The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

1998 • 940 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

Protein tyrosine phosphatases in signal transduction

1997 • 766 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Evidence for the identity of human scatter factor and human hepatocyte growth factor.

1991 • 651 citations

A family of proteins that inhibit signalling through tyrosine kinase receptors

1997 • 648 citations

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1996 • 572 citations

Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

1991 • 491 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2

1997 • 474 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes.

1989 • 455 citations

A Novel Membrane Glycoprotein, SHPS-1, That Binds the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-2 in Response to Mitogens and Cell Adhesion

1996 • 443 citations

Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.

1989 • 411 citations

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.

1993 • 409 citations

Hepatocyte Growth Factor/Scatter Factor Is an Axonal Chemoattractant and a Neurotrophic Factor for Spinal Motor Neurons

1996 • 403 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling

2000 • 350 citations

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development

1995 • 330 citations

Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly

1998 • 330 citations

A novel putative receptor protein tyrosine kinase of the met family.

1993 • 321 citations

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

1993 • 319 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Cloning of p97/Gab2, the Major SHP2-Binding Protein in Hematopoietic Cells, Reveals a Novel Pathway for Cytokine-Induced Gene Activation

1998 • 313 citations

Structure and function of hepatocyte growth factor

1991 • 307 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2

1998 • 297 citations

E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control

2000 • 292 citations

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

1998 • 287 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

The IRS-signalling system during insulin and cytokine action

1997 • 280 citations

Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains

1995 • 276 citations

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1997 • 276 citations

Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE

1991 • 253 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors

1999 • 241 citations

Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells

1995 • 231 citations

Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity

2000 • 230 citations

Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons

1997 • 223 citations

Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2

1999 • 219 citations

Morphogenetic Mechanisms of Epithelial Tubulogenesis: MDCK Cell Polarity Is Transiently Rearranged without Loss of Cell–Cell Contact during Scatter Factor/Hepatocyte Growth Factor-Induced Tubulogenesis

1998 • 218 citations

Phosphoinositide 3-Kinase Induces Scattering and Tubulogenesis in Epithelial Cells through a Novel Pathway

1998 • 216 citations

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.

1993 • 214 citations

Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling

1996 • 210 citations

Regulation of cell movement: the motogenic cytokines

1991 • 199 citations

The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

1999 • 194 citations

DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila

1996 • 180 citations

Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356

1997 • 165 citations

Evidence for the identy of human scatter factor and human hepatocyte growth factor.

1991 • 163 citations

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

1997 • 155 citations

The Shp-2 Tyrosine Phosphatase Has Opposite Effects in Mediating the Activation of Extracellular Signal-regulated and c-Jun NH2-terminal Mitogen-activated Protein Kinases

1998 • 155 citations

Genetic analysis of protein tyrosine phosphatases

1998 • 145 citations

Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas.

1992 • 141 citations

Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing.

1991 • 139 citations

Gab2, a New Pleckstrin Homology Domain-containing Adapter Protein, Acts to Uncouple Signaling from ERK Kinase to Elk-1

1999 • 135 citations

Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.

1994 • 130 citations

Pathways Downstream of Shc and Grb2 Are Required for Cell Transformation by the Tpr-Met Oncoprotein

1996 • 129 citations

Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1

1997 • 116 citations

Structural Determinants of SHP-2 Function and Specificity in Xenopus Mesoderm Induction

1998 • 115 citations

Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

1999 • 104 citations

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf

1996 • 102 citations

The Gab1 Protein Is a Docking Site for Multiple Proteins Involved in Signaling by the B Cell Antigen Receptor

1998 • 93 citations

Opposing Actions of CSW and RasGAP Modulate the Strength of Torso RTK Signaling in the Drosophila Terminal Pathway

1998 • 92 citations

Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 – Crk signaling complex formation

1999 • 90 citations

SHP-2, SH2-containing protein tyrosine phosphatase-21Due to the limitation of references we would like to apologize to all authors that contributed important results to the elucidation of the biological function of SHP-2 and could not be mentioned in this review.1

1998 • 88 citations

Tumorigenicity of the met Proto-Oncogene and the Gene for Hepatocyte Growth Factor

1992 • 83 citations

A Conserved Inositol Phospholipid Binding Site within the Pleckstrin Homology Domain of the Gab1 Docking Protein Is Required for Epithelial Morphogenesis

1999 • 81 citations

Branching Tubulogenesis but Not Scatter of Madin-Darby Canine Kidney Cells Requires a Functional Grb2 Binding Site in the Met Receptor Tyrosine Kinase

1996 • 77 citations

Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584.

1996 • 71 citations

Receptor chimeras indicate that the met tyrosine kinase mediates the motility and morphogenic responses of hepatocyte growth/scatter factor.

1994 • 64 citations

The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor.

1993 • 61 citations

Identification of Tyrosine Phosphorylation Sites in Human Gab-1 Protein by EGF Receptor Kinase in Vitro

1998 • 51 citations

Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the Sevenless receptor tyrosine kinase

1999 • 49 citations

Characterization of hepatocyte‐growth‐factor receptors on Meth A cells

1992 • 44 citations

Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor

1998 • 38 citations

Alternative Splicing Generates Isoforms of the met Receptor Tyrosine Kinase Which Undergo Differential Processing

1991 • 32 citations

Expression of the met/Hepatocyte Growth Factor/Scatter Factor Receptor and Its Ligand during Differentiation of Murine P19 Embryonal Carcinoma Cells

1993 • 29 citations

Mutational Analysis of the SRC Homology 2 Domain Protein-tyrosine Phosphatase Corkscrew

1998 • 25 citations

The Tyrosines in the Bidentate Motif of the env-sea Oncoprotein Are Essential for Cell Transformation and Are Binding Sites for Grb2 and the Tyrosine Phosphatase SHP-2

1999 • 23 citations