival Fibroblasts

2004 • 15 citations

The IL-2/IL-2 Receptor System. Involvement of a Novel Receptor Subunit, .GAMMA. Chain, in Growth Signal Transduction.

1992 • 13 citations

Deleted Work

1955 • 0 citations